Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Olga Lancho"'
Autor:
Daniel Herranz, Hossein Khiabanian, Xiaoyang Su, Pedro P. Rocha, Zhenyu Zuo, Eric Chiles, Haiyan Zheng, Caifeng Zhao, Shirley Luo, Patricia Renck Nunes, Luca Tottone, Jesminara Khatun, Maya Aleksandrova, Victoria da Silva-Diz, Amartya Singh, Olga Lancho
T-cell acute lymphoblastic leukemia (T-ALL) is a NOTCH1-driven disease in need of novel therapies. Here, we identify a NOTCH1–SIRT1–KAT7 link as a therapeutic vulnerability in T-ALL, in which the histone deacetylase SIRT1 is overexpressed downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b138f3c30ed860fed6fefc995070081d
https://doi.org/10.1158/2643-3230.c.6551054
https://doi.org/10.1158/2643-3230.c.6551054
Autor:
Daniel Herranz, Hossein Khiabanian, Xiaoyang Su, Pedro P. Rocha, Zhenyu Zuo, Eric Chiles, Haiyan Zheng, Caifeng Zhao, Shirley Luo, Patricia Renck Nunes, Luca Tottone, Jesminara Khatun, Maya Aleksandrova, Victoria da Silva-Diz, Amartya Singh, Olga Lancho
GSEA analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4797daa36a6079f88c8fd29da79b6f9b
https://doi.org/10.1158/2643-3230.22545920.v1
https://doi.org/10.1158/2643-3230.22545920.v1
Autor:
Daniel Herranz, Hossein Khiabanian, Xiaoyang Su, Pedro P. Rocha, Zhenyu Zuo, Eric Chiles, Haiyan Zheng, Caifeng Zhao, Shirley Luo, Patricia Renck Nunes, Luca Tottone, Jesminara Khatun, Maya Aleksandrova, Victoria da Silva-Diz, Amartya Singh, Olga Lancho
Gene expression profiling results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ac7750cef879644be152e5b0ba8d9
https://doi.org/10.1158/2643-3230.22545923.v1
https://doi.org/10.1158/2643-3230.22545923.v1
Autor:
Daniel Herranz, Pedro P. Rocha, Hossein Khiabanian, Charles G. Mullighan, Pieter Van Vlierberghe, Tom Taghon, Jean Soulier, Jules P.P. Meijerink, Manel Esteller, Rico Hagelaar, Carlos A. García-Prieto, Stéphanie Gachet, Shirley Luo, Victoria da Silva-Diz, Matthew A. Lawlor, Steven Strubbe, Anna Kuchmiy, Juliette Roels, Shunsuke Kimura, Amartya Singh, Jui-Wan Loh, Olga Lancho, Luca Tottone
Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the pathogenesis of various cancers, including T-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13df8baed6810ec8bd74e0221014e950
https://doi.org/10.1158/2643-3230.c.6550069.v1
https://doi.org/10.1158/2643-3230.c.6550069.v1
Autor:
Daniel Herranz, Hossein Khiabanian, Xiaoyang Su, Pedro P. Rocha, Zhenyu Zuo, Eric Chiles, Haiyan Zheng, Caifeng Zhao, Shirley Luo, Patricia Renck Nunes, Luca Tottone, Jesminara Khatun, Maya Aleksandrova, Victoria da Silva-Diz, Amartya Singh, Olga Lancho
H4K12ac ChIPseq results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bcf53115ce935b28e9b530437e136c
https://doi.org/10.1158/2643-3230.22545917.v1
https://doi.org/10.1158/2643-3230.22545917.v1
Autor:
Daniel Herranz, Pedro P. Rocha, Hossein Khiabanian, Charles G. Mullighan, Pieter Van Vlierberghe, Tom Taghon, Jean Soulier, Jules P.P. Meijerink, Manel Esteller, Rico Hagelaar, Carlos A. García-Prieto, Stéphanie Gachet, Shirley Luo, Victoria da Silva-Diz, Matthew A. Lawlor, Steven Strubbe, Anna Kuchmiy, Juliette Roels, Shunsuke Kimura, Amartya Singh, Jui-Wan Loh, Olga Lancho, Luca Tottone
Supplementary Figures and Tables combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764d668dfe144b8af981225fe96e1136
https://doi.org/10.1158/2643-3230.22542880
https://doi.org/10.1158/2643-3230.22542880
Autor:
Daniel Herranz, Hossein Khiabanian, Xiaoyang Su, Pedro P. Rocha, Zhenyu Zuo, Eric Chiles, Haiyan Zheng, Caifeng Zhao, Shirley Luo, Patricia Renck Nunes, Luca Tottone, Jesminara Khatun, Maya Aleksandrova, Victoria da Silva-Diz, Amartya Singh, Olga Lancho
Acetyl-proteomic results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a6b05b045aae8828b07fea75949827
https://doi.org/10.1158/2643-3230.22545926.v1
https://doi.org/10.1158/2643-3230.22545926.v1
Autor:
Victoria da Silva-Diz, Amartya Singh, Olga Lancho, Maya Aleksandrova, Komal Mandleywala, Patricia Renck Nunes, Jesminara Khatun, Oekyung Kim, Eric Chiles, Xiaoyang Su, Hossein Khiabanian, Kathryn E. Wellen, Daniel Herranz
Publikováno v:
bioRxiv
T-cell Acute Lymphoblastic Leukemia (T-ALL) is a hematological malignancy in need of novel therapeutic approaches. Here, we identify the ATP-citrate lyase ACLY as a novel therapeutic target in T-ALL. Our results show that ACLY is overexpressed in T-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ed518a84af5d86703d12afe93dddab
https://europepmc.org/articles/PMC10081278/
https://europepmc.org/articles/PMC10081278/
Autor:
Olga Lancho, Amartya Singh, Victoria da Silva-Diz, Maya Aleksandrova, Jesminara Khatun, Luca Tottone, Patricia Renck Nunes, Shirley Luo, Caifeng Zhao, Haiyan Zheng, Eric Chiles, Zhenyu Zuo, Pedro P. Rocha, Xiaoyang Su, Hossein Khiabanian, Daniel Herranz
Publikováno v:
Blood Cancer Discov
T-cell acute lymphoblastic leukemia (T-ALL) is a NOTCH1-driven disease in need of novel therapies. Here, we identify a NOTCH1–SIRT1–KAT7 link as a therapeutic vulnerability in T-ALL, in which the histone deacetylase SIRT1 is overexpressed downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939b6b85f53481ca8ab1df6a2160907f
https://doi.org/10.1101/2022.05.21.492944
https://doi.org/10.1101/2022.05.21.492944
Autor:
Daniel Herranz, Olga Lancho
Publikováno v:
Trends in Cancer. 4:810-822
MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50–60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1df67f601d4e8168bfff5bc9399f882
https://doi.org/10.1016/j.trecan.2018.10.003
https://doi.org/10.1016/j.trecan.2018.10.003
