Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Oligo delivery"'
Autor:
Bárbara B. Mendes, João Conniot, Aviram Avital, Dongbao Yao, Xingya Jiang, Xiang Zhou, Noga Sharf-Pauker, Yuling Xiao, Omer Adir, Haojun Liang, Jinjun Shi, Avi Schroeder, João Conde
Publikováno v:
Nat Rev Methods Primers
Funding: This work was supported by the European Research Council (ERC) Starting Grant (ERC-StG-2019-848325 to J. Conde) and the Fundação para a Ciência e a Tecnologia FCT Grant (PTDC/BTM-MAT/4738/2020 to J. Conde). J.S. acknowledges US National I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091ebc99ab3f8b966e111ee607e70d41
https://doi.org/10.1038/s43586-022-00104-y
https://doi.org/10.1038/s43586-022-00104-y
Autor:
Estelle De Roeck, Vincianne Jenart, Thuy Hang Nguyen, Anne-Emilie Decleves, Alexandra Belayew, Aline Derenne, Eugénie Ansseau, Alexandre Legrand, Alexandra Tassin, Frédérique Coppée
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Intramuscular injection and electroporation of naked plasmid DNA (IMEP) has emerged as a potential alternative to viral vector injection for transgene expression into skeletal muscles. In this study, IMEP was used to express the DUX4 gene into mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a022f6fa7aa9b25554a1d71f389764
https://doaj.org/article/de019a5459f549d595a0412b6acbd90b
https://doaj.org/article/de019a5459f549d595a0412b6acbd90b
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Small interfering RNAs (siRNAs) are a new class of promising therapeutic molecules that can be used for sequence-specific downregulation of disease-causing genes. However, endosomal entrapment of siRNA is a key hurdle for most delivery strategies, li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28089863ee63f6370a594d94ad2a2325
http://link.springer.com/article/10.1038/s41467-020-15300-1
http://link.springer.com/article/10.1038/s41467-020-15300-1
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Aberrant expression of miRNAs in pancreatic islets is closely related to the development of type 1 diabetes (T1D). The aim of this study was to identify key miRNAs dysregulated in pancreatic islets during T1D progression and to develop a theranostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b521b9ce724535863e857b83cd52e2b8
http://link.springer.com/article/10.1038/s41598-020-62269-4
http://link.springer.com/article/10.1038/s41598-020-62269-4
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, 2020, 5 (1), ⟨10.1038/s41392-020-0207-x⟩
Signal Transduction and Targeted Therapy, Nature.com, 2020
Signal Transduction and Targeted Therapy, Nature.com, 2020, 5 (1), ⟨10.1038/s41392-020-0207-x⟩
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-25 (2020)
Signal Transduction and Targeted Therapy, 2020, 5 (1), ⟨10.1038/s41392-020-0207-x⟩
Signal Transduction and Targeted Therapy, Nature.com, 2020
Signal Transduction and Targeted Therapy, Nature.com, 2020, 5 (1), ⟨10.1038/s41392-020-0207-x⟩
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-25 (2020)
RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequence-specific manner, making small interfering RNA (siRNA) a promising therapeutic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28a224460586d9661314abd4bdd7d59
https://hal.science/hal-02992725/document
https://hal.science/hal-02992725/document
Autor:
Ema Robinson, Yan Xia, Tatiana Ketova, Cosmin Mihai, Joseph P. Griffith, Siddharth Patel, Gaurav Sahay, Adam A. Esposito, Orn Almarsson, Kevin Welsher, John L. Joyal, Shangguo Hou, N. Ashwanikumar
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that incorporation of C-24 alkyl phytosterols into LNPs (eLNPs) enhances gene t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd58ad0cc064b77a50178147a7e3426c
http://europepmc.org/articles/PMC7033178
http://europepmc.org/articles/PMC7033178
Autor:
Gilmar F. Salgado, Josué Carvalho, Jean-Louis Mergny, João A. Queiroz, Maria Paula Cabral Campello, Carla Cruz, António Paulo, Artur Paiva
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
AS1411 is a G-rich DNA oligonucleotide that functions as an aptamer of the protein nucleolin, found at high levels on the surface of cancer cells but not on the surface of normal cells. Herein, we have studied AS1411 as a supramolecular carrier for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff607bb8081ebfa768ae5ea9ea16f434
http://europepmc.org/articles/PMC6538641
http://europepmc.org/articles/PMC6538641
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Autor:
Kazuko Toh, Hiroaki Kinoh, Hiroyasu Takemoto, Mitsunobu R. Kano, Hiroshi Fukuhara, Sumiyo Watanabe, Keisuke Katsushima, Nobuhiro Nishiyama, Kotaro Hayashi, Yutaka Kondo, Hiroyuki Chaya, Satoshi Uchida, Satomi Ogura, Kanjiro Miyata, Takahiro Nomoto, Hyun Jin Kim, Horacio Cabral, Masaomi Nangaku, Kazunori Kataoka, Shigeto Fukushima, Shunya Uchida, Kensuke Osada, Xueying Liu, Yu Matsumoto, Hiroyoshi Y. Tanaka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one of the most critical issues for oligonucleotide therapeutics. Many previous studies encapsulated oligonucleotides into ~100-nm nanoparticles. However, such nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e681b4e8b335d42bea454a42055b10a
https://repo.qst.go.jp/records/77026
https://repo.qst.go.jp/records/77026