Výsledky vyhledávání - "Olga L. Miakotina"

Akademický článek

Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis

Autor: Florita C. Henderson, Olga L. Miakotina, Rama K. Mallampalli

Publikováno v: Journal of Lipid Research, Vol 47, Iss 10, Pp 2314-2324 (2006)

Pseudomonas aeruginosa causes sepsis-induced acute lung injury, a disorder associated with deficiency of surfactant phosphatidylcholine (PtdCho). P. aeruginosa (PA103) utilizes a type III secretion system (TTSS) to induce programmed cell death. Herei

Externí odkaz: https://doaj.org/article/e74a6179c0834dbf82b63d87928bed67

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Human Adenovirus Modulates Surfactant Phospholipid Trafficking

Autor: Rama K. Mallampalli, Diann M. McCoy, Lei Shi, Olga L. Miakotina, Dwight C. Look

Publikováno v: Traffic. 8:1765-1777

Surfactant, highly enriched with phosphatidylcholine (PC), is secreted into the airspace by a classic apical secretory route, thereby maintaining lung stability. Herein, we show that adenoviral infection decreases surfactant PC in lungs by inhibiting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09733bc1a5ce4fff04e23a27c0ce2192
https://doi.org/10.1111/j.1600-0854.2007.00641.x

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Pseudomonas aeruginosaand sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARα–RXR

Autor: Marianna Agassandian, Rama K. Mallampalli, Olga L. Miakotina, Matthew Andrews, Satya Mathur

Publikováno v: Biochemical Journal. 403:409-420

Bacterial infection triggers an acute inflammatory response that might alter phospholipid metabolism. We have investigated the acute-phase response of murine lung epithelia to Pseudomonas aeruginosa infection. Ps. aeruginosa triggered secretion of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7313a29dcea2f9dce0036134aeab62c9
https://doi.org/10.1042/bj20061364

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Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis

Autor: Olga L. Miakotina, Florita C. Henderson, Rama K. Mallampalli

Publikováno v: Journal of Lipid Research, Vol 47, Iss 10, Pp 2314-2324 (2006)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e1eb7370c203016dd60b8a512f757a
https://doi.org/10.1194/jlr.m600284-jlr200

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Signal transduction events involved in TPA downregulation of SP-A gene expression

Autor: Jeanne M. Snyder, Olga L. Miakotina

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L1210-L1219

Surfactant protein A (SP-A), the most abundant pulmonary surfactant protein, plays a role in innate host defense and blocks the inhibitory effects of serum proteins on surfactant surface tension-lowering properties. SP-A mRNA and protein are downregu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cf5e263513643baf60f5c8ab8693e1
https://doi.org/10.1152/ajplung.00416.2003

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TNF-α inhibits SP-A gene expression in lung epithelial cells via p38 MAPK

Autor: Jeanne M. Snyder, Olga L. Miakotina

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L418-L427

Surfactant protein A (SP-A), the major lung surfactant-associated protein, mediates local defense against pathogens and modulates inflammation in the alveolus. Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, inhibits SP-A gene expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d554377cb294502c34dca87bb518cc36
https://doi.org/10.1152/ajplung.00470.2001

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Mechanism of alltrans-retinoic acid and glucocorticoid regulation of surfactant protein mRNA

Autor: Kelli L. Goss, Olga L. Miakotina, Jeanne M. Snyder, Thomas N. George

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 274:L560-L566

The surfactant proteins (SPs) are required for the normal function of pulmonary surfactant, a lipoprotein substance that prevents alveolar collapse at end expiration. We characterized the effects of cortisol and all trans-retinoic acid (RA) on SP-A a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c72f8a636595894de4221e7c832303
https://doi.org/10.1152/ajplung.1998.274.4.l560

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Human Adenovirus Modulates Surfactant Phospholipid Trafficking

Autor: Rama K. Mallampalli, Olga L. Miakotina, Dwight C. Look

Publikováno v: The FASEB Journal. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8aeab68ad2796f739918193abbe721e
https://doi.org/10.1096/fasebj.20.4.a84-a

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Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2

Autor: Dwight C. Look, Marianna Agassandian, Olga L. Miakotina, Lei Shi, Rama K. Mallampalli

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 288(1)

We examined the effect of wild-type human adenovirus (Ad5) on choline transport in murine lung epithelia (MLE) and in rodent primary alveolar type II cells. Cells were active in pH-sensitive, reversible transport of choline, a process blocked pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c93bc153cf0f6921adee5930fa51cd
https://pubmed.ncbi.nlm.nih.gov/15377492

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