Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Olga V. Kel-Margoulis"'
Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer
Autor:
Leonid S. Leskov, Alexander E. Kel, Manel Esteller, Olga V. Kel-Margoulis, Ulyana A. Boyarskikh, Sebastian Moran, Philip Stegmaier, Daria Stelmashenko, Anna Martínez-Cardús, Nikita Mandrik, Jeannette Koschmann, Edgar Wingender, Andrey Sokolov, Fedor A. Kolpakov, Ivan S. Yevshin, Mathias Krull, Maxim L. Filipenko
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S4, Pp 1-20 (2019)
BMC Bioinformatics
BMC Bioinformatics
Background The search for molecular biomarkers of early-onset colorectal cancer (CRC) is an important but still quite challenging and unsolved task. Detection of CpG methylation in human DNA obtained from blood or stool has been proposed as a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d42cc2870eb3549008c9452f0b637c
http://link.springer.com/article/10.1186/s12859-019-2687-7
http://link.springer.com/article/10.1186/s12859-019-2687-7
Autor:
I.S. Evshin, A.S. Ryabova, S.S. Pintus, P. Stegmaier, I.N. Kiselev, Fedor Kolpakov, Biosoft, A.Е. Kel, J. Koschmann, M. Krull, R.N. Sharipov, E. Wingender, N.V. Mandrik, Olga V. Kel-Margoulis, D.E. Stelmashenko, N. Tandon
Publikováno v:
Laboratory and production. :76-86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca84b0d7b0d5ab8934d13295d72d7b6b
https://doi.org/10.32757/2619-0923.2019.3.7.76.86
https://doi.org/10.32757/2619-0923.2019.3.7.76.86
Autor:
Olga V. Kel-Margoulis, Jeannette Koschmann, Alexander E. Kel, Tagir Valeev, Philip Stegmaier, Vladimir Poroikov, Edgar Wingender
Publikováno v:
EuPA Open Proteomics
Graphical abstract
Highlights • Upstream analysis strategy for multi-omics data is proposed. • Drug targets are predicted by search for TFBS and analysis of signaling network. • Methotrexate resistance data include transcriptomics, proteom
Highlights • Upstream analysis strategy for multi-omics data is proposed. • Drug targets are predicted by search for TFBS and analysis of signaling network. • Methotrexate resistance data include transcriptomics, proteom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98443fac05aad1dbae490f870ef9d38a
https://doi.org/10.1016/j.euprot.2016.09.002
https://doi.org/10.1016/j.euprot.2016.09.002
Publikováno v:
SAR and QSAR in Environmental Research. 19:481-494
Different signal transduction pathways leading to the activation of transcription factors (TFs) converge at key molecules that master the regulation of many cellular processes. Such crossroads of signalling networks often appear as "Achilles Heels" c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784cfcbdb0ceb01223876040afebb943
https://doi.org/10.1080/10629360802083806
https://doi.org/10.1080/10629360802083806
Autor:
Alexander E. Kel, Olga V. Kel-Margoulis, Mikhail M. Savitski, Roman A. Zubarev, Michael L. Nielsen, Eva Fung, Edgar Wingender
Publikováno v:
Journal of Proteomics. 71:89-96
The availability of the results of high-throughput analyses coming from 'omic' technologies has been one of the major driving forces of pathway biology. Analytical pathway biology strives to design a 'pathway search engine', where the input is the 'o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbff9ee26e82114f606382dd0167625
https://doi.org/10.1016/j.jprot.2008.01.004
https://doi.org/10.1016/j.jprot.2008.01.004
Autor:
Alexander E. Kel, Olga V. Kel-Margoulis, Anatolij P Potapov, Jennifer Hogan, Torsten Crass, Edgar Wingender
Publikováno v:
Journal of Biosciences. 32:169-180
Bioinformatics has delivered great contributions to genome and genomics research, without which the world-wide success of this and other global ('omics') approaches would not have been possible. More recently, it has developed further towards the ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79df0a05045a849e7d2240564b2b257f
https://doi.org/10.1007/s12038-007-0015-2
https://doi.org/10.1007/s12038-007-0015-2
Autor:
Christoph Moehle, Olga V. Kel-Margoulis, Charalampos Aslanidis, Wolfgang Stremmel, Anna Schmitz-Madry, Nikolaus Ackermann, Alexandra Zahn, Gerd Schmitz, Alexander E. Kel, Thomas Langmann
Publikováno v:
Journal of Molecular Medicine. 84:1055-1066
Loss of intestinal mucosa integrity is an important factor in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to characterize expression changes and allelic variants of genes related to intestinal epithelial barrier fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2234ac3be6fba2b806e965707ffd332
https://doi.org/10.1007/s00109-006-0100-2
https://doi.org/10.1007/s00109-006-0100-2
Autor:
Tatiana Konovalova, Nico Voss, T. Waleev, Dmitry Shtokalo, Evgeny Cheremushkin, Philip Stegmaier, Alexander E. Kel, Edgar Wingender, Olga V. Kel-Margoulis
Publikováno v:
Nucleic Acids Research
Composite Module Analyst (CMA) is a novel software tool aiming to identify promoter-enhancer models based on the composition of transcription factor (TF) binding sites and their pairs. CMA is closely interconnected with the TRANSFAC® database. In pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6906f6c7bdb57f039a96beff57aea21e
https://doi.org/10.1093/nar/gkl342
https://doi.org/10.1093/nar/gkl342
Autor:
Deborah Kronenberg, Claudia Choi, Holger Michael, Olga V. Kel-Margoulis, Alexander E. Kel, Nico Voss, Mathias Krull, Anatolij P Potapov, Knut Schwarzer, Ingmar Reuter, Susanne Pistor, Edgar Wingender
Publikováno v:
Nucleic Acids Research
TRANSPATH[superscript ®] is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac180ba59ef4e33a87b34ebfc0ae72b
https://doi.org/10.1093/nar/gkj107
https://doi.org/10.1093/nar/gkj107
Publikováno v:
Handbook of Toxicogenomics: Strategies and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b338cc58f506371f465d8f6f35461d4f
https://doi.org/10.1002/3527603719.ch12
https://doi.org/10.1002/3527603719.ch12