Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.

Autor: Li M; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Oliveira Passos D; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Shan Z; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Smith SJ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Sun Q; Center for Biophysics and Computational Biology, and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA., Biswas A; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Choudhuri I; Center for Biophysics and Computational Biology, and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA., Strutzenberg TS; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Haldane A; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Deng N; Department of Chemistry and Physical Sciences, Pace University, New York, NY, 10038, USA., Li Z; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Zhao XZ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Briganti L; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Kvaratskhelia M; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Burke TR Jr; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Levy RM; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Hughes SH; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Craigie R; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Lyumkis D; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA.

Publikováno v: Science advances [Sci Adv] 2023 Jul 21; Vol. 9 (29), pp. eadg5953. Date of Electronic Publication: 2023 Jul 21.