Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Olga Spadaro"'
Autor:
Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun-Hee Youm, Vishwa Deep Dixit
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous CR-mimetics that
Externí odkaz:
https://doaj.org/article/e954530dc5224073ad8d80f78f968471
Autor:
Olga Spadaro, Christina D. Camell, Lidia Bosurgi, Kim Y. Nguyen, Yun-Hee Youm, Carla V. Rothlin, Vishwa Deep Dixit
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 225-234 (2017)
Summary: In concert with their phagocytic activity, macrophages are thought to regulate the host immunometabolic responses primarily via their ability to produce specific cytokines and metabolites. Here, we show that IL-4-differentiated, M2-like macr
Externí odkaz:
https://doaj.org/article/d1ae4dcabacf4ca29f6d4d442d89bf39
Autor:
Hongyun Lu, Qinghua Zhou, Qiping Shi, Caixian Yang, Vishwa Deep Dixit, Xiaoyong Yang, Rachel J. Perry, Zhinan Yin, Dehai Li, Shengqi He, Yunfan Yang, Gerald I. Shulman, Cunchuan Wang, Hengwen Yang, Yong Liu, Hua Zhang, Hao Xu, Guangchao Cao, Ligong Lu, Zonghua Liu, Mingyue Zhang, Jing Zhu, Xiaoli Wu, Baocheng Wang, Libing Zhou, Hao Cheng, Qiong Wen, Richard A. Flavell, Guangqiang Li, Qian Wang, Yong Chen, Leqing Zhu, Yongjie Xin, Zhenyu Ju, Olga Spadaro
Publikováno v:
Nature. 600:314-318
Thermogenesis in brown and beige adipose tissue has important roles in maintaining body temperature and countering the development of metabolic disorders such as obesity and type 2 diabetes1,2. Although much is known about commitment and activation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bea8a8072059cc51047edfa2934ce4c
https://doi.org/10.1038/s41586-021-04127-5
https://doi.org/10.1038/s41586-021-04127-5
Autor:
Olga Spadaro, Vishwa Deep Dixit
Publikováno v:
Immunity. 50:13-15
The role of the immune system in homeostasis of pancreatic β cells in type 2 diabetes mellitus is poorly characterized. In a recent issue of Cell Metabolism, Ying et al. (2018) report that two subpopulations of macrophages expand during obesity to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226dc55e1609feb5672abdbf69fae577
https://doi.org/10.1016/j.immuni.2018.12.026
https://doi.org/10.1016/j.immuni.2018.12.026
Autor:
Yun-Hee Youm, Christina Camell, Jil Sander, Kim Y. Nguyen, Emily L. Goldberg, Matthew S. Rodeheffer, John D. Elsworth, Joachim L. Schultze, Allison Wing, Chester W. Brown, Aileen Lee, Vishwa Deep Dixit, Olga Spadaro
Publikováno v:
Nature 550(7674), 119-123 (2017). doi:10.1038/nature24022
Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the hydrolysis of triglycerides, declines with age. The defect in the mobilization of free fatty acids in the elderly is accompanied by increased visceral adipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b729d134a34c8aa98ecfd59c70cce2f
https://doi.org/10.1038/nature24022
https://doi.org/10.1038/nature24022
Autor:
Yun-Hee Youm, Christina Camell, Carla V. Rothlin, Vishwa Deep Dixit, Kim Y. Nguyen, Lidia Bosurgi, Olga Spadaro
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 225-234 (2017)
Summary: In concert with their phagocytic activity, macrophages are thought to regulate the host immunometabolic responses primarily via their ability to produce specific cytokines and metabolites. Here, we show that IL-4-differentiated, M2-like macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed987712d64204a9052f4cabb5f364d0
https://doi.org/10.1016/j.celrep.2017.03.046
https://doi.org/10.1016/j.celrep.2017.03.046
Autor:
Andrzej Bartke, P. Günther, Yun-Hee Youm, Christina Camell, J. L. Schultz, Yuji Ikeno, Emily L. Goldberg, Gene Hubbard, Olga Spadaro, Aileen Lee, Nancy H. Ruddle, Vishwa Deep Dixit
SummaryVisceral adiposity in elderly is associated with alterations in adipose tissue immune cells leading to inflammation and metabolic dysfunction. The Nlrp3 inflammasome is a critical regulator of macrophage activation, inflammation, and immunomet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d826a0f2a8e1cbdcd173ae31bf866f94
Autor:
Marcelo O. Dietrich, Maria Consolata Miletta, Caroline J. Zeiss, Vishwa Deep Dixit, Olga Spadaro, Giacomo Mancini, Matija Sestan-Pesa, Tamas L. Horvath, Luis Varela, Marya Shanabrough
Publikováno v:
Journal of the Endocrine Society
Anorexia Nervosa (AN) is an eating disorder characterized by severe hypophagia, high levels of physical activity, harsh weight loss and an intense fear of weight gain. It has the highest mortality rate among psychiatric illnesses and, due to the unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150bc83c66db266808569d34632b97cc
https://doi.org/10.1210/js.2019-sun-097
https://doi.org/10.1210/js.2019-sun-097
Autor:
Patrick Günther, Andrzej Bartke, Aileen Lee, Vishwa Deep Dixit, Yun-Hee Youm, Nancy H. Ruddle, Yuji Ikeno, Christina Camell, Joachim L. Schultze, Emily L. Goldberg, Gene Hubbard, Olga Spadaro
Publikováno v:
Cell metabolism 30(6), 1024-1039.e6 (2019). doi:10.1016/j.cmet.2019.10.006
During aging, visceral adiposity is often associated with alterations in adipose tissue (AT) leukocytes, inflammation, and metabolic dysfunction. However, the contribution of AT B cells in immunometabolism during aging is unexplored. Here, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f9d5ab379a221638b919ce9f2de7fb
https://doi.org/10.1016/j.cmet.2019.10.006
https://doi.org/10.1016/j.cmet.2019.10.006
Autor:
Vishwa Deep Dixit, Rachel J. Perry, Rebecca L. Cardone, Richard G. Kibbey, Rachel R. Kaspari, Giuseppe Ferrandino, Olga Spadaro, Andrea Reyna-Neyra, Nancy Carrasco, Gerald I. Shulman
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Hypothyroidism, a metabolic disease characterized by low thyroid hormone (TH) and high thyroid-stimulating hormone (TSH) levels in the serum, is strongly associated with nonalcoholic fatty liver disease (NAFLD). Hypothyroidism-induced NAFLD has gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec5a391ece56fffffb1420999f41b5
https://doi.org/10.1073/pnas.1707797114
https://doi.org/10.1073/pnas.1707797114