Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Olivares-Morales A"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 333-345 (2023)
Abstract Whole‐body physiologically‐based pharmacokinetic (PBPK) models have many applications in drug research and development. It is often necessary to inform these models with animal or clinical data, updating model parameters, and making the
Externí odkaz:
https://doaj.org/article/d9d316f569544d5aa0ea4140131d453d
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 346-359 (2023)
Abstract Simplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to in vivo pharmacokinetic (PK) data. After optimization w
Externí odkaz:
https://doaj.org/article/ae947b9e7b6946dda689634831c73464
Publikováno v:
Logos: Revista de Lingüística, Literatura y Filosofía, Vol 33, Iss 1 (2023)
Diversas evidencias parecen indicar que, durante la comprensión oral, el procesamiento del habla se realiza a partir de la información verbal auditiva y de la información viso-gestual proveniente del interlocutor. En este marco, se evaluó el tiem
Externí odkaz:
https://doaj.org/article/f8892c1a01ee432e80f2167ff11b52fb
Autor:
Yau, Estelle1,2,3 (AUTHOR), Olivares‐Morales, Andrés2 (AUTHOR), Ogungbenro, Kayode1 (AUTHOR), Aarons, Leon1 (AUTHOR), Gertz, Michael2 (AUTHOR) michael.gertz@roche.com
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. Mar2023, Vol. 12 Issue 3, p333-345. 13p.
Autor:
Bianca D. vanGroen, Venkatesh Pilla Reddy, Justine Badée, Andrés Olivares‐Morales, Trevor N. Johnson, Johan Nicolaï, Pieter Annaert, Anne Smits, Saskia N. deWildt, Catherijne A. J. Knibbe, Loeckie deZwart
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 29-35 (2021)
On April 24, 2019, a symposium on Pediatric Pharmacokinetics and Dose Predictions was held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought together scientists from academia, industry, and clinical research organ
Externí odkaz:
https://doaj.org/article/690f10a798a64e0ea88774b713cf9363
Autor:
Smith, Dennis A., van Waterschoot, Robert A.B., Parrott, Neil J., Olivares-Morales, Andrés, Lavé, Thierry, Rowland, Malcolm
Publikováno v:
In Drug Discovery Today December 2018 23(12):2023-2030
Akademický článek
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Autor:
Giuseppe Cecere, Laura Guasch, Andres M. Olivares-Morales, Kenichi Umehara, Antonia F. Stepan
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1444-1451
The in vivo half-life is a key property of every drug molecule, as it determines dosing regimens, peak-to-trough ratios and often dose. However, half-life optimization can be challenging due to its multifactorial nature, with in vitro metabolic turno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4fab8f3f3d23cfdea42c80d387e609
https://doi.org/10.1021/acsmedchemlett.2c00183
https://doi.org/10.1021/acsmedchemlett.2c00183
Autor:
Karen Dubois-Camacho, David Diaz-Jimenez, Marjorie De la Fuente, Rodrigo Quera, Daniela Simian, Maripaz Martínez, Glauben Landskron, Mauricio Olivares-Morales, John A. Cidlowski, Xiaojiang Xu, Guangping Gao, Jun Xie, Jonás Chnaiderman, Ricardo Soto-Rifo, María-Julieta González, Andrea Calixto, Marcela A. Hermoso
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators such as IL-33, which is shown t
Externí odkaz:
https://doaj.org/article/f6eaa6ce2143417398da4481330bc295
Autor:
Alejandra Alvestegui, Mauricio Olivares-Morales, Ernesto Muñoz, Rachel Smith, James P. Nataro, Fernando Ruiz-Perez, Mauricio J. Farfan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Enteroaggregative Escherichia coli (EAEC) infections are one of the most frequent causes of persistent diarrhea in children, immunocompromised patients and travelers worldwide. The most prominent colonization factors of EAEC are aggregative adherence
Externí odkaz:
https://doaj.org/article/6979e1622f76425d9b430d4c7b76db67