Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Olga Shubina"'
Autor:
Dariga Toluspayeva, Olga Shubina, Kulshira Apshe, Aliya Shukan, Gulara Nurguzhina, Asmagambetova Mirambaevna
Publikováno v:
International Journal of Society, Culture and Language, Vol 12, Iss 1, Pp 326-336 (2024)
The study presents an analysis of affixation in the morphological word-formation context of the English and Kazakh languages. Affixation is the process of adding affixes to the base word, which consequently leads to the formation of new words with ch
Externí odkaz:
https://doaj.org/article/e1fa910e40af4f04a5c1c9efb3526f87
Autor:
Irina Marcovich, Nicholas K. Baer, Olga Shubina-Oleinik, Rachel Eclov, Clayton W. Beard, Jeffrey R. Holt
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 914 (2022)
Gene therapy for genetic hearing loss is an emerging therapeutic modality for hearing restoration. However, the approach has not yet been translated into clinical application. To further develop inner-ear gene therapy, we engineered a novel mouse mod
Externí odkaz:
https://doaj.org/article/00a61c7bce904e8c98b967aafba56138
Autor:
Olga Shubina-Oleinik, Bernard L. Schneider, Carl Nist-Lund, Jeffrey R. Holt, Jason Wu, Sofia Spataro, Irina Marcovich, Paola Solanes, Hannah Goldberg
Publikováno v:
Molecular Therapy. 29:973-988
AAV-mediated gene therapy is a promising approach for treating genetic hearing loss. Replacement or editing of the Tmc1 gene, encoding hair cell mechanosensory ion channels, is effective for hearing restoration in mice with some limitations. Efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c84deaa561a6678190a83d127ca9a4
https://doi.org/10.1016/j.ymthe.2020.11.016
https://doi.org/10.1016/j.ymthe.2020.11.016
Publikováno v:
Lifelong Learning Book Series ISBN: 9783030985653
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78be2750157c3ffeca86c65376fe7c30
https://doi.org/10.1007/978-3-030-98566-0_2
https://doi.org/10.1007/978-3-030-98566-0_2
Publikováno v:
Journal of the Association for Research in Otolaryngology. 18:649-670
Gene therapy, or the treatment of human disease using genetic material, for inner ear dysfunction is coming of age. Recent progress in developing gene therapy treatments for genetic hearing loss has demonstrated tantalizing proof-of-principle in anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d75c882190afa1582a9979c530a760
https://doi.org/10.1007/s10162-017-0634-8
https://doi.org/10.1007/s10162-017-0634-8
Autor:
Jonathan C. Chen, Jonathan M. Levy, Rachel A. Burt, Gregory A. Newby, Olga Shubina-Oleinik, David R. Liu, Bifeng Pan, Jeffrey R. Holt, Michael Wornow, Wei-Hsi Yeh
Publikováno v:
Sci Transl Med
Most genetic diseases arise from recessive point mutations that require correction, rather than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to directly repair point mutations and provide therapeutic restor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5995f41202f51f5730858371e3b394
https://pubmed.ncbi.nlm.nih.gov/32514099
https://pubmed.ncbi.nlm.nih.gov/32514099
Autor:
Christine R. Zheng, Luke W. Koblan, Jonathan M. Levy, Olga Shubina-Oleinik, Wei-Hsi Yeh, Christine D. Wilson, Gregory A. Newby, Jeffrey R. Holt, Benjamin W. Thuronyi, Mantu Bhaumik, David R. Liu
Publikováno v:
Nature biotechnology
Base editors use DNA-modifying enzymes targeted with a catalytically impaired CRISPR protein to precisely install point mutations. Here, we develop phage-assisted continuous evolution of base editors (BE-PACE) to improve their editing efficiency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495b2c9bf2f0a89d0c7ac17b0d7fc1e3
https://pubmed.ncbi.nlm.nih.gov/31406330
https://pubmed.ncbi.nlm.nih.gov/31406330
Autor:
M. G. Siniauskaya, Nina Danilenko, Olga Shubina-Oleinik, O. G. Davydenko, Elena Merkulava, Anastasia Levaya-Smaliak
Publikováno v:
Journal of Hearing Science. 4:24-29
BackgroundThe splice site nucleotide substitution IVS1+1G>A in the non-coding part of the GJB2 gene is one of the recessive pathogenic mutations causing nonsyndromic sensorineural hearing loss (NSHL). We present here the results of a study of IVS1+1G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340410782fef3507722c4e6df470e271
https://doi.org/10.17430/891018
https://doi.org/10.17430/891018
Autor:
Luke W. Koblan, Christine D. Wilson, Benjamin W. Thuronyi, Mantu Bhaumik, David R. Liu, Gregory A. Newby, Olga Shubina-Oleinik, Jeffrey R. Holt, Jonathan M. Levy, Wei-Hsi Yeh, Christine R. Zheng
Publikováno v:
Nature Biotechnology. 37:1091-1091
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ff4c497e14293c035a2a7369f7ec69
https://doi.org/10.1038/s41587-019-0253-5
https://doi.org/10.1038/s41587-019-0253-5
Autor:
Michael G. Shlyapnikov, Igor Granovsky, Konstantin Pyatkov, Olga Shubina, Tamara Shcherbakova, V P Shcherbakov, Plugina La, Svetlana V. Sizova
Publikováno v:
Genetics. 162(2)
A model system for studying double-strand-break (DSB)-induced genetic recombination in vivo based on the ets1 segCΔ strain of bacteriophage T4 was developed. The ets1, a 66-bp DNA fragment of phage T2L containing the cleavage site for the T4 SegC si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca89ff8ce45731712e1d0f428c22efb
https://pubmed.ncbi.nlm.nih.gov/12399370
https://pubmed.ncbi.nlm.nih.gov/12399370