Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Olga Labudova"'
Publikováno v:
Neonatology. 81:266-278
No information is available on transcription factors (TF), the main regulators of gene expression, in perinatal asphyxia (PA), and as pathomechanisms in PA are different, data on TFs from ischemia or hypoxia cannot be simply extrapolated to PA, and n
Autor:
Gert Lubec, Joe Craft, Nigel J. Cairns, G J M Pruijn, Bettina Bidmon, Tilmann Achsel, Kurt Krapfenbauer, Dritan Turhani-Schatzmann, Olga Labudova, Elisabet Welin Henriksson, Rainer Seidl
Publikováno v:
ELECTROPHORESIS. 22:43-48
The small nuclear ribonucleoprotein 70K (snRNP 70K; U1-70 kDa) is an integral part of the spliceosome, a large RNA-protein complex catalyzing the removal of introns from nuclear pre-mRNA. snRNP is one of the best-studied essential subunits of snRNPs,
Publikováno v:
Clinical Science. 96:279-285
Impaired glucose metabolism in Down's syndrome (DS) has been well-documented in vivo, although information on the underlying biochemical defect is limited and no biochemical studies on glucose handling enzymes have been carried out in the brain. Thro
Autor:
Nigel J. Cairns, Olga Labudova, Gert Lubec, Susanne Fang-Kircher, Erwin Kitzmueller, Hermann Rink
Publikováno v:
Life Sciences. 64:1689-1699
Although deficient DNA-repair was proposed for neurodegenerative disorders including Down Syndrome (DS), repair genes for nucleotide excision repair or X-ray repair have not been studied in brain yet. As one of the hypotheses for the pathogenesis of
Autor:
Erwin Kitzmüller, Heike Moenkemann, Gert Lubec, Kurt Krapfenbauer, Olga Labudova, Nigel J. Cairns, Hermann Rink
Publikováno v:
Neuroscience Letters. 252:159-162
JunD is a member of the Jun family of transcription factors (TF), recently shown to negatively regulate cell growth and antagonizes transformation by the protooncogene ras: c-jun decreases while junD is accumulating when fibroblasts become quiescent.
Autor:
Erwin Kitzmüller, Barbara Lubec, Wilhelm Mosgoeller, Gerhard Fuerst, Mario Herrera-Marschitz, Olga Labudova, Harald Hoeger
Publikováno v:
Life Sciences. 62:275-282
RNA polymerases transcribe nuclear genes for ribosomal RNA thus representing ribosomal biogenesis. RNA polymerase I transcribes class I genes, coding for large ribosomal RNA and is located in the nucleolus. RNA polymerase III transcribes class III ge
Publikováno v:
Life Sciences. 61:2417-2423
The XRCC1 gene was described to play a role for the sensitivity of mammalian cell lines towards ionizing irradiation. Cells with a mutation of this gene present with decreased single strand break repair, reduced recombination repair, show increased d
Publikováno v:
Free Radical Research. 26:463-468
The radiation protective effect of thioredoxin (TRX) in a bacterial system has been reported and based upon this observation we were interested to examine TRX transcription in the mammalian system following ionizing irradiation. In order to answer th
Autor:
Harald Hoeger, Barbara Lubec, Wilhelm Mosgoeller, Manfred Marx, Susanne Fang-Kircher, Adolf Muehl, J. Gialamas, Olga Labudova
Publikováno v:
Circulation. 94:2620-2625
Background Hyperhomocyst(e)inemia is strongly associated with occlusive arterial disease. A direct effect of homocysteine on the proliferation of smooth muscle cells was proposed recently. This observation led us to examine the effect of homocysteine
Autor:
Harald Hoeger, Philomena Kastner, Olga Labudova, Susanne Fang-Kircher, Wilhelm Mosgoeller, Gert Lubec, Peter Seither, Erwin Kitzmueller, Barbara Lubec
Publikováno v:
Experimental neurology. 161(1)
Ribosomes are integral constitutens of the protein synthesis machinery. Polymerase I (POL I) is located in the nucleolus and transcribes the large ribosomal genes. POL I activity is decreased in ischemia but nothing is known so far on POL I in perina