Výsledky vyhledávání - "Olga Lorena German"

Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons

Autor: Nora P. Rotstein, Tamara Soto, German Ariel Michelis, S. Patricia Becerra, Luis E. Politi, Rafael Villasmil, Olga Lorena German

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
J Neurochem

Pigment epithelium-derived factor (PEDF) is a cytoprotective protein for the retina. We hypothesize that this protein acts on neuronal survival and differentiation of photoreceptor cells in culture. The purpose of the present study was to evaluate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a58fe127e6ee4fa945fe9cd7b5e14f
Wiley Online Library

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Retina stem cells, hopes and obstacles

Autor: Luis E. Politi, Harmonie Vallese-Maurizi, Tamara Soto, Olga Lorena German, Nora P. Rotstein

Publikováno v: World Journal of Stem Cells
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Retinal degeneration is a major contributor to visual dysfunction worldwide. Although it comprises several eye diseases, loss of retinal pigment epithelial (RPE) and photoreceptor cells are the major contributors to their pathogenesis. Early therapie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1461afbbfca1f4c95b5d8fe315c62d4
https://pubmed.ncbi.nlm.nih.gov/34786153

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Retinoid X receptor activation promotes photoreceptor survival and modulates the inflammatory response in a mouse model of retinitis pigmentosa

Autor: Yanel A. Volonté, Victoria B. Ayala-Peña, Nora P. Rotstein, Olga Lorena German, Harmonie Vallese-Maurizi, Luis E. Politi, Andres Garelli

Publikováno v: Biochimica et biophysica acta. Molecular cell research. 1868(11)

Photoreceptor cell (PHR) death is a hallmark of most retinal neurodegenerative diseases, in which inflammation plays a critical role. Activation of retinoid X receptors (RXR) modulates and integrates multiple cell functions, and has beneficial effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb34d4aeb77f357bbdffceaa6122277
https://pubmed.ncbi.nlm.nih.gov/34271041

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PEDF and Derived Peptides Prevent Apoptosis and Promote Differentiation of Retinal Photoreceptors

Autor: Germán Michelis, Luis E. Politi, Rafael Villasmil, Nora P. Rotstein, Olga Lorena German, S. Patricia Becerra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcc9b87ca054635d968aa91d7be772cc
https://doi.org/10.1101/2021.01.01.425044

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Light, lipids and photoreceptor survival: live or let die?

Autor: Olga Lorena German, Nora P. Rotstein, Daniela L. Agnolazza, Luis E. Politi

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Due to its constant exposure to light and its high oxygen consumption the retina is highly sensitive to oxidative damage, which is a common factor in inducing the death of photoreceptors after light damage or in retina inherited degenerations. The hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200fe43c6c54b53429bb096cd8dc8dcc
https://doi.org/10.1039/c5pp00194c

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Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress

Autor: Maria V. Simon, Martin-Paul Agbaga, Luis Enrique Politi, Nora P. Rotstein, Daniela L. Agnolazza, Olga Lorena German, Andres Garelli, Robert E. Anderson

Oxidative stress is involved in activating photoreceptor death in several retinal degenerations. Docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, protects cultured retina photoreceptors from apoptosis induced by oxidati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b4e9b79798e3520edf2a7060664289
https://europepmc.org/articles/PMC4755815/

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Protective effects of retinoid x receptors on retina pigment epithelium cells

Autor: Victoria B. Ayala-Peña, Luis E. Politi, Olga Lorena German, Nora P. Rotstein, Fiorella Pilotti, Yanel A. Volonté

Publikováno v: Biochimica et biophysica acta. 1863(6 Pt)

Age-related macular degeneration (AMD) is among the main pathologies leading to blindness in adults and has currently no cure or effective treatment. Selective apoptosis of retina pigment epithelial (RPE) cells results in the progressive loss of phot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00036e1b3a1c18696629d1a823d4f436
https://pubmed.ncbi.nlm.nih.gov/26883505

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Retinoid X Receptors Activation is Essential for Docosahexanoic Acid Protection of Retina Photoreceptors

Autor: Luis E. Politi, Olga Lorena German, Daniela L. Agnolazza, Sandra Monaco, Nora P. Rotstein

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of Lipid Research, Vol 54, Iss 8, Pp 2236-2246 (2013)

We have established that docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, promotes survival of rat retina photoreceptors during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359e978162f2cdcd8442189910ce2def
http://www.jlr.org

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Retinal pigment epithelial cells promote spatial reorganization and differentiation of retina photoreceptors

Autor: Edgardo Buzzi, Nora P. Rotstein, Luis E. Politi, Enrique Rodriguez-Boulan, Olga Lorena German

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Retina differentiation involves the acquisition of a precise layered arrangement, with RPE cells in the first layer in intimate contact with photoreceptors in the second layer. Here, we developed an in vitro coculture model, to test the hypothesis th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20de0a478ca6fcc6dce68eaad1341e39
Wiley Online Library

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Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway

Autor: Olga Lorena German, María Fernanda Insua, Claudia Gentili, Luis E. Politi, Nora P. Rotstein

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. Docosahexaenoic acid (DHA), the major retinal polyunsaturated fatty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98309dc805279056792ece32547d3441
https://pubmed.ncbi.nlm.nih.gov/16923163

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