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Reversed BCR/ABL rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia
Autor:
Orly Yehuda, Svetlana Krichevsky, Marion Werner, Dvorah Abeliovich, Susana Ben-Neriah, Olga Ludkovsky, Dina Ben-Yehuda, Arnon Nagler
Publikováno v:
Cancer Genetics and Cytogenetics. 81:115-117
We investigated leukemic cells from a patient with chronic myelocytic leukemia (CML) and a normal 46,XX karyotype. Molecular studies revealed rearrangement of the M-bcr region and formation of BCR/ABL fusion mRNA with b3a2 configuration. Fluorescence