Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Olga V, Hunter"'
Autor:
Anne M. Devlin, Ashutosh Shukla, Julio C. Ruiz, Spencer D. Barnes, Ashwin Govindan, Olga V. Hunter, Anna M. Scarborough, Iván D’Orso, Nicholas K. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The PNUTS-PP1 complex directly binds to RNA, and interacts with polymerase II and RNA processing factors to control transcriptional elongation rates and slow polymerase II after polyadenylation sites to promote termination. Using a genome-wide CRISPR
Externí odkaz:
https://doaj.org/article/c1f1e4399fcb427bafd71414e6943423
Autor:
Anna M Scarborough, Juliana N Flaherty, Olga V Hunter, Kuanqing Liu, Ashwani Kumar, Chao Xing, Benjamin P Tu, Nicholas K Conrad
Publikováno v:
eLife, Vol 10 (2021)
S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N6-adenosine methyltransferase
Externí odkaz:
https://doaj.org/article/ac2b0adbe78347f28a8d8a053ebe0d0d
Autor:
Sung-Kyun Park, Xiaorong Zhou, Kathryn E. Pendleton, Olga V. Hunter, Jennifer J. Kohler, Kathryn A. O’Donnell, Nicholas K. Conrad
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1088-1099 (2017)
Summary: Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mech
Externí odkaz:
https://doaj.org/article/0556ea66b2484836afad5c9c7b1f3fcc
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007596 (2019)
Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses
Externí odkaz:
https://doaj.org/article/5da153a3148942019e30282de03636b2
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005610 (2015)
The human nuclear poly(A)-binding protein PABPN1 has been implicated in the decay of nuclear noncoding RNAs (ncRNAs). In addition, PABPN1 promotes hyperadenylation by stimulating poly(A)-polymerases (PAPα/γ), but this activity has not previously be
Externí odkaz:
https://doaj.org/article/1091ce2dd313443782a8984af4ab9cc3
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004652 (2015)
The Kaposi's sarcoma associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi's sarcoma, primary effusion lymphoma (PEL), and some forms of multicentric Castleman's disease. The KSHV ORF57 protein is a conserved posttranscriptional regu
Externí odkaz:
https://doaj.org/article/0a1b62ba3e46404f9d1f86dfb47837f7
Autor:
Anna M. Scarborough, Chao Xing, Juliana N Flaherty, Nicholas K. Conrad, Kuanqing Liu, Benjamin P. Tu, Ashwani Kumar, Olga V. Hunter
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
SUMMARYS-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of the MAT2A RNA, which encodes only SAM synthetase expressed in most cells. The N6-ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78a47be38b4a248254d70d67f6f85d6
https://doi.org/10.1101/2020.11.12.380626
https://doi.org/10.1101/2020.11.12.380626
Autor:
Xiaorong Zhou, Nicholas K. Conrad, Jennifer J. Kohler, Kathryn A. O'Donnell, Sung Kyun Park, Olga V. Hunter, Kathryn E. Pendleton
Publikováno v:
Cell reports
Cell Reports, Vol 20, Iss 5, Pp 1088-1099 (2017)
Cell Reports, Vol 20, Iss 5, Pp 1088-1099 (2017)
Graphical abstract
Summary Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove
Summary Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c13933fe8c91d2d54248b0d6fdfa00
https://doi.org/10.1016/j.celrep.2017.07.017
https://doi.org/10.1016/j.celrep.2017.07.017
Publikováno v:
RNA (New York, N.Y.). 24(6)
Transcriptome analysis of human cells has revealed that intron retention controls the expression of a large number of genes with diverse cellular functions. Detained introns (DI) constitute a subgroup of transcripts with retained introns that are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02657bc2678bea55a491718a545c3d0a
https://pubmed.ncbi.nlm.nih.gov/29563249
https://pubmed.ncbi.nlm.nih.gov/29563249