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pro vyhledávání: '"Oli Abate Fulas"'
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background First-line pharmacotherapy for neuropathic pain entails the use of systemic antidepressants and anticonvulsants. These drugs are not optimally effective and poorly tolerated, especially for older patients with comorbid conditions.
Externí odkaz:
https://doaj.org/article/06f3df1d93094f7abe4f13fb44ffb47b
Autor:
Oli Abate Fulas, André Laferrière, Ghada Ayoub, Dayaker Gandrath, Cristina Mottillo, Hatem M. Titi, Robin S. Stein, Tomislav Friščić, Terence J. Coderre
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1144 (2020)
The discovery and development of effective analgesics is greatly lagging behind the steadily rising prevalence of chronic pain. Currently prescribed analgesics for chronic pain are lacking in efficacy mainly due to their narrowly-targeted mechanism o
Externí odkaz:
https://doaj.org/article/08a711eef4d24eb085dd0cf6cf39210e
Autor:
Oli Abate Fulas, Terence J. Coderre
Publikováno v:
Clinical Pain Management. :198-205
Publikováno v:
Journal of Neurochemistry. 152:570-584
Local microvascular dysfunction and consequent tissue ischemia/hypoxia contribute to the symptoms of complex regional pain syndrome (CRPS) and peripheral neuropathic pain. As nitric oxide (NO) is a key regulator of microvascular blood flow, compounds
Publikováno v:
ACS chemical neuroscience. 12(20)
Local tissue ischemic hypoxia is a peripheral process that can be targeted with topical treatment to alleviate pain under chronic pain conditions such as complex regional pain syndrome (CRPS) and peripheral neuropathic pain. We recently reported thre
Autor:
Robin S. Stein, Tomislav Friščić, Dayaker Gandrath, Cristina Mottillo, Oli Abate Fulas, Hatem M. Titi, André Laferrière, Ghada Ayoub, Terence J. Coderre
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 12, Iss 1144, p 1144 (2020)
Volume 12
Issue 12
Pharmaceutics, Vol 12, Iss 1144, p 1144 (2020)
Volume 12
Issue 12
The discovery and development of effective analgesics is greatly lagging behind the steadily rising prevalence of chronic pain. Currently prescribed analgesics for chronic pain are lacking in efficacy mainly due to their narrowly-targeted mechanism o
Publikováno v:
Trials
Trials, Vol 22, Iss 1, Pp 1-10 (2021)
Trials, Vol 22, Iss 1, Pp 1-10 (2021)
Background First-line pharmacotherapy for neuropathic pain entails the use of systemic antidepressants and anticonvulsants. These drugs are not optimally effective and poorly tolerated, especially for older patients with comorbid conditions. Given th
Autor:
Oli Abate Fulas, Manuela Schmidt, David Gomez-Varela, Pratibha Narayanan, Luca Avenali, Julia Sondermann
Publikováno v:
Channels (Austin, Tex.). 11(1)
The ability of sensory neurons to detect potentially harmful stimuli relies on specialized molecular signal detectors such as transient receptor potential (TRP) A1 ion channels. TRPA1 is critically implicated in vertebrate nociception and different p