Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Olga L Rojas"'
Autor:
Valeria Ramaglia, Salma Sheikh-Mohamed, Karen Legg, Calvin Park, Olga L Rojas, Stephanie Zandee, Fred Fu, Olga Ornatsky, Eric C Swanson, David Pitt, Alexandre Prat, Trevor D McKee, Jennifer L Gommerman
Publikováno v:
eLife, Vol 8 (2019)
Multiple sclerosis (MS) is characterized by demyelinated and inflammatory lesions in the brain and spinal cord that are highly variable in terms of cellular content. Here, we used imaging mass cytometry (IMC) to enable the simultaneous imaging of 15+
Externí odkaz:
https://doaj.org/article/6def8078950146e587285cba613947c2
Autor:
Mohamed Reda Fazazi, Prenitha Mercy Ignatius Arokia Doss, Resel Pereira, Neva Fudge, Aryan Regmi, Charles Joly-Beauparlant, Irshad Akbar, Asmita Pradeep Yeola, Benoit Mailhot, Joanie Baillargeon, Philippe Grenier, Nicolas Bertrand, Steve Lacroix, Arnaud Droit, Craig S. Moore, Olga L. Rojas, Manu Rangachari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH[MOG] mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG). Here, we show that upon immunization with the T cell-obligate a
Externí odkaz:
https://doaj.org/article/03e8ecf578cd4ef3913cc229d2858241
Autor:
Taha Hirbod, Xiangrong Kong, Godgrey Kigozi, Anthony Ndyanabo, David Serwadda, Jessica L Prodger, Aaron A Tobian, Fred Nalugoda, Maria J Wawer, Kamnoosh Shahabi, Olga L Rojas, Jennifer L Gommerman, Kristina Broliden, Rupert Kaul, Ronald H Gray
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004416 (2014)
BackgroundThe foreskin is the site of most HIV acquisition in uncircumcised heterosexual men. Although HIV-exposed, seronegative (HESN) uncircumcised men demonstrate HIV-neutralizing IgA and increased antimicrobial peptides (AMPs) in the foreskin pre
Externí odkaz:
https://doaj.org/article/fb6f8a3c7bfe484f8348c03156744fad
Autor:
Daniel Herrera, Olga L Rojas, Carolina Duarte-Rey, Rubén D Mantilla, Juana Angel, Manuel A Franco
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97087 (2014)
The mechanisms that contribute to the maintenance of serological memory are still unclear. Rotavirus (RV) memory B cells (mBc) are enriched in IgM(+) and CD27- subpopulations, which are associated with autoimmune diseases pathogenesis. In patients wi
Externí odkaz:
https://doaj.org/article/e4b41506b1c04b83ba291e9677ac6e68
Autor:
Chukwuma C. Okafor, Olga L. Rojas, Bujing Liu, Kelly Turner, J. Brian Anderson, James S. Davidson
Publikováno v:
Journal of Performance of Constructed Facilities. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a375f3a2dfec9869d546b340b086b2c
https://doi.org/10.1061/jpcfev.cfeng-4136
https://doi.org/10.1061/jpcfev.cfeng-4136
Autor:
Valeria Ramaglia, Jennifer Y. Yam, Camille Grasmuck, Dennis S. W. Lee, Laure Michel, Lyne Bourbonnière, Lesley A. Ward, Amit Bar-Or, Alexandre Prat, Dragos Dasoveanu, Jennifer L. Gommerman, Olga L. Rojas, Stephanie Zandee
Publikováno v:
The Journal of Immunology. 207:1513-1521
B cells have been implicated in the pathogenesis of multiple sclerosis, but the mechanisms that guide B cell activation in the periphery and subsequent migration to the CNS remain incompletely understood. We previously showed that systemic inflammati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27deb72bf1d43d11a86ffde831c30220
https://doi.org/10.4049/jimmunol.2001413
https://doi.org/10.4049/jimmunol.2001413
Publikováno v:
Nature Reviews. Drug Discovery
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather active participants in autoimmune aetiology. This has been fuelled in part by the clinical success of B cell depletion therapies (BCDTs). Originally conceived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885dc27a2c38856e64941001c75a4a84
https://doi.org/10.1038/s41573-020-00092-2
https://doi.org/10.1038/s41573-020-00092-2
Publikováno v:
Immunological Reviews. 299:45-60
The remarkable success of anti-CD20 B cell depletion therapies in reducing the burden of multiple sclerosis (MS) disease has prompted significant interest in how B cells contribute to neuroinflammation. Most focus has been on identifying pathogenic C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db89442a3801f6271d6262a7824c1db6
https://doi.org/10.1111/imr.12929
https://doi.org/10.1111/imr.12929
Autor:
Elissa G. Currie, Bryan Coburn, Elisa A. Porfilio, Ping Lam, Olga L. Rojas, Jan Novak, Stuart Yang, Raad B. Chowdhury, Lesley A. Ward, Pauline W. Wang, Khashayar Khaleghi, James An, Sarah Q. Crome, Michelle A. Hladunewich, Sean J. Barbour, Daniel C. Cattran, Rulan S. Parekh, Christoph Licht, Rohan John, Rupert Kaul, Kenneth Croitoru, Scott D. Gray-Owen, David S. Guttman, Jennifer L. Gommerman, Heather N. Reich
Publikováno v:
JCI Insight. 7
IgA nephropathy (IgAN) is a leading cause of kidney failure, yet little is known about the immunopathogenesis of this disease. IgAN is characterized by deposition of IgA in the kidney glomeruli, but the source and stimulus for IgA production are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fc4d017764bce65f966766775faf01
https://doi.org/10.1172/jci.insight.141289
https://doi.org/10.1172/jci.insight.141289
Autor:
John G. Sled, Jennifer L. Gommerman, Shannon E. Dunn, Olga L. Rojas, Melika Pahlevan Sabbagh, Stefanie Kuerten, Josephine Gomes, Marina Moshkova, Tae Joon Yi, Heather Whetstone, Fei Linda Zhao, Valeria Ramaglia, Laura Woo, Monan Angela Zhang, Lindsay S. Cahill, Thomas S Przybycien
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22710-22720
Experimental autoimmune encephalomyelitis (EAE) is the most common model of multiple sclerosis (MS). This model has been instrumental in understanding the events that lead to the initiation of central nervous system (CNS) autoimmunity. Though EAE has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6711f010fd77d2fc1b41684a2d06699
https://doi.org/10.1073/pnas.1915141116
https://doi.org/10.1073/pnas.1915141116