Výsledky vyhledávání - "Olga V. Skabkina"

Interplay between Y-box-binding protein 1 (YB-1) and poly(A) binding protein (PABP) in specific regulation ofYB-1mRNA translation

Autor: Dmitry N. Lyabin, Lev P. Ovchinnikov, Olga V. Skabkina, Irina A. Eliseeva

Publikováno v: RNA Biology. 8:883-892

YB-1 is a DNA- and RNA-binding protein that regulates expression of many important genes. Its deficiency or excess may pose threats, including malignant cellular transformation and metastasis, which explains the necessity of strict control over its a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd2e1ebf5f786a0ea4a6b36073664db
https://doi.org/10.4161/rna.8.5.16022

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YB-1 Autoregulates Translation of Its Own mRNA at or prior to the Step of 40S Ribosomal Subunit Joining

Autor: Olga V. Skabkina, Lev P. Ovchinnikov, Dmitry N. Lyabin, Maxim A. Skabkin

Publikováno v: Molecular and Cellular Biology. 25:3317-3323

YB-1 is a member of the numerous families of proteins with an evolutionary ancient cold-shock domain. It is involved in many DNA- and RNA-dependent events and regulates gene expression at different levels. Previously, we found a regulatory element wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61f3a5ff3b707fdec9ee633abe38197
https://doi.org/10.1128/mcb.25.8.3317-3323.2005

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Poly(A)-binding Protein Positively Affects YB-1 mRNA Translation through Specific Interaction with YB-1 mRNA

Autor: Maxim A. Skabkin, Nadezhda V. Popova, Dmitry N. Lyabin, Lev P. Ovchinnikov, Luiz O. F. Penalva, Olga V. Skabkina

Publikováno v: Journal of Biological Chemistry. 278:18191-18198

The major protein of cytoplasmic mRNPs from rabbit reticulocytes, YB-1, is a member of an ancient family of proteins containing a common structural feature, cold-shock domain. In eukaryotes, this family is represented by multifunctional mRNA/Y-box DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92f1cd2421129b1a6084812e004b7ae
https://doi.org/10.1074/jbc.m209073200

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Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs

Autor: Tatyana V. Pestova, Olga V. Skabkina, Christopher U.T. Hellen, Parimal Kumar, Maxim A. Skabkin, Trevor R. Sweeney

Publikováno v: Nucleic Acids Research

Ribosomal recruitment of cellular mRNAs depends on binding of eIF4F to the mRNA’s 5′-terminal ‘cap’. The minimal ‘cap0’ consists of N7-methylguanosine linked to the first nucleotide via a 5′-5′ triphosphate (ppp) bridge. Cap0 is furth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5350a1b7a1d6682fda7b67251b8c4ea9
https://pubmed.ncbi.nlm.nih.gov/24371270

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Reinitiation and other unconventional posttermination events during eukaryotic translation

Autor: Christopher U.T. Hellen, Olga V. Skabkina, Maxim A. Skabkin, Tatyana V. Pestova

Publikováno v: Molecular cell. 51(2)

During ribosome recycling, post-termination complexes are dissociated by ABCE1 and eRF1 into 60S and tRNA/mRNA-associated 40S subunits, after which tRNA/mRNA are released by eIF1/eIF1A, Ligatin or MCT1/DENR. In some instances, 40S subunits remain ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d752da5baf696d96049bd526bac4fe93
https://pubmed.ncbi.nlm.nih.gov/23810859

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The mechanism of ribosome recycling in eukaryotes

Autor: Maxim A. Skabkin, Andrey V. Pisarev, Christopher U.T. Hellen, Olga V. Skabkina, Tatyana V. Pestova, Vera P. Pisareva

Publikováno v: Ribosomes ISBN: 9783709102145

Protein synthesis is a cyclical process, consisting of initiation, elongation, termination and ribosome recycling stages. Initiation requires pools of separated small and large ribosomal subunits, and it has been known for about forty years that, aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d24f2275e6495e24d17d9639c35d0f9e
https://doi.org/10.1007/978-3-7091-0215-2_14

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Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

Autor: Vidya Dhote, Maxim A. Skabkin, Anton A. Komar, Olga V. Skabkina, Tatyana V. Pestova, Christopher U.T. Hellen

Publikováno v: Genesdevelopment. 24(16)

Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNAMeti) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNAMeti/eIF2/GTP binds to 40S subunits yielding 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9e7647f2648ee8f867e4128d8f5e62
https://pubmed.ncbi.nlm.nih.gov/20713520

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The role of ABCE1 in eukaryotic posttermination ribosomal recycling

Autor: Tatyana V. Pestova, Andrey V. Pisarev, Christopher U.T. Hellen, Vera P. Pisareva, Olga V. Skabkina, Aurélie M. Rakotondrafara, Maxim A. Skabkin, Matthias W. Hentze

Publikováno v: Molecular cell. 37(2)

After termination, eukaryotic 80S ribosomes remain associated with mRNA, P-site deacylated tRNA, and release factor eRF1 and must be recycled by dissociating these ligands and separating ribosomes into subunits. Although recycling of eukaryotic postt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f737bf2a981444714b841d99a7014f
https://pubmed.ncbi.nlm.nih.gov/20122402

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