Clinical characterization of data-driven diabetes subgroups in Mexicans using a reproducible machine learning approach

Autor: Omar Yaxmehen Bello-Chavolla, Jessica Paola Bahena-López, Arsenio Vargas-Vázquez, Neftali Eduardo Antonio-Villa, Alejandro Márquez-Salinas, Carlos A Fermín-Martínez, Rosalba Rojas, Roopa Mehta, Ivette Cruz-Bautista, Ana Cristina García-Ulloa, Paloma Almeda-Valdes, Carlos Alberto Aguilar-Salinas, Olimpia Arellano-Campos, Donaji V Gómez-Velasco, César Lam-Chung, Marco A Melgarejo-Hernandez, Alexandro J Martagón, Liliana Muñoz-Hernandez, Luz E Guillén, José de Jesús Garduño-García, Ulices Alvirde, Yukiko Ono-Yoshikawa, Ricardo Choza-Romero, Leobardo Sauque-Reyna, Ma Eugenia Garay-Sevilla, Juan M Malacara-Hernandez, María Teresa Tusié-Luna, Luis Miguel Gutierrez-Robledo, Francisco J Gómez-Pérez, Cristina García-Ulloa, Eder Patiño-Rivera, Denise Arcila-Martínez, Rodrigo Arizmendi-Rodríguez, Oswaldo Briseño-González, Humberto Del Valle-Ramírez, Arturo Flores-García, Fernanda Garnica-Carrillo, Eduardo González-Flores, Mariana Granados-Arcos, Héctor Infanzón-Talango, Victoria Landa-Anell, Claudia Lechuga-Fonseca, Arely López-Reyes, Marco Melgarejo-Hernández, Palacios-Vargas Angélica, Liliana Pérez-Peralta, Alberto Ramírez-García, David Rivera de la Parra, Sofía Ríos-Villavicencio, Francis Rojas-Torres, Marcela Ruiz-Cervantes, Sandra Sainos-Muñoz, Alejandra Sierra-Esquivel, Erendi Tinoco-Ventura, Luz Elena Urbina-Arronte, María Luisa Velasco-Pérez, Héctor Velázquez-Jurado, Andrea Villegas-Narváez, Verónica Zurita-Cortés, Enrique Graue-Hernández Aída Jiménez-Corona, Carlos A. Aguilar-Salinas

Publikováno v: BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)

Introduction Previous reports in European populations demonstrated the existence of five data-driven adult-onset diabetes subgroups. Here, we use self-normalizing neural networks (SNNN) to improve reproducibility of these data-driven diabetes subgrou

Externí odkaz: https://doaj.org/article/79a5bbd340834536a8dde9b9ecf1f5c1

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

Autor: Carlos A. Aguilar-Salinas, Juan M. Malacara-Hernández, Omar Yaxmehen Bello-Chavolla, Ivette Cruz-Bautista, Leobardo Sauque-Reyna, Ricardo Choza-Romero, Marco Antonio Melgarejo-Hernández, Yukiko Ono-Yoshikawa, Ma. Eugenia Garay-Sevilla, Olimpia Arellano-Campos, Francisco J. Gómez-Pérez, José de Jesús Garduño-García, Rosalba Rojas, Roopa Mehta, Ulices Alvirde, María Teresa Tusié-Luna, Liliana Muñoz-Hernandez, Neftali Eduardo Antonio-Villa, Luz E. Guillén, Donaji V. Gómez-Velasco, Luis Miguel Gutiérrez-Robledo, Arsenio Vargas-Vázquez, Alexandro J. Martagón, Paloma Almeda-Valdes

Publikováno v: J Clin Hypertens (Greenwich)

Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non–insulin‐based IR indexes were developed as tools for metabolic screening. Here, we aimed to evaluate the novel non–insulin‐based Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019dfa40756c2ca5e2eeb2ae9f396f0a
https://doi.org/10.1111/jch.13614

Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas

Autor: Ivette Cruz-Bautista, Rosario Rodríguez-Guillén, Omar Yaxmehen Bello-Chavolla, María Teresa Tusié-Luna, Tannia Viveros-Ruiz, María Luisa Ordóñez-Sánchez, Carlos A. Aguilar-Salinas, Liliana Muñoz-Hernandez, Magdalena del Rocío Sevilla-González, Roopa Mehta, Jose C. Florez, Olimpia Arellano-Campos, Geoffrey A. Walford, Alexandro J. Martagón, Donaji V. Gómez-Velasco, Paloma Almeda-Valdes

Publikováno v: Diabetes Care. 41:1726-1731

OBJECTIVE To assess whether an ethnic-specific variant (p.E508K) in the maturity-onset diabetes of the young (MODY) gene hepatocyte nuclear factor-1α (HNF1A) found in Mexicans is associated with higher sensitivity to sulfonylureas, as documented in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a19cb9f0617c649a171e640ecaaf318d
https://doi.org/10.2337/dc18-0384

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes

Autor: Christopher Hartl, Katherine Tooley, Laura Riba, David Torrents, Ulises Alvirde, Olimpia Arellano-Campos, Ralph A. DeFronzo, Taru Tukiainen, Geoffrey A. Walford, Noël P. Burtt, Donna M. Lehman, Amy L. Williams, Alicia Huerta-Chagoya, Pierre Fontanillas, Richa Saxena, Stacey Gabriel, Michael Boehnke, Carlos A. Aguilar-Salinas, Stephan Ripke, Yayoi Segura-Kato, Steven A. McCarroll, Jacqueline M. Lane, Brian E. Henderson, Ravindranath Duggirala, Sobha Puppala, Ignasi Moran, Humberto García-Ortiz, Lizz Caulkins, María Elena González-Villalpando, Vineeta Agarwala, Maria L. Cortes, Jorge Ferrer, Cristina Revilla-Monsalve, Graeme I. Bell, Jason Flannick, Francisco Barajas-Olmos, María Luisa Ordóñez-Sánchez, Angélica Martínez-Hernández, Robert L. Hanson, Jose C. Florez, Broad Genomics Platform, Clicerio González-Villalpando, Ivette Cruz-Bautista, Rosario Rodríguez-Guillén, Sílvia Bonàs-Guarch, Rachel G. Liao, Lorena Orozco, Kathleen A. Jablonski, Daniel G. MacArthur, Elvia Mendoza-Caamal, Emilio J. Cordova, Karol Estrada, Hortensia Moreno-Macías, Leslie J. Baier, Avery Davis Bell, Hanna E. Abboud, Suzanne B.R. Jacobs, Maribel Rodriguez-Torres, Xavier Soberón, William C. Knowler, David Altshuler, Zachary Dymek, Christopher A. Haiman, Josep M. Mercader, Donaji V. Gómez-Velasco, Liliana Muñoz-Hernandez, Joanne E. Curran, Loic Le Marchand, Maegan Harden, Lynne R. Wilkens, John Blangero, Teresa Tusié-Luna, Federico Centeno-Cruz, Ling Chen, Craig L. Hanis, Carlos Zerrweck, Sergio Islas-Andrade, Cecilia Contreras-Cubas, Christopher P. Jenkinson

Publikováno v: Diabetes. 66:2903-2914

Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d58bd10df5e8a8fa75529f2b8410f28
https://doi.org/10.2337/db17-0187

Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene

Autor: Marcus Alvarez, Zong Miao, María Luisa Ordóñez-Sánchez, Karen L. Mohlke, Ivette Cruz-Bautista, Carlos A. Aguilar-Salinas, Yash V. Bhagat, Päivi Pajukanta, Arthur Ko, Luis Gonzalez, Linda L. Muñoz-Hernández, Alejandra Rodriguez, Rosario Rodríguez-Guillén, Olimpia Arellano-Campos, Teresa Tusie-Luna, Markku Laakso, Elina Nikkola

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 36:1350-1355

Objective— We recently identified a locus on chromosome 18q11.2 for high serum triglycerides in Mexicans. We hypothesize that the lead genome-wide association study single-nucleotide polymorphism rs9949617, or its linkage disequilibrium proxies, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491e9c144e0aca578d80246bd5514539
https://doi.org/10.1161/atvbaha.116.307182