Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.

Autor: Wittlinger F; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany., Ogboo BC; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Shevchenko E; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies' Eberhard Karls Universität Tübingen, 72076, Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076, Tübingen, Germany., Damghani T; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Pham CD; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Schaeffner IK; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Oligny BT; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Chitnis SP; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Beyett TS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Rd, Atlanta, GA, 30322, USA., Rasch A; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany., Buckley B; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., Urul DA; AssayQuant Technologies, Inc., Marlboro, MA, 01752, USA., Shaurova T; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., May EW; AssayQuant Technologies, Inc., Marlboro, MA, 01752, USA., Schaefer EM; AssayQuant Technologies, Inc., Marlboro, MA, 01752, USA., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Hershberger PA; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., Poso A; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies' Eberhard Karls Universität Tübingen, 72076, Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076, Tübingen, Germany.; School of Pharmacy, University of Eastern Finland, 70210, Kuopio, Finland., Laufer SA; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany. stefan.laufer@uni-tuebingen.de.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies' Eberhard Karls Universität Tübingen, 72076, Tübingen, Germany. stefan.laufer@uni-tuebingen.de.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076, Tübingen, Germany. stefan.laufer@uni-tuebingen.de., Heppner DE; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. davidhep@buffalo.edu.; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA. davidhep@buffalo.edu.; Department of Structural Biology, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. davidhep@buffalo.edu.

Publikováno v: Communications chemistry [Commun Chem] 2024 Feb 20; Vol. 7 (1), pp. 38. Date of Electronic Publication: 2024 Feb 20.