Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Olga S, Blomberg"'
Autor:
Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the sys
Externí odkaz:
https://doaj.org/article/b656e036ddb5458b8a3bb50ca339a61b
Autor:
Jessica R. Ingram, Michael Dougan, Mohammad Rashidian, Marko Knoll, Edmund J. Keliher, Sarah Garrett, Scott Garforth, Olga S. Blomberg, Camilo Espinosa, Atul Bhan, Steven C. Almo, Ralph Weissleder, Harvey Lodish, Stephanie K. Dougan, Hidde L. Ploegh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Current approaches to visualise brown adipose tissue (BAT) rely primarily on markers that reflect its metabolic activity. Here, the authors show that PD-L1 is expressed on brown adipocytes, does not change upon BAT activation, and that BAT volume in
Externí odkaz:
https://doaj.org/article/2cbbcd069f884ad59674351eae9c1223
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 10 (2018)
Metastatic disease is the leading cause of death in cancer patients. Metastasis formation involves a cascade of events for which the underlying mechanisms are still poorly understood. During the metastatic cascade, cancer cells tightly interact with
Externí odkaz:
https://doaj.org/article/34182114361144ec9f4d7df56facc653
Autor:
Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, Kelly Kersten, Marieke Brüggemann, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth A.M. Raeven, Daphne Kaldenbach, Kevin Kos, Inna S. Afonina, Paulien Kaptein, Louisa Hoes, Willemijn S.M.E. Theelen, Paul Baas, Emile E. Voest, Rudi Beyaert, Daniela S. Thommen, Lodewyk F.A. Wessels, Karin E. de Visser, Marleen Kok
Publikováno v:
CANCER CELL
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Autor:
Olga S, Blomberg, Lorenzo, Spagnuolo, Hannah, Garner, Leonie, Voorwerk, Olga I, Isaeva, Ewald, van Dyk, Noor, Bakker, Myriam, Chalabi, Chris, Klaver, Maxime, Duijst, Kelly, Kersten, Marieke, Brüggemann, Dorien, Pastoors, Cheei-Sing, Hau, Kim, Vrijland, Elisabeth A M, Raeven, Daphne, Kaldenbach, Kevin, Kos, Inna S, Afonina, Paulien, Kaptein, Louisa, Hoes, Willemijn S M E, Theelen, Paul, Baas, Emile E, Voest, Rudi, Beyaert, Daniela S, Thommen, Lodewyk F A, Wessels, Karin E, de Visser, Marleen, Kok
Publikováno v:
Cancer cell.
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Autor:
Quang-Dé Nguyen, Ulrich H. von Andrian, Novalia Pishesha, Michael Dougan, Olga S. Blomberg, Munir Mosaheb, Paul M Tyler, Hidde L. Ploegh, Patrick T. Bruck, Mariah M. Servos, Jessica R. Ingram, Hee-Jin Jeong, Mohammad Rashidian, Lestat R. Ali, Stephanie K. Dougan
Publikováno v:
Cancer Immunology Research. 6:389-401
Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment.
Autor:
Atul K. Bhan, Hidde L. Ploegh, Ralph Weissleder, Camilo Espinosa, Edmund J. Keliher, Mohammad Rashidian, Steven C. Almo, Marko Knoll, Scott J. Garforth, Michael Dougan, Stephanie K. Dougan, Olga S. Blomberg, Sarah C. Garrett, Jessica R. Ingram, Harvey F. Lodish
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Programmed death ligand 1 (PD-L1) is expressed on a number of immune and cancer cells, where it can downregulate antitumor immune responses. Its expression has been linked to metabolic changes in these cells. Here we develop a radiolabeled camelid si
Autor:
Ivo J. Huijbers, Heinz Jacobs, Bas Pilzecker, Olga S. Blomberg, Olimpia Alessandra Buoninfante, Colin Pritchard, Paul C.M. van den Berk
Publikováno v:
Nucleic Acids Research
PrimPol is a DNA damage tolerant polymerase displaying both translesion synthesis (TLS) and (re)-priming properties. This led us to study the consequences of a PrimPol deficiency in tolerating mutagenic lesions induced by members of the APOBEC/AID fa
Autor:
Leonie Voorwerk, Olga S. Blomberg, L. Spagnuolo, M.S. van der Heijden, M. Duijst, Emile E. Voest, E. van Dyk, J. van Dorp, K.E. De Visser, Olga I. Isaeva, Marleen Kok, Myriam Chalabi, Hannah Garner, Lodewyk F. A. Wessels, Kelly Kersten, C. Klaver, Noor A. M. Bakker, L.R. Hoes, Willemijn S. M. E. Theelen
Publikováno v:
Annals of Oncology. 31:S1142
Autor:
Tamara Biary, Steven C. Almo, Edmund J. Keliher, Stephanie J. Crowley, Elena V. Fedorov, Alexander A. Fedorov, Stephanie K. Dougan, Jessica R. Ingram, Mohammad Rashidian, Lestat R. Ali, Hidde L. Ploegh, Ralph Weissleder, Scott J. Garforth, Olga S. Blomberg, Michael Dougan, Jeffrey B. Bonanno, Camilo Espinosa, Camille Le Gall
Publikováno v:
Proceedings of the National Academy of Sciences USA, 115, 15, pp. 3912-3917
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences USA, 115, 3912-3917
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences USA, 115, 3912-3917
Significance Ipilimumab, an antibody that recognizes cytotoxic T lymphocyte antigen (CTLA)-4, was the first approved “checkpoint”-blocking anticancer therapy. In mice, the response to antibodies against CTLA-4 depends entirely on expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912016cfc32823bb4629ac0882c947bb
https://hdl.handle.net/2066/200578
https://hdl.handle.net/2066/200578