Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Olga N Pakhomova"'
Publikováno v:
Cell Stress, Vol 8, Pp 69-82 (2024)
Exceeding physiological limits of the cell membrane potential compromises structural integrity, enabling the passage of normally impermeant solutes and disrupting cell function. Electropermeabilization has been studied extensively at the cellular sca
Externí odkaz:
https://doaj.org/article/55b6e8adaf35419c9ed03a5de82da14e
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159434 (2016)
Electroporation-induced cell sensitization was described as the occurrence of a delayed hypersensitivity to electric pulses caused by pretreating cells with electric pulses. It was achieved by increasing the duration of the electroporation treatment
Externí odkaz:
https://doaj.org/article/5952efe560d24f9da9089303cce0bb7c
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70278 (2013)
High-amplitude electric pulses of nanosecond duration, also known as nanosecond pulsed electric field (nsPEF), are a novel modality with promising applications for cell stimulation and tissue ablation. However, key mechanisms responsible for the cyto
Externí odkaz:
https://doaj.org/article/70c3b3bfeb6b4b9c87be86ba1912073e
Autor:
Olga N Pakhomova, Betsy W Gregory, Vera A Khorokhorina, Angela M Bowman, Shu Xiao, Andrei G Pakhomov
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17100 (2011)
Electroporation is a method of disrupting the integrity of cell membrane by electric pulses (EPs). Electrical modeling is widely employed to explain and study electroporation, but even most advanced models show limited predictive power. No studies ha
Externí odkaz:
https://doaj.org/article/1d631789cf5542899672b39370ee6443
Autor:
Bennett L Ibey, Caleb C Roth, Andrei G Pakhomov, Joshua A Bernhard, Gerald J Wilmink, Olga N Pakhomova
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15642 (2011)
In this study, we determined the LD(50) (50% lethal dose) for cell death, and the ED(50) (50% of cell population staining positive) for propidium (Pr) iodide uptake, and phosphatidylserine (PS) externalization for several commonly studied cell lines
Externí odkaz:
https://doaj.org/article/2d3e38b681934ae4b56b0d1f3eda6e70
Autor:
Pamela W. Sowa, Aleksander S. Kiełbik, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Volker Adams, Olga N. Pakhomova
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome. Copolymers such as Poloxamer 188 (P188) are known to preserve the membrane i
Externí odkaz:
https://doaj.org/article/358634790a3b4390b8c7673860881b99
Autor:
Aleksander Kiełbik, Pamela W. Sowa, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Julita Kulbacka, Olga N. Pakhomova
Publikováno v:
Bioelectrochemistry (Amsterdam, Netherlands). 149
The quest for safe and effective ablation resulted in the development of nanosecond pulsed electric fields (nsPEF) technology for tumor treatment. For future applications of nsPEF in urothelial cancer treatment, we evaluated the effect of urine prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb4f44740c24d59c06295212d14db95
https://pubmed.ncbi.nlm.nih.gov/36270049
https://pubmed.ncbi.nlm.nih.gov/36270049
Autor:
Sayak, Bhattacharya, Mantas, Silkunas, Emily, Gudvangen, Uma, Mangalanathan, Olga N, Pakhomova, Andrei G, Pakhomov
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1864(2)
Electroporation, in particular with nanosecond pulses, is an efficient technique to generate nanometer-size membrane lesions without the use of toxins or other chemicals. The restoration of the membrane integrity takes minutes and is only partially d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe67df51915eb97a6ac6c617aa798f56
https://pubmed.ncbi.nlm.nih.gov/34838875
https://pubmed.ncbi.nlm.nih.gov/34838875
Publikováno v:
Bioelectrochemistry (Amsterdam, Netherlands). 140
Exposure of living cells to intense nanosecond pulsed electric field (nsPEF) increases membrane permeability to small solutes, presumably by the formation of nanometer-size membrane lesions. Mechanisms responsible for the restoration of membrane inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfafa9985eb0974db03cbc6d991fc2b2
https://pubmed.ncbi.nlm.nih.gov/34004548
https://pubmed.ncbi.nlm.nih.gov/34004548
Autor:
Olga N. Pakhomova, Maura Casciola, Uma Mangalanathan, Wenfei Bo, Shu Xiao, Mantas Silkunas, Andrei G. Pakhomov, Iurii Semenov, Vitalij Novickij
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3386, p 3386 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 9
International journal of molecular sciences, Basel : MDPI, 2020, vol. 21, 3386, p. 2-17
International Journal of Molecular Sciences
Volume 21
Issue 9
International journal of molecular sciences, Basel : MDPI, 2020, vol. 21, 3386, p. 2-17
The principal bioeffect of the nanosecond pulsed electric field (nsPEF) is a lasting cell membrane permeabilization, which is often attributed to the formation of nanometer-sized pores. Such pores may be too small for detection by the uptake of fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c7c15942bbd24f94957391701f428d
http://dspace.vgtu.lt/handle/1/3989
http://dspace.vgtu.lt/handle/1/3989
