Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Olga L. Rojas"'
Autor:
Mohamed Reda Fazazi, Prenitha Mercy Ignatius Arokia Doss, Resel Pereira, Neva Fudge, Aryan Regmi, Charles Joly-Beauparlant, Irshad Akbar, Asmita Pradeep Yeola, Benoit Mailhot, Joanie Baillargeon, Philippe Grenier, Nicolas Bertrand, Steve Lacroix, Arnaud Droit, Craig S. Moore, Olga L. Rojas, Manu Rangachari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH[MOG] mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG). Here, we show that upon immunization with the T cell-obligate a
Externí odkaz:
https://doaj.org/article/03e8ecf578cd4ef3913cc229d2858241
Autor:
Elissa G. Currie, Bryan Coburn, Elisa A. Porfilio, Ping Lam, Olga L. Rojas, Jan Novak, Stuart Yang, Raad B. Chowdhury, Lesley A. Ward, Pauline W. Wang, Khashayar Khaleghi, James An, Sarah Q. Crome, Michelle A. Hladunewich, Sean J. Barbour, Daniel C. Cattran, Rulan S. Parekh, Christoph Licht, Rohan John, Rupert Kaul, Kenneth Croitoru, Scott D. Gray-Owen, David S. Guttman, Jennifer L. Gommerman, Heather N. Reich
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
IgA nephropathy (IgAN) is a leading cause of kidney failure, yet little is known about the immunopathogenesis of this disease. IgAN is characterized by deposition of IgA in the kidney glomeruli, but the source and stimulus for IgA production are not
Externí odkaz:
https://doaj.org/article/594e642df71840fcba72985a2ef82850
Autor:
Valeria Ramaglia, Salma Sheikh-Mohamed, Karen Legg, Calvin Park, Olga L Rojas, Stephanie Zandee, Fred Fu, Olga Ornatsky, Eric C Swanson, David Pitt, Alexandre Prat, Trevor D McKee, Jennifer L Gommerman
Publikováno v:
eLife, Vol 8 (2019)
Multiple sclerosis (MS) is characterized by demyelinated and inflammatory lesions in the brain and spinal cord that are highly variable in terms of cellular content. Here, we used imaging mass cytometry (IMC) to enable the simultaneous imaging of 15+
Externí odkaz:
https://doaj.org/article/6def8078950146e587285cba613947c2
Autor:
Chukwuma C. Okafor, Olga L. Rojas, Bujing Liu, Kelly Turner, J. Brian Anderson, James S. Davidson
Publikováno v:
Journal of Performance of Constructed Facilities. 37
Autor:
Valeria Ramaglia, Jennifer Y. Yam, Camille Grasmuck, Dennis S. W. Lee, Laure Michel, Lyne Bourbonnière, Lesley A. Ward, Amit Bar-Or, Alexandre Prat, Dragos Dasoveanu, Jennifer L. Gommerman, Olga L. Rojas, Stephanie Zandee
Publikováno v:
The Journal of Immunology. 207:1513-1521
B cells have been implicated in the pathogenesis of multiple sclerosis, but the mechanisms that guide B cell activation in the periphery and subsequent migration to the CNS remain incompletely understood. We previously showed that systemic inflammati
Publikováno v:
Nature Reviews. Drug Discovery
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather active participants in autoimmune aetiology. This has been fuelled in part by the clinical success of B cell depletion therapies (BCDTs). Originally conceived
Publikováno v:
Immunological Reviews. 299:45-60
The remarkable success of anti-CD20 B cell depletion therapies in reducing the burden of multiple sclerosis (MS) disease has prompted significant interest in how B cells contribute to neuroinflammation. Most focus has been on identifying pathogenic C
Autor:
John G. Sled, Jennifer L. Gommerman, Shannon E. Dunn, Olga L. Rojas, Melika Pahlevan Sabbagh, Stefanie Kuerten, Josephine Gomes, Marina Moshkova, Tae Joon Yi, Heather Whetstone, Fei Linda Zhao, Valeria Ramaglia, Laura Woo, Monan Angela Zhang, Lindsay S. Cahill, Thomas S Przybycien
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22710-22720
Experimental autoimmune encephalomyelitis (EAE) is the most common model of multiple sclerosis (MS). This model has been instrumental in understanding the events that lead to the initiation of central nervous system (CNS) autoimmunity. Though EAE has
Autor:
Salma Sheikh-Mohamed, Baweleta Isho, Gary Y.C. Chao, Michelle Zuo, Carmit Cohen, Yaniv Lustig, George R. Nahass, Rachel E. Salomon-Shulman, Grace Blacker, Mahya Fazel-Zarandi, Bhavisha Rathod, Karen Colwill, Alainna Jamal, Zhijie Li, Keelia Quin de Launay, Alyson Takaoka, Julia Garnham-Takaoka, Anjali Patel, Christine Fahim, Aimee Paterson, Angel Xinliu Li, Nazrana Haq, Shiva Barati, Lois Gilbert, Karen Green, Mohammad Mozafarihashjin, Philip Samaan, Patrick Budylowski, Walter L. Siqueira, Samira Mubareka, Mario Ostrowski, James M. Rini, Olga L. Rojas, Irving L. Weissman, Michal Caspi Tal, Allison McGeer, Gili Regev-Yochay, Sharon Straus, Anne-Claude Gingras, Jennifer L. Gommerman
Publikováno v:
The Journal of Immunology. 208:59.14-59.14
SARS-CoV-2 is a novel respiratory virus that has quickly spread across the globe. The virus uses a protein called Spike and its associated receptor binding domain (RBD) to interact with angiotensin converting enzyme-2 (ACE-2) on the surface of epithe
Publikováno v:
Annual review of immunology. 39
Multiple sclerosis (MS) is a chronic disease that is characterized by the inappropriate invasion of lymphocytes and monocytes into the central nervous system (CNS), where they orchestrate the demyelination of axons, leading to physical and cognitive