Engineering of increased L-Threonine production in bacteria by combinatorial cloning and machine learning

Autor: Paul Hanke, Bruce Parrello, Olga Vasieva, Chase Akins, Philippe Chlenski, Gyorgy Babnigg, Chris Henry, Fatima Foflonker, Thomas Brettin, Dionysios Antonopoulos, Rick Stevens, Michael Fonstein

Publikováno v: Metabolic Engineering Communications, Vol 17, Iss , Pp e00225- (2023)

The goal of this study is to develop a general strategy for bacterial engineering using an integrated synthetic biology and machine learning (ML) approach. This strategy was developed in the context of increasing L-threonine production in Escherichia

Externí odkaz: https://doaj.org/article/7ecd1b4b29bf4bb09dc4bf3fb35386f3

Exploring Toxin Genes of Myanmar Russell’s Viper, Daboia siamensis, through De Novo Venom Gland Transcriptomics

Autor: Khin Than Yee, Jason Macrander, Olga Vasieva, Ponlapat Rojnuckarin

Publikováno v: Toxins, Vol 15, Iss 5, p 309 (2023)

The Russell’s viper (Daboia siamensis) is a medically important venomous snake in Myanmar. Next-generation sequencing (NGS) shows potential to investigate the venom complexity, giving deeper insights into snakebite pathogenesis and possible drug di

Externí odkaz: https://doaj.org/article/970a1a52557743e0823e9a8f89f08b43

Life without oxygen: gene regulatory responses of the crucian carp (Carassius carassius) heart subjected to chronic anoxia.

Autor: Kåre-Olav Stensløkken, Stian Ellefsen, Olga Vasieva, Yongxiang Fang, Anthony P Farrell, Lisa Olohan, Jarle Vaage, Göran E Nilsson, Andrew R Cossins

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e109978 (2014)

Crucian carp are unusual among vertebrates in surviving extended periods in the complete absence of molecular oxygen. During this time cardiac output is maintained though these mechanisms are not well understood. Using a high-density cDNA microarray,

Externí odkaz: https://doaj.org/article/346198defa6045c58a60853a917dcf86

PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth.

Autor: Anita Ciurciu, Louise Duncalf, Vincent Jonchere, Nick Lansdale, Olga Vasieva, Peter Glenday, Andreii Rudenko, Emese Vissi, Neville Cobbe, Luke Alphey, Daimark Bennett

Publikováno v: PLoS Genetics, Vol 9, Iss 10, p e1003885 (2013)

In multicellular organisms, tight regulation of gene expression ensures appropriate tissue and organismal growth throughout development. Reversible phosphorylation of the RNA Polymerase II (RNAPII) C-terminal domain (CTD) is critical for the regulati

Externí odkaz: https://doaj.org/article/c20a38da481d4c50ab7d3a6584542773

Using ASAR for Analysis of Electrogenic and Human Gut Microbial Communities

Autor: Igor Goryanin, Anatoly Sorokin, Olga Vasieva

Publikováno v: Scopus-Elsevier
Goryanin., I, Sorokin., A & Vasieva., O 2020, Using ASAR for Analysis of Electrogenic and Human Gut Microbial Communities . in Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies-BIOINFORMATICS, . vol. 3, pp. 253-259, 13th International Joint Conference on Biomedical Engineering Systems and Technologies, Valletta, Malta, 24/02/20 . https://doi.org/10.5220/0009193602530259

In this paper we describe applications of our ASAR package to functional, taxonomic and pathways analysis of metagenomes and propose future plans and perspectives. To illustrate an analytical potential of ASAR, we discuss outcomes of several projects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a4160b2ba9c9051ebf36027175d080
https://doi.org/10.5220/0009193602530259