An intranasal ASO therapeutic targeting SARS-CoV-2

Autor: Chi Zhu, Justin Y. Lee, Jia Z. Woo, Lei Xu, Xammy Nguyenla, Livia H. Yamashiro, Fei Ji, Scott B. Biering, Erik Van Dis, Federico Gonzalez, Douglas Fox, Eddie Wehri, Arjun Rustagi, Benjamin A. Pinsky, Julia Schaletzky, Catherine A. Blish, Charles Chiu, Eva Harris, Ruslan I. Sadreyev, Sarah Stanley, Sakari Kauppinen, Silvi Rouskin, Anders M. Näär

Publikováno v: Zhu, C, Lee, J Y, Woo, J Z, Xu, L, Nguyenla, X, Yamashiro, L H, Ji, F, Biering, S B, Van Dis, E, Gonzalez, F, Fox, D, Wehri, E, Rustagi, A, Pinsky, B A, Schaletzky, J, Blish, C A, Chiu, C, Harris, E, Sadreyev, R I, Stanley, S, Kauppinen, S, Rouskin, S & Näär, A M 2022, ' An intranasal ASO therapeutic targeting SARS-CoV-2 ', Nature Communications, vol. 13, no. 1, 4503, pp. 4503 . https://doi.org/10.1038/s41467-022-32216-0
Nature communications, vol 13, iss 1

The COVID-19 pandemic is exacting an increasing toll worldwide, with new SARS-CoV-2 variants emerging that exhibit higher infectivity rates and that may partially evade vaccine and antibody immunity. Rapid deployment of non-invasive therapeutic avenu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8495c3da1c1ab0aebd4d13d5e80d0bc8
https://vbn.aau.dk/ws/files/483532516/Zhu_et_al._2022_._An_intranasal_ASO_therapeutic_targeting_SARS_CoV_2.pdf

The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping

Autor: Debiao Zhao, Stephen Pathirana, Mary Bownes

Publikováno v: Pathirana, S, Zhao, D & Bownes, M 2001, ' The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping ', Mechanisms of Development, vol. 109, no. 2, pp. 137-50 . https://doi.org/10.1016/S0925-4773(01)00557-3

The loco gene encodes members of a family of RGS proteins responsible for the negative regulation of G-protein signalling. At least two transcripts of loco are expressed in oogenesis, loco-c2 is observed in the anterior-dorsal follicle cells and is d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e427aa120e138c5c9f9e80280ba5d85
https://doi.org/10.1016/s0925-4773(01)00557-3

A male with unilateral microphthalmia reveals a role for TMX3 in eye development

Autor: Daniel F. Schorderet, Nicolas Chassaing, Tanya Bardakjian, Lars Ellgaard, Jan Riemer, Jarema Malicki, Yan Zhang, Douglas B. Gould, Pui-Yan Kwok, Adele Schneider, David R. FitzPatrick, Matthew Akana, Linda M Nevin, Xiaoyang Bai, Pooja Agarwal, Nelson JimenezLopez, Allen Delaney, Herwig Baier, Ryan Chao, Anne Slavotinek

Publikováno v: Plos One, vol. 5, no. 5, pp. e10565
PloS one, vol 5, iss 5
Chao, R, Nevin, L, Agarwal, P, Riemer, J, Bai, X, Delaney, A, Akana, M, JimenezLopez, N, Bardakjian, T, Schneider, A, Chassaing, N, Schorderet, D F, FitzPatrick, D, Kwok, P, Ellgaard, L, Gould, D B, Zhang, Y, Malicki, J, Baier, H & Slavotinek, A 2010, ' A male with unilateral microphthalmia reveals a role for TMX3 in eye development ', PLoS ONE, vol. 5, no. 5, pp. e10565 . https://doi.org/10.1371/journal.pone.0010565
PLoS ONE, Vol 5, Iss 5, p e10565 (2010)
PLoS ONE

Udgivelsesdato: May 2010 Anophthalmia and microphthalmia are important birth defects, but their pathogenesis remains incompletely understood. We studied a patient with severe unilateral microphthalmia who had a 2.7 Mb deletion at chromosome 18q22.1 t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c399ff78fa67543942712947e03f3c7
https://serval.unil.ch/notice/serval:BIB_41E9F009D72C

Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion

Autor: Kondraganti, S., Mohanam, S., Chintala, S. K., Kin, Y., Jasti, S. L., Nirmala, C., Lakka, S. S., Adachi, Y., Kyritsis, A. P., Ali-Osman, F., Sawaya, R., Gregory Fuller, Rao, J. S.

Publikováno v: Scopus-Elsevier

Increased expression of matrix metalloproteinases (MMPs) has been associated with human glioblastoma tumor progression. In this study, we sought to down-regulate MMP-9 expression by stably transfecting a high-grade glioblastoma cell line with a plasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e78f2952e308c71b2439f6b5791925c7
http://olympias.lib.uoi.gr/jspui/handle/123456789/18411

In vitro and in vivo reversal of multidrug resistance in a human leukemia-resistant cell line by mdr1 antisense oligodeoxynucleotides

Autor: Cucco, C, Calabretta, Bruno

Publikováno v: Cancer research. 56(19)

A major obstacle to successful cancer chemotherapy is the development of multidrug resistance (MDR) by tumor cells. Overexpression of the mdrl gene product P-glycoprotein (P-170) is characteristic of such cells. In this study, in vitro and in vivo re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::85e2bde8d7e11cbd2dd590fa8c652191
https://pubmed.ncbi.nlm.nih.gov/8813118