A plasmatic score using a miRNA signature and CXCL-10 for accurate prediction and diagnosis of liver allograft rejection

Autor: Olga Millán, Pablo Ruiz, Judit Julian, Ana Lizana, Yiliam Fundora, Gonzalo Crespo, Jordi Colmenero, Miquel Navasa, Mercè Brunet

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionThe use of noninvasive biomarkers may avoid the need for liver biopsy (LB) and could guide immunosuppression adjustment in liver transplantation (LT). The aims of this study were: to confirm the predictive and diagnostic capacity of plasm

Externí odkaz: https://doaj.org/article/af6700a1eae642808d0bd4199c0be5f0

Monitoring of miR-181a-5p and miR-155-5p Plasmatic Expression as Prognostic Biomarkers for Acute and Subclinical Rejection in de novo Adult Liver Transplant Recipients

Autor: Olga Millán, Pablo Ruiz, Lara Orts, Paula Ferré, Gonzalo Crespo, Miguel Santana, Virginia Fortuna, Luís Quintairos, Miguel Navasa, Mercè Brunet

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Background and Aims: News strategies for the accurate assessment of the state of immunosuppression (IS) in liver transplant recipients are needed to prevent rejection and minimize drug-related side effects. miRNAs can potentially be used as diagnosti

Externí odkaz: https://doaj.org/article/94296114362f4d1a89b19cb95da6c010

Oncolytic adenoviruses armed with thymidine kinase can be traced by PET imaging and show potent antitumoural effects by ganciclovir dosing.

Autor: Daniel Abate-Daga, Nuria Andreu, Juan Camacho-Sánchez, Ramon Alemany, Raúl Herance, Olga Millán, Cristina Fillat

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26142 (2011)

Replication-competent adenoviruses armed with thymidine kinase (TK) combine the concepts of virotherapy and suicide gene therapy. Moreover TK-activity can be detected by noninvasive positron emission-computed tomography (PET) imaging, what could pote

Externí odkaz: https://doaj.org/article/604af4c77a974b9c9c06d99963ed66ff

Getting immunosuppression just right: the role of clinical biomarkers in predicting patient response post solid organ transplantation

Autor: Olga Millán, Mercè Brunet

Publikováno v: Expert review of clinical pharmacology. 14(12)

INTRODUCTION Actually, immunosuppression selection isn't based on individual immune alloreactivity, and immunosuppressive drug dosing is mainly based on the development of toxicity and the achievement of specific target concentrations. Since a succes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75c3b11ee9d8de4b0a99ff559032c0a
https://pubmed.ncbi.nlm.nih.gov/35734804

Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients

Autor: Klemens Budde, Mercè Brunet, Cristina Espinosa, Yolanda López-Púa, Ana Lizana, Luis Quintairos, Olga Millán, Virginia Fortuna, Claudia Sommerer, Lluis Guirado, Helena Colom

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
PLoS ONE, Vol 16, Iss 1, p e0245880 (2021)
PLoS ONE

Altres ajuts: TEVA Pharmaceuticals (EudraCT number: 2013-001817-33); Mutua Madrileña (AP153362014). Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95c3ce8aac0e107496a691f101cdd86
http://hdl.handle.net/2445/175587