Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Olivacine"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Beata Tylińska, Benita Wiatrak
Publikováno v:
Biology, Vol 10, Iss 6, p 564 (2021)
Olivacine and its derivatives are characterized by multidirectional biological activity. Noteworthy is their antiproliferative effect related to various mechanisms, such as inhibition of growth factors, enzymes, kinases and others. The activity of th
Externí odkaz:
https://doaj.org/article/7f4ed05834af4fe787ca1b92615f6eac
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Molecules, Vol 25, Iss 11, p 2512 (2020)
Olivacine is an alkaloid-containing pyridocarbazole structure. It is isolated from the bark of the evergreen timber tree, Aspidosperma olivaceum. Its well-documented anticancer activity led to the synthesis of new derivatives, which are semisynthetic
Externí odkaz:
https://doaj.org/article/c5bf23961b0d4b85945766544c8c1be9
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jan Spychala, Agnieszka Dobosz, Żaneta Czyżnikowska, Amadeusz Kuźniarski, Łucja Cwynar-Zając, Beata Tylińska, Tomasz Gębarowski
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8492, p 8492 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8492, p 8492 (2021)
Volume 22
Issue 16
Olivacine and ellipticine are model anticancer drugs acting as topoisomerase II inhibitors. Here, we present investigations performed on four olivacine derivatives in light of their antitumor activity. The aim of this study was to identify the best a
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6119
Ellipticine is an indole alkaloid with proven antitumor activity against various tumors in vitro and a diverse mechanism of action, which includes topoisomerase II inhibition, intercalation, and cell cycle impact. Olivacine—ellipticine’s isomer
Autor:
Ulrike Schmidt, Gabriele Theumer, Anne Jäger, Olga Kataeva, Baojie Wan, Scott G. Franzblau, Hans-Joachim Knölker
Publikováno v:
Molecules, Vol 23, Iss 6, p 1402 (2018)
The tetracyclic pyrido[4,3-b]carbazole olivacine and four of its oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as a key step. In a test for the inhibition of the growth of M
Externí odkaz:
https://doaj.org/article/42d4ce2a6bfc4c5ba14ab5dcb21bb387
Publikováno v:
Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2512, p 2512 (2020)
Volume 25
Issue 11
Molecules, Vol 25, Iss 2512, p 2512 (2020)
Olivacine is an alkaloid-containing pyridocarbazole structure. It is isolated from the bark of the evergreen timber tree, Aspidosperma olivaceum. Its well-documented anticancer activity led to the synthesis of new derivatives, which are semisynthetic
Publikováno v:
The Journal of Organic Chemistry. 84:7901-7916
Effective preparation of olivacine and ellipticine via late-stage D-ring cyclization is described. Key features of the synthetic routes include trifluoroacetic acid-mediated formation of a lactone that is fused to a tetrahydrocarbazole derivative and