Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Olga Mucha"'
Autor:
Natalia Pydyn, Anna Ferenc, Katarzyna Trzos, Ewelina Pospiech, Mateusz Wilamowski, Olga Mucha, Piotr Major, Justyna Kadluczka, Pedro M. Rodrigues, Jesus M. Banales, Jose M. Herranz, Matias A. Avila, Tomasz Hutsch, Piotr Malczak, Dorota Radkowiak, Andrzej Budzynski, Jolanta Jura, Jerzy Kotlinowski
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 887-906 (2024)
Background & Aims: Hepatic fibrosis is characterized by enhanced deposition of extracellular matrix (ECM), which results from the wound healing response to chronic, repeated injury of any etiology. Upon injury, hepatic stellate cells (HSCs) activate
Externí odkaz:
https://doaj.org/article/a8639a414f0d4d65bfedfeb983af94c3
Autor:
Olga Mucha, Paulina Podkalicka, Monika Żukowska, Ewelina Pośpiech, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Skeletal muscle regeneration relies on the reciprocal interaction between many types of cells. Regenerative capacity may be altered in different disorders. In our study, we investigated whether the deletion of miR-378a (miR-378) affects musc
Externí odkaz:
https://doaj.org/article/bb84564b4ad84804a5000fbf158dda0d
Autor:
Paulina Podkalicka, Olga Mucha, Katarzyna Kaziród, Krzysztof Szade, Jacek Stępniewski, Liudmyla Ivanishchuk, Hirofumi Hirao, Ewelina Pośpiech, Alicja Józkowicz, Jerzy W. Kupiec-Weglinski, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the alterations to systemic metabolism manifested in DMD patients contribute to the severe phenotype of this fatal disorder. We propose that microRNA-378a (miR-378)
Externí odkaz:
https://doaj.org/article/31f8767de0804f9ea3cdfb34755154d9
Autor:
Olga Mucha, Małgorzata Myszka, Paulina Podkalicka, Bianka Świderska, Agata Malinowska, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1648 (2023)
Mdx mice with a spontaneous mutation in exon 23 of the Dmd gene represent the most common model to investigate the pathophysiology of Duchenne muscular dystrophy (DMD). The disease, caused by the lack of functional dystrophin, is characterized by irr
Externí odkaz:
https://doaj.org/article/b5a527238d524efe87466f14c2ea7a38
Autor:
Olga Mucha, Paulina Podkalicka, Katarzyna Kaziród, Emilia Samborowska, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Background Duchenne muscular dystrophy (DMD) is an incurable disease, caused by the mutations in the DMD gene, encoding dystrophin, an actin-binding cytoskeletal protein. Lack of functional dystrophin results in muscle weakness, degeneration
Externí odkaz:
https://doaj.org/article/60466cde0c564a7bb16d8020398b93f5
Autor:
Iwona Bronisz-Budzyńska, Katarzyna Chwalenia, Olga Mucha, Paulina Podkalicka, Karolina-Bukowska-Strakova, Alicja Józkowicz, Agnieszka Łoboda, Magdalena Kozakowska, Józef Dulak
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract Duchenne muscular dystrophy (DMD) is a genetic disease evoked by a mutation in the dystrophin gene. It is associated with progressive muscle degeneration and increased inflammation. Up to this date, mainly anti-inflammatory treatment is avai
Externí odkaz:
https://doaj.org/article/175c5c5bbe5442d28ac094fd7588e154
Autor:
Olga Mucha, Katarzyna Kaziród, Paulina Podkalicka, Kinga Rusin, Józef Dulak, Agnieszka Łoboda
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 470 (2021)
Dysregulation of autophagy may contribute to the progression of various muscle diseases, including Duchenne muscular dystrophy (DMD). Heme oxygenase-1 (HO-1, encoded by Hmox1), a heme-degrading enzyme, may alleviate symptoms of DMD, inter alia, throu
Externí odkaz:
https://doaj.org/article/89f848ba6b4d4c1e811f4e40656ca3b0
Autor:
Paulina Podkalicka, Olga Mucha, Katarzyna Kaziród, Iwona Bronisz-Budzyńska, Sophie Ostrowska-Paton, Mateusz Tomczyk, Kalina Andrysiak, Jacek Stępniewski, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 481 (2021)
Duchenne muscular dystrophy (DMD), caused by a lack of functional dystrophin, is characterized by progressive muscle degeneration. Interestingly, dystrophin is also expressed in endothelial cells (ECs), and insufficient angiogenesis has already been
Externí odkaz:
https://doaj.org/article/3c0bb1db19374aebb98eca93a846744d
Autor:
Mateusz Jeż, Alicja Martyniak, Kalina Andrysiak, Olga Mucha, Krzysztof Szade, Alan Kania, Łukasz Chrobok, Katarzyna Palus-Chramiec, Anna M. Sanetra, Marian H. Lewandowski, Ewelina Pośpiech, Jacek Stępniewski, Józef Dulak
Publikováno v:
Cells, Vol 10, Iss 3, p 522 (2021)
Heme oxygenase-1 (HO-1, encoded by HMOX1) is a cytoprotective enzyme degrading heme into CO, Fe2+, and biliverdin. HO-1 was demonstrated to affect cardiac differentiation of murine pluripotent stem cells (PSCs), regulate the metabolism of murine adul
Externí odkaz:
https://doaj.org/article/c6f175a152ef436881f837a7de6be858
Autor:
Paulina Podkalicka, Jacek Stępniewski, Olga Mucha, Neli Kachamakova-Trojanowska, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1614 (2020)
Inadequate supply of oxygen (O2) is a hallmark of many diseases, in particular those related to the cardiovascular system. On the other hand, tissue hypoxia is an important factor regulating (normal) embryogenesis and differentiation of stem cells at
Externí odkaz:
https://doaj.org/article/ef3d8757781343fe85b9400e5160c218