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α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrP ^C -CCR5 dependent pathway.

Autor: Oliveira da Silva MI; Neurodegeneration Team, Nerve Regeneration Group, IBMC -Instituto de Biologia Molecular e Celular and i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135, Porto, Portugal., Santejo M; Neurodegeneration Team, Nerve Regeneration Group, IBMC -Instituto de Biologia Molecular e Celular and i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135, Porto, Portugal., Babcock IW; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA., Magalhães A; Addiction Biology Group, IBMC -Instituto de Biologia Molecular e Celular and i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135, Porto, Portugal., Minamide LS; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA., Won SJ; Department of Neurology, University of California, San Francisco, CA, 94158, USA., Castillo E; Department of Neurology, University of California, San Francisco, CA, 94158, USA., Gerhardt E; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073, Göttingen, Germany., Fahlbusch C; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073, Göttingen, Germany., Swanson RA; Department of Neurology, University of California, San Francisco, CA, 94158, USA., Outeiro TF; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073, Göttingen, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077, Göttingen, Germany.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.; Scientific employee with an honorary contract at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), 37075, Göttingen, Germany., Taipa R; Neuropathology Unit, Centro Hospitalar Universitário de Santo António, 4099-001, Porto, Portugal.; Autoimmune and Neuroscience Research Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, 4050-313, Porto, Portugal.; ITR - Laboratory for Integrative and Translational Research in Population Health, 4050-600, Porto, Portugal., Ruff M; Creative Bio-Peptides, Rockville, MD, 20854, USA., Bamburg JR; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA., Liz MA; Neurodegeneration Team, Nerve Regeneration Group, IBMC -Instituto de Biologia Molecular e Celular and i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135, Porto, Portugal. maliz@ibmc.up.pt.

Publikováno v: Cell death & disease [Cell Death Dis] 2024 Apr 13; Vol. 15 (4), pp. 264. Date of Electronic Publication: 2024 Apr 13.