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pro vyhledávání: '"Oliveira, Ana Cristina Norberto Gonçalves"'
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Tese de Doutoramento em Biologia Molecular e Ambiental - Especialidade em Biologia Celular e Saúde
A possibilidade de utilizar o mecanismo de RNA de interferência (RNAi) em terapias genéticas constitui um dos grandes avanços científicos do
A possibilidade de utilizar o mecanismo de RNA de interferência (RNAi) em terapias genéticas constitui um dos grandes avanços científicos do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::db562697d98419a395356dae00fa68b7
Autor:
Silva, João P. N., Oliveira, Ana Cristina Norberto Gonçalves, Gomes, A. C., Oliveira, M. Elisabete
The artificial introduction of nucleic acids (NA) into mammalian cells (transfection) has become, in recent years, a well-established procedure in basic and applied research, which allowed the study of gene function and regulation. The advances in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______307::0d6d12be7860c655ea4bcdf0e9f29467
https://hdl.handle.net/1822/20399
https://hdl.handle.net/1822/20399
Autor:
Oliveira, Ana Cristina Norberto Gonçalves, Silva, J. P. Neves, Coutinho, Paulo J. G., Gomes, A. A., Coutinho, O. P., Oliveira, M. Elisabete
Cationic liposomes/DNA (lipoplexes) have been widely used as non-viral vectors for transfection, the role of the neutral lipid in liposome formulation being determinant for the efficiency of this process [1,2]. In this work, we studied the potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______307::96823db2a0c5f2ad8fd7d1adc34457a8
https://hdl.handle.net/1822/14165
https://hdl.handle.net/1822/14165
Autor:
Oliveira, Ana Cristina Norberto Gonçalves, Silva, J. P. Neves, Coutinho, Paulo J. G., Gomes, A. C., Coutinho, O. P., Oliveira, M. Elisabete
The success of gene therapy is decisively dependent on the development of effective carrier systems, able to compact and thus protect the genetic material as to avoid both in vitro and in vivo barriers for transgene delivery [1]. Given the problems o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______307::73ead68ac46e33e258a15425a48c7361
https://hdl.handle.net/1822/14119
https://hdl.handle.net/1822/14119
Autor:
Oliveira, Ana Cristina Norberto Gonçalves, Silva, J. P. Neves, Oliveira, I. M. S. C., Coutinho, O. P., Gomes, A. C., Oliveira, M. Elisabete
Cationic liposomes/ DNA complexes (lipoplexes) have been widely used as nano-carriers for animal cell transfection, with the neutral lipid (helper) playing a determinant role for the efficiency of this process due to the formation of non-lammellar in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______307::040bca16daa08cacbf42d131179c1339
https://hdl.handle.net/1822/14142
https://hdl.handle.net/1822/14142
Autor:
Oliveira, Ana Cristina Norberto Gonçalves, Silva, J. P. Neves, Coutinho, Paulo J. G., Gomes, A. A., Coutinho, O. P., Oliveira, M. Elisabete
Lipoplexes composed of pDNA and DODAB/MO at different molar ratios (4:1, 2:1 and 1:1) and different cationic lipid/DNA charge ratios were investigated. The physicochemical properties of the lipoplexes (size and charge), the pDNA complexation, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______307::7e8d5026d7f3f8aa316767862e953e88
https://hdl.handle.net/1822/14095
https://hdl.handle.net/1822/14095