Výsledky vyhledávání - "Olga Papaioannou"

Akademický článek

Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator

Autor: Bertrand Kleizen, Eduardo de Mattos, Olga Papaioannou, Michele Monti, Gian Gaetano Tartaglia, Peter van der Sluijs, Ineke Braakman

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 21, p 15741 (2023)

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a large multi-spanning membrane protein that is susceptible to misfolding and aggregation. We have identified here the region responsible for this instability. Temperature-induced aggr

Externí odkaz: https://doaj.org/article/35296191939b461cb85b9dcd521552f2

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The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design

Autor: Eszter Szennyes, Efthimios Kyriakis, Vassiliki T. Skamnaki, Olga Papaioannou, Éva Bokor, Theodora G.A. Solovou, Spyros E. Zographos, László Somsák, Panagiota G.V. Liggri, Demetres D. Leonidas, Sándor Kun, Aikaterini G. Karra, Anna-Maria G. Psarra

Publikováno v: Bioorganicmedicinal chemistry. 28(1)

C-Glucopyranosyl imidazoles, thiazoles, and an N-glucopyranosyl tetrazole were assessed in vitro and ex vivo for their inhibitory efficiency against isoforms of glycogen phosphorylase (GP; a validated pharmacological target for the development of ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4668a1579d2f4974b48abe933c6b9ec
https://pubmed.ncbi.nlm.nih.gov/31767404

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