Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Olga Mayans"'
Autor:
Rebekka Lambrecht, M. Eugenia Delgado, Vincent Gloe, Karina Schuetz, Anna Pia Plazzo, Barbara Franke, Truong San Phan, Jennifer Fleming, Olga Mayans, Thomas Brunner
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113513- (2023)
Summary: The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote apoptosis resistance in various tissues and disease contexts; however, its role in liver cell death remains unexplored. Hepatocyte-specific deletion of LRH-1 cau
Externí odkaz:
https://doaj.org/article/9d1b85502e4749a7bafdf95a2fd04723
Autor:
Malte Sinn, Marco Stanoppi, Franziskus Hauth, Jennifer R. Fleming, Dietmar Funck, Olga Mayans, Jörg S. Hartig
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Guanidino acids such as taurocyamine, guanidinobutyrate, guanidinopropionate, and guanidinoacetate have been detected in humans. However, except for guanidionacetate, which is a precursor of creatine, their metabolism and potential functions
Externí odkaz:
https://doaj.org/article/c4b15171376e437b98da166213969df1
Autor:
Thomas Zacharchenko, Till Dorendorf, Nicolas Locker, Evert Van Dijk, Anja Katzemich, Kay Diederichs, Belinda Bullard, Olga Mayans
Publikováno v:
Open Biology, Vol 13, Iss 4 (2023)
Obscurins are large filamentous proteins with crucial roles in the assembly, stability and regulation of muscle. Characteristic of these proteins is a tandem of two C-terminal kinase domains, PK1 and PK2, that are separated by a long intrinsically di
Externí odkaz:
https://doaj.org/article/7c1bd945c36547c1af49473a13231fe1
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5409-5419 (2022)
Sequence comparison is critical for the functional assignment of newly identified protein genes. As uncharacterized protein sequences accumulate, there is an increasing need for sensitive tools for their classification. Here, we present a novel multi
Externí odkaz:
https://doaj.org/article/ee9f6d605da94a7fb66bc9d8cd0bdb8b
Autor:
Christos Stergiou, Rhys Williams, Jennifer R. Fleming, Vasiliki Zouvelou, Elpinickie Ninou, Francesca Andreetta, Elena Rinaldi, Ornella Simoncini, Renato Mantegazza, Julius Bogomolovas, John Tzartos, Siegfried Labeit, Olga Mayans, Socrates Tzartos
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 449 (2023)
Myasthenia gravis (MG) is an autoimmune disease caused by antibodies targeting the neuromuscular junction (NJ) of skeletal muscles. The major MG autoantigen is nicotinic acetylcholine receptor. Other autoantigens at the NJ include MuSK, LRP4 and agri
Externí odkaz:
https://doaj.org/article/186ab3b480f74a108ef07beaa5b2468e
Autor:
Daniel Porto, Yohei Matsunaga, Barbara Franke, Rhys M Williams, Hiroshi Qadota, Olga Mayans, Guy M Benian, Hang Lu
Publikováno v:
eLife, Vol 10 (2021)
The force-induced unfolding and refolding of proteins is speculated to be a key mechanism in the sensing and transduction of mechanical signals in the living cell. Yet, little evidence has been gathered for its existence in vivo. Prominently, stretch
Externí odkaz:
https://doaj.org/article/3cbb59f548534da7ac17b2502b6e4447
Autor:
Sebastian Knorr, Malte Sinn, Dmitry Galetskiy, Rhys M. Williams, Changhao Wang, Nicolai Müller, Olga Mayans, David Schleheck, Jörg S. Hartig
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Lysine degradation and the role of the metabolites glutarate and L-2-hydroxyglutarate have remained elusive in many organisms including Escherichia coli. Here authors present a pathway for catabolism of lysine to succinate in E. coli involving glutar
Externí odkaz:
https://doaj.org/article/e4e3b0c443c147f993908177af49c611
Autor:
Thomas Lanzicher, Tiankun Zhou, Chandra Saripalli, Vic Keschrumrus, John E. Smith III, Olga Mayans, Orfeo Sbaizero, Henk Granzier
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Titin is a large filamentous protein that forms a sarcomeric myofilament with a molecular spring region that develops force in stretched sarcomeres. The molecular spring has a complex make-up that includes the N2A element. This element largely consis
Externí odkaz:
https://doaj.org/article/4b14674ac8e34676a1fa21d9d3f71407
Autor:
Felix Simkovic, Jens M. H. Thomas, Ronan M. Keegan, Martyn D. Winn, Olga Mayans, Daniel J. Rigden
Publikováno v:
IUCrJ, Vol 3, Iss 4, Pp 259-270 (2016)
For many protein families, the deluge of new sequence information together with new statistical protocols now allow the accurate prediction of contacting residues from sequence information alone. This offers the possibility of more accurate ab initio
Externí odkaz:
https://doaj.org/article/3caa52adb6874381ad5968a460132805
Autor:
Jens M. H. Thomas, Ronan M. Keegan, Jaclyn Bibby, Martyn D. Winn, Olga Mayans, Daniel J. Rigden
Publikováno v:
IUCrJ, Vol 2, Iss 2, Pp 198-206 (2015)
Coiled-coil protein folds are among the most abundant in nature. These folds consist of long wound α-helices and are architecturally simple, but paradoxically their crystallographic structures are notoriously difficult to solve with molecular-replac
Externí odkaz:
https://doaj.org/article/96960e5de316451abc37a27e314fe139