Deletions of conserved extracytoplasmic function sigma factors-encoding genes in Streptomyces have a major impact on secondary metabolism

Autor: Olga N. Sekurova, Martin Zehl, Michael Predl, Peter Hunyadi, Thomas Rattei, Sergey B. Zotchev

Publikováno v: Microbial Cell Factories, Vol 23, Iss 1, Pp 1-18 (2024)

Abstract Background Ethanol shock significantly affects expression of over 1200 genes in Streptomyces venezuelae NRRL B-65,442, including those involved in secondary metabolite biosynthesis and a cryptic gene pepX, which encodes a 19-amino acid pepti

Externí odkaz: https://doaj.org/article/f4e15a61c1b749dca1346fe282f70e8d

Novel bioactive natural products from bacteria via bioprospecting, genome mining and metabolic engineering

Autor: Olga N. Sekurova, Olha Schneider, Sergey B. Zotchev

Publikováno v: Microbial Biotechnology, Vol 12, Iss 5, Pp 828-844 (2019)

Summary For over seven decades, bacteria served as a valuable source of bioactive natural products some of which were eventually developed into drugs to treat infections, cancer and immune system‐related diseases. Traditionally, novel compounds pro

Externí odkaz: https://doaj.org/article/d15aaa80369a4632a16d98069d126206

Genomics of sponge-associated Streptomyces spp. closely related to Streptomyces albus J1074: insights into marine adaptation and secondary metabolite biosynthesis potential.

Autor: Elena Ian, Dmitry B Malko, Olga N Sekurova, Harald Bredholt, Christian Rückert, Marina E Borisova, Andreas Albersmeier, Jörn Kalinowski, Mikhail S Gelfand, Sergey B Zotchev

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96719 (2014)

A total of 74 actinomycete isolates were cultivated from two marine sponges, Geodia barretti and Phakellia ventilabrum collected at the same spot at the bottom of the Trondheim fjord (Norway). Phylogenetic analyses of sponge-associated actinomycetes

Externí odkaz: https://doaj.org/article/72dc8d9c5f23463bb9699edf61e790e9

New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07

Autor: Olga N. Sekurova, Ignacio Pérez-Victoria, Jesús Martín, Kristin F. Degnes, Håvard Sletta, Fernando Reyes, Sergey B. Zotchev

Publikováno v: Molecules, Vol 21, Iss 9, p 1131 (2016)

Activation of silent biosynthetic gene clusters in Streptomyces bacteria via overexpression of cluster-specific regulatory genes is a promising strategy for the discovery of novel bioactive secondary metabolites. This approach was used in an attempt

Externí odkaz: https://doaj.org/article/d6f73465ac2d4d049e469a280e821d48

An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts

Autor: Jimmy Mevaere, Olha Schneider, Haiyan Ma, Carlos Afonso, Sylvie Rebuffat, Christophe Goulard, Yanyan Li, Séverine Zirah, Olga N. Sekurova, Sergey B. Zotchev

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.8232. ⟨10.1038/s41598-018-26620-0⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Lasso peptides are ribosomally synthesized and post-translationally modified peptides produced by bacteria. They are characterized by an unusual lariat-knot structure. Targeted genome scanning revealed a wide diversity of lasso peptides encoded in ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ceb3352babe14e0acba7150c07c946
http://europepmc.org/articles/PMC5974421