Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Olga Perisic"'
Autor:
Shirley Tremel, Yohei Ohashi, Dustin R. Morado, Jessie Bertram, Olga Perisic, Laura T. L. Brandt, Marie-Kristin von Wrisberg, Zhuo A. Chen, Sarah L. Maslen, Oleksiy Kovtun, Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A. G. Briggs, Roger L. Williams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34
Externí odkaz:
https://doaj.org/article/d0b77c3d6f3f4cfcbbaf6326c8d008f3
Autor:
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Publikováno v:
eLife, Vol 10 (2021)
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find t
Externí odkaz:
https://doaj.org/article/f3e3156092d447fd9fa28ea08dad4816
Autor:
Wen-Ting Lo, Hassane Belabed, Murat Kücükdisli, Juliane Metag, Yvette Roske, Polina Prokofeva, Yohei Ohashi, André Horatscheck, Davide Cirillo, Michael Krauss, Christopher Schmied, Martin Neuenschwander, Jens Peter von Kries, Guillaume Médard, Bernhard Kuster, Olga Perisic, Roger L. Williams, Oliver Daumke, Bernard Payrastre, Sonia Severin, Marc Nazaré, Volker Haucke
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet morpholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e2f007efebfff9a9b182e223cbec7b
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
Autor:
Madhanagopal Anandapadamanaban, Andreas Boland, Alex Berndt, Olga Perisic, Xiaodan Ni, Stefan M.V. Freund, Jane L. Wagstaff, Roger L. Williams, Sarah L. Maslen, Stephen H. McLaughlin, Keitaro Yamashita, Conny Wing-Heng Yu, Mark Skehel, Maren Heimhalt, Garib N. Murshudov, Glenn R. Masson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63a7d4c77d781be24fc078b87ff7f22
https://doi.org/10.7554/elife.68799.sa2
https://doi.org/10.7554/elife.68799.sa2
Autor:
Julian Downward, Phillip T. Hawkins, Olga Perisic, Sabine Suire, Len R. Stephens, Suhasini Kulkarni, David Oxley, T. N. Durrant, N. Tsolakos, Roger L. Williams, Tamara Chessa
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The class IA PI3Ks, comprised of regulatory (p85α/p85β/p55γ) and catalytic (p110α/β/δ) subunits, which make the signaling lipid PIP3, constitute a key node in signaling. Many factors underlie their numerous cellular roles and large
Autor:
Alex Berndt, Madhanagopal Anandapadamanaban, Keitaro Yamashita, Sarah L. Maslen, Mark Skehel, Glenn R. Masson, Stefan M.V. Freund, Maren Heimhalt, Garib N. Murshudov, Roger L. Williams, Olga Perisic, Conny Wing-Heng Yu, Xiaodan Ni, Jane L. Wagstaff, Stephen H. McLaughlin, Andreas Boland
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
mTORC1 is a kinase complex regulating cell growth, proliferation and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb36120c04dfaa3fc5886b70680a712c
https://doi.org/10.1101/2021.04.28.441853
https://doi.org/10.1101/2021.04.28.441853
Autor:
Marie-Kristin von Wrisberg, Juri Rappsilber, Olga Perisic, Roger L. Williams, Sarah L. Maslen, Dustin R. Morado, John A. G. Briggs, Kathrin Lang, Jessie Bertram, Shirley Tremel, Sean Munro, Mark Skehel, Oleksiy Kovtun, Yohei Ohashi, Zhuo A. Chen, Laura T L Brandt
Publikováno v:
Nature Communications, 12
Tremel, S, Ohashi, Y, Morado, D R, Bertram, J, Perisic, O, Brandt, L T L, von Wrisberg, M K, Chen, Z A, Maslen, S L, Kovtun, O, Skehel, M, Rappsilber, J, Lang, K, Munro, S, Briggs, J A G & Williams, R L 2021, ' Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes ', Nature Communications, vol. 12, 1564 . https://doi.org/10.1038/s41467-021-21695-2
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Tremel, S, Ohashi, Y, Morado, D R, Bertram, J, Perisic, O, Brandt, L T L, von Wrisberg, M K, Chen, Z A, Maslen, S L, Kovtun, O, Skehel, M, Rappsilber, J, Lang, K, Munro, S, Briggs, J A G & Williams, R L 2021, ' Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes ', Nature Communications, vol. 12, 1564 . https://doi.org/10.1038/s41467-021-21695-2
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f817ee0df381ae701383613316007446
https://hdl.handle.net/20.500.11850/529518
https://hdl.handle.net/20.500.11850/529518
Autor:
Balaji Santhanam, Kacper B. Rogala, David M. Sabatini, Alex Berndt, Roger L. Williams, Glenn R. Masson, Olga Perisic, Christopher M. Johnson, Madhanagopal Anandapadamanaban, Jonathan Kaufman
Publikováno v:
PMC
Mastering regulation The mechanistic target of rapamycin complex 1 (mTORC1) is known as the master kinase, acknowledging its key role in integrating multiple signals to regulate cell growth. When nutrients are abundant, heterodimers of Rag, a class o
Autor:
Sichen Shao, Olga Perisic, Glenn R. Masson, Stephen H. McLaughlin, Roger L. Williams, Alison J. Inglis, Ramanujan S. Hegde
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance General control nonderepressible 2 (GCN2) phosphorylates eIF2α, regulating translation in response to nutritional stress. Here, we show that although tRNA stimulates purified, recombinant human GCN2 in vitro, mammalian ribosomes are eve
Autor:
Carsten Sachse, Nicholas T. Ktistakis, Marie L. Kirsten, Lufei Zhang, Miguel García Ortegón, Olga Perisic, Maki Ohashi, Apostolos A. Apostolakis, Nicolas Soler, Glenn R. Masson, John E. Burke, Yohei Ohashi, Roger L. Williams, Christopher M. Johnson, Arjen J. Jakobi
Publikováno v:
'Autophagy ', vol: 12, pages: 2129-2144 (2016)
Autophagy
Autophagy
The phosphatidylinositol 3-kinase Vps34 is part of several protein complexes. The structural organization of heterotetrameric complexes is starting to emerge, but little is known about organization of additional accessory subunits that interact with