Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity

Autor: Olga Taryma-Leśniak, Jan Bińkowski, Patrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Konrad Borowski, Tomasz Kazimierz Wojdacz

Publikováno v: Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-14 (2024)

Abstract Background It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumulation of locally disordered methylation at adjacent CpG sites is involved in neoplastic transformation, acting in sim

Externí odkaz: https://doaj.org/article/cfc82edcbb224bbfa6e2f4fc6101d676

Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection

Autor: Jan Bińkowski, Olga Taryma-Leśniak, Karolina Łuczkowska, Anna Niedzwiedź, Kacper Lechowicz, Dominik Strapagiel, Justyna Jarczak, Veronica Davalos, Aurora Pujol, Manel Esteller, Katarzyna Kotfis, Bogusław Machaliński, Miłosz Parczewski, Tomasz K. Wojdacz

Publikováno v: Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113396- (2022)

Recent studies have shown that methylation changes identified in blood cells of COVID-19 patients have a potential to be used as biomarkers of SARS-CoV-2 infection outcomes. However, different studies have reported different subsets of epigenetic les

Externí odkaz: https://doaj.org/article/e8ce83065b3445a99e8c3c45371ad3bd

Pan-Cancer Analysis of VIM Expression in Human Cancer Tissues

Autor: Beata Hukowska-Szematowicz, Malgorzata Blatkiewicz, Olga Taryma-Leśniak, Piotr Białas

In 2020, more than 19 million cancer cases were diagnosed. One of the best paths to more effective treatment with a chance of being cured for patients is early detection. Vimentin (VIM), as an intermediate filament protein, is broadly expressed in me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f2c228aaa73501c80fb62cb72f699b2
https://doi.org/10.21203/rs.3.rs-646169/v1

Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells

Autor: Karolina Łuczkowska, Olga Taryma-Leśniak, Jan Bińkowski, Katarzyna E. Sokołowska, Dominik Strapagiel, Justyna Jarczak, Edyta Paczkowska, Bogusław Machaliński, Tomasz K. Wojdacz

Publikováno v: Łuczkowska, K, Taryma-Leśniak, O, Bińkowski, J, Sokołowska, K E, Strapagiel, D, Jarczak, J, Paczkowska, E, Machaliński, B & Wojdacz, T K 2022, ' Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells ', Cancers, vol. 14, no. 14, 3402 . https://doi.org/10.3390/cancers14143402
Cancers; Volume 14; Issue 14; Pages: 3402

Bortezomib (BTZ) is proteasome inhibitor, effectively used in the treatment of multiple myeloma, but frequently discontinued due to peripheral neuropathy, which develops in patients after consecutive treatment cycles. The molecular mechanisms affecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defebff56eba7d83a4ae00a4ef55cccd
https://doi.org/10.3390/cancers14143402

Correction to: Current status of development of methylation biomarkers for in vitro diagnostic IVD applications

Autor: Tomasz K. Wojdacz, Olga Taryma-Leśniak, Katarzyna Ewa Sokolowska

Publikováno v: Clinical Epigenetics

A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition screening through early diagnostics to person

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e7ba6bd07829cd74e6ed3ef0ffd22d
http://europepmc.org/articles/PMC7362529