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Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs

Autor: Bela Kiss, Attila Horváth, Zsolt Szombathelyi, Katalin Nogradi, Olga Nyéki, István Greiner, Csaba Wéber, Gábor Wágner, Dalma Kurkó, József Nagy, Amrita Ágnes Bobok, Sándor Kolok, Attila Bielik, Krisztina Gál, György M. Keserű, György Domány, László Molnár

Publikováno v: Bioorganicmedicinal chemistry letters. 20(12)

Here we report the discovery and early SAR of a series of mGluR5 negative allosteric modulators (NAMs). Starting from a moderately active HTS hit we synthesized 3,5-disubstituted-oxadiazoles and tetrazoles as mGluR5 NAMs. Based on the analysis of lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc883ec940059d979f0a9861d34330ed
https://pubmed.ncbi.nlm.nih.gov/20483612

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Copper(II) complexes of low molecular weight derivatives of thymopoietin

Autor: Imre Sóvágó, Csilla Bertalan, László Gobi, Olga Nyéki

Publikováno v: Journal of inorganic biochemistry. 55(1)

Copper(II) complexes of tri- and tetrapeptides containing either carboxylate or amide group in the side chain were studied by potentiometric and spectroscopic methods. The ligands are tri- and tetrapeptide segments of the hormones thymopoietin and sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cb50c4aad3cb6b8cd0de5e720f5dd3
https://pubmed.ncbi.nlm.nih.gov/8046437

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