Zobrazeno 1 - 10
of 11 255
pro vyhledávání: '"Oligodendrocytes"'
Autor:
Smita Jain, Neha Chauhan
Publikováno v:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 60, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is characterized by neurological impairments such as visual and sensory difficulties, motor dysfunction, sphincter issues, incoordination, gait abnormalities, and cognitiv
Externí odkaz:
https://doaj.org/article/2b76313995264b14a5d0774b23aacc51
Autor:
Akihiro Ishii, Joseph A. Pathoulas, Omar MoustafaFathy Omar, Yingying Ge, Annie Y. Yao, Tressa Pantalena, Neeraj Singh, John Zhou, Wanxia He, Patrick Murphy, Riqiang Yan, Xiangyou Hu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer’s disease (AD). BACE1 is the sole β-secretase for Aβ generation, making it an attractive therapeutic target for
Externí odkaz:
https://doaj.org/article/25be563e86234df7b0980f3ab6e5c547
Autor:
Nour-elhouda Neili, Zaineb AbdelKafi-Koubaa, Jed Jebali, Khouloud Kaidi, Ghada Sahraoui, Melika Ben Ahmed, Najet Srairi-Abid, Naziha Marrakchi, Raoudha Doghri, Ines ELBini
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Several neurodegenerative diseases, such as multiple sclerosis and Parkinson’s disease, are linked to alterations in myelin content or structure. Transmembrane receptors such as integrins could be involved in these alterations. In the pres
Externí odkaz:
https://doaj.org/article/e33fe32871b24e25b2cae58504b7b33c
Publikováno v:
Journal of Molecular Pathology, Vol 5, Iss 3, Pp 360-384 (2024)
Background: Alcohol-related brain degeneration (ARBD) is associated with cognitive–motor impairments that can progress to disability and dementia. White matter (WM) is prominently targeted in ARBD due to chronic neurotoxic and degenerative effects
Externí odkaz:
https://doaj.org/article/6f5e3a1627bd45458853ae63042aae94
Publikováno v:
Journal of Physiological Investigation, Vol 67, Iss 4, Pp 161-173 (2024)
Multiple sclerosis (MS) is a complicated, inflammatory disease that causes demyelination of the central nervous system (CNS), resulting in a variety of neurological abnormalities. Over the past several decades, different animal models have been used
Externí odkaz:
https://doaj.org/article/b9e6f17517a6496aa4c91b1ae3beb18a
Autor:
K. Ahuja, M. Vandenabeele, F. Nami, E. Lefevere, J. Van hoecke, S. Bergmans, M. Claes, T. Vervliet, K. Neyrinck, T. Burg, D. De Herdt, P. Bhaskar, Y. Zhu, Z. J. Looser, J. Loncke, W. Gsell, M. Plaas, P. Agostinis, J. V. Swinnen, L. Van Den Bosch, G. Bultynck, A. S. Saab, E. Wolfs, Y. C. Chai, U. Himmelreich, C. Verfaillie, L. Moons, L. De Groef
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-23 (2024)
Abstract Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene. Wh
Externí odkaz:
https://doaj.org/article/1fc5ac8a195045e784ceddeab1da8565
Autor:
Mohammad Dehestani, Velina Kozareva, Cornelis Blauwendraat, Ernest Fraenkel, Thomas Gasser, Vikas Bansal
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson’s disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from a small cohort of
Externí odkaz:
https://doaj.org/article/eed45c239e5848d1b734879955c3654e
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract White matter injury (WMI) is thought to be a major contributor to long-term cognitive dysfunctions after traumatic brain injury (TBI). This damage occurs partly due to apoptotic death of oligodendrocyte lineage cells (OLCs) after the injury,
Externí odkaz:
https://doaj.org/article/fd97104196ae4637a5e14fa0707cd6ba
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive disabilities of sensory, motor and autonomic functions. To date, limitations in current clinical treatm
Externí odkaz:
https://doaj.org/article/33a2f8a8f30f443d9f9349b4637d3c59
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract The incidence of brain diseases in humans is increasing as we experience a worldwide ageing of the population. Treatment for such diseases is still only symptomatic as there are almost no disease-modifying therapies available. Further, since
Externí odkaz:
https://doaj.org/article/4b757ca5c9234aa597b8a63771db4178