Compassionate use of tocilizumab in severe SARS-CoV2 pneumonia

Autor: Miguel Górgolas Hernández-Mora, Alfonso Cabello Úbeda, Laura Prieto-Pérez, Felipe Villar Álvarez, Beatriz Álvarez Álvarez, María Jesús Rodríguez Nieto, Irene Carrillo Acosta, Itziar Fernández Ormaechea, Aws Waleed Mohammed Al-Hayani, Pilar Carballosa, Silvia Calpena Martínez, Farah Ezzine, Marina Castellanos González, Alba Naya, Marta López De Las Heras, Marcel José Rodríguez Guzmán, Ana Cordero Guijarro, Antonio Broncano Lavado, Alicia Macías Valcayo, Marta Martín García, Javier Bécares Martínez, Ricardo Fernández Roblas, Miguel Ángel Piris Pinilla, José Fortes Alen, Olga Sánchez Pernaute, Fredeswinda Romero Bueno, Sarah Heili-Frades, Germán Peces-Barba Romero

Publikováno v: International Journal of Infectious Diseases, Vol 102, Iss , Pp 303-309 (2021)

Introduction: Tocilizumab (TCZ) is an interleukin-6 receptor antagonist, which has been used for the treatment of severe SARS-CoV-2 pneumonia (SSP), which aims to ameliorate the cytokine release syndrome (CRS) induced acute respiratory distress syndr

Externí odkaz: https://doaj.org/article/2aae212706174c78b0f4443668f39cdb

Unravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocol

Autor: José M Castellano, Marek Majdan, In-Hwan Oh, John Kelleher, Saša Missoni, Natalija Novokmet, Ella Arensman, João Silva, Guy Fagherazzi, Marianne Van Der Sande, Silvia Riva, Joan B Soriano, David M. Pereira, Julio Ancochea, Michel Vaillant, Jörn Klein, Brecht Devleesschauwer, Patrick Soentjens, Ernestina Menasalvas, Justo Menéndez, Antigona Carmen Trofor, Olga Sánchez-Pernaute, Mihaela Lupse, Dora Buonfrate, Zubair Kabir, Jose L Penalvo, Miguel Górgolas, Paula Villares, Lucia Maria Lotrean, Lucía Llanos, Costas Tsiamis, Seval Akgün, Tamara Ursini, José L. Peñalvo, Elly Mertens, Diana Sagastume, Jelena Dimnjaković, Marija Švajda, Tamara Poljičanin, Jelena Sarac, Enisa Ademović, Ana Lúcia Baltazar, Miran Čoklo, Paula Andrea Diaz Valencia, João C. Fernandes, Enrique Javier Gómez, Paul Hynds, Polychronis Kostoulas, Lucía Llanos Jiménez, Paul Nguewa, Georgie O’Sullivan, Miguel Reina Ortiz, Gloria Soriano, Joan B. Soriano, Fernando Spilki, Mary Elizabeth Tamang, Sabrina Van Ierssel, Jakov Vuković, José M. Castellano, James Cottam, Hanne Van Tiggelen, José Barberán, Mercedes Villareal, Nerea Ruiz del Árbol, Alberto Estirado, Alberto Blázquez Herranz, David Fernandez Lobón, Paloma Chausa, David M Pereira, Morteza Hosseini, Elizabeth Hunter, Brendan Palmer, Milena Man, Mira Florea, Andrei Tudor Cernomaz, Radu Adrian Crisan-Dabija, Cristina Grigorescu, João C Fernandes, Daria Rabarova, Adriana Krsakova, Jaroslava Brnova, Janka Prnova, Jaroslav Slany, Dominika Plancikova, Nisa Boukichou Abdelkader, Adrián Peláez, Elena Ávalos, Gorane Iturricastillo, Arnoldo Santos Oviedo, Sergio Luis Lima, Antonio Herrero, Pablo Minguez, Olympia Lioupi, Eleftherios Meletis, Konstantinos Pateras, Mustafa Asfari, Nicoletta De Santis, Petronille Bogaert, Koen Blot, Miriam Saso, Mathil Vandromme, Ivan Pristas, Marko Brkic, Luka Bočkor, Ivan Dolanc, Antonija Jonjić, Iva Šunić, Tugba Gürgen Erdogan, Süleyman Çetinkünar, Cenk Belibağlı, Kübra Demir, Mustafa Görür, Turgut Bulut, K R NayarSilvia Riva, Carlo Giordani, Petra Golin, Oh In-Hwan, Seok Jun Yoon, Lina Ruíz, Juan Pablo Pérez Bedoya, Oscar Ignacio Mendoza, Camilo Hincapie, Boris Rodriguez, Noël Barengo, Juliane Deise Fleck, Matheus Nunes Weber, Lejla Burnazović-Ristić, Semra Čavaljuga, Džan Ahmed Jesenković, Lejla Džananović

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Introduction unCoVer—Unravelling data for rapid evidence-based response to COVID-19—is a Horizon 2020-funded network of 29 partners from 18 countries capable of collecting and using real-world data (RWD) derived from the response and provision of

Externí odkaz: https://doaj.org/article/c9e54ac90148496b8a6f0e5f43c36235

First and Second Waves of Coronavirus Disease 2019 in Madrid, Spain: Clinical Characteristics and Hematological Risk Factors Associated With Critical/Fatal Illness

Autor: Irene Mollinedo-Gajate, PhD, Felipe Villar-Álvarez, MD, PhD, María de los Ángeles Zambrano-Chacón, MD, Laura Núñez-García, MD, Laura de la Dueña-Muñoz, MD, Carlos López-Chang, MD, Miguel Górgolas, MD, PhD, Alfonso Cabello, MD, PhD, Olga Sánchez-Pernaute, MD, PhD, Fredeswinda Romero-Bueno, MD, PhD, Álvaro Aceña, MD, PhD, Nicolás González-Mangado, MD, PhD, Germán Peces-Barba, MD, PhD, Faustino Mollinedo, PhD

Publikováno v: Critical Care Explorations, Vol 3, Iss 2, p e0346 (2021)

Objectives:. This study aims to determine similarities and differences in clinical characteristics between the patients from two waves of severe acute respiratory syndrome coronavirus-2 infection at the time of hospital admission, as well as to ident

Externí odkaz: https://doaj.org/article/cf84742930ff423bb29ef96c40f42bee

Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation

Autor: Sandra Pérez-Baos, Iván Prieto-Potin, Jorge A. Román-Blas, Olga Sánchez-Pernaute, Raquel Largo, Gabriel Herrero-Beaumont

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Besides its primary function in locomotion, skeletal muscle (SKM), which represents up to half of human's weight, also plays a fundamental homeostatic role. Through the secretion of soluble peptides, or myokines, SKM interacts with major organs invol

Externí odkaz: https://doaj.org/article/ac9faf1497e84af799d8d6e63266dc24

Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns

Autor: José Luis Álvarez-Sala, Lydia Abasolo, Cristina Vadillo, Leticia Leon, Juan Angel Jover, María Jesús Rodríguez-Nieto, Dalifer Freites-Núñez, Fredeswinda Romero-Bueno, Maria Asuncion Nieto, Olga Sánchez-Pernaute

Publikováno v: BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Pulmonary Medicine

Background To assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality. Methods A longitudinal multicen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a105fcb5563551ffd1d384c8b0fa0230
https://doaj.org/article/b390e0f9a0be48eb80db57d08694500a