Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Olga Kuchment"'
Autor:
Nicholas M Levinson, Olga Kuchment, Kui Shen, Matthew A Young, Michael Koldobskiy, Martin Karplus, Philip A Cole, John Kuriyan
Publikováno v:
PLoS Biology, Vol 4, Iss 5, p e144 (2006)
The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180 degrees with
Externí odkaz:
https://doaj.org/article/cf9f05868898426b810f60264dfb10c1
Autor:
Holger Sondermann, Jodi Gureasko, Dafna Bar-Sagi, John Kuriyan, Olga Kuchment, Debora L. Makino
Publikováno v:
Proceedings of the National Academy of Sciences. 107:3430-3435
Membrane-bound Ras is activated by translocation of the Son of Sevenless (SOS) protein to the plasma membrane. SOS is inactive unless Ras is bound to an allosteric site on SOS, and the Dbl homology (DH) and Pleckstrin homology (PH) domains of SOS (th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccad0ca6283e7e81eed157999d6af67
https://doi.org/10.1073/pnas.0913915107
https://doi.org/10.1073/pnas.0913915107
Autor:
Tanja Kortemme, Holger Sondermann, Tanya S. Freedman, Olga Kuchment, John Kuriyan, Gregory D. Friedland
Publikováno v:
Structure. 17:41-53
SummaryThe Ras-specific nucleotide exchange factor Son of sevenless (Sos) is inactive without Ras bound to a distal allosteric site. In contrast, the catalytic domain of Ras guanine nucleotide releasing factor 1 (RasGRF1) is active intrinsically. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bbd964e95a36f726d0791e09e68241
https://doi.org/10.1016/j.str.2008.11.004
https://doi.org/10.1016/j.str.2008.11.004
Autor:
Mario Rivera, Adriana Altuve, David R. Benson, Olga Kuchment, Simon Terzyan, Aaron B. Cowley, Xuejun Zhang
Publikováno v:
Biochemistry. 41:11566-11581
As part of a larger effort to engineer the stability and hemin-binding properties of microsomal (Mc) cytochromes b(5) into rat liver outer mitochondrial membrane (OM) cytochrome (cyt) b(5), several mutants of rat OM cyt b(5) were prepared to study th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7c9e7d3b722c1c0860cc46029fc88b
https://doi.org/10.1021/bi026005l
https://doi.org/10.1021/bi026005l
Autor:
Olga Kuchment, Michael A. Koldobskiy, Matthew A. Young, Philip A. Cole, Martin Karplus, Kui Shen, Nicholas M. Levinson, John Kuriyan
Publikováno v:
PLoS biology, vol 4, iss 5
PLoS Biology, Vol 4, Iss 5, p e144 (2006)
PLoS Biology
PLoS Biology, Vol 4, Iss 5, p e144 (2006)
PLoS Biology
The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180 degrees with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bae9dca869dc1528d22036c66b15899
https://escholarship.org/uc/item/9k87g3k7
https://escholarship.org/uc/item/9k87g3k7
Autor:
Michelle L. Sippel, Svetlana Silchenko, Olga Kuchment, David R. Benson, Mario Rivera, Adriana Altuve, A. Grant Mauk
Publikováno v:
Biochemical and biophysical research communications. 273(2)
Cytochrome b(5) from the outer mitochondrial membrane of rat liver (OM cyt b(5)) is substantially more stable to thermal and chemical denaturation than cytochrome b(5) from the endoplasmic reticulum of bovine liver (microsomal, or Mc cyt b(5)). In co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce29d7d27d20d10c51e88491031ee4f
https://pubmed.ncbi.nlm.nih.gov/10873629
https://pubmed.ncbi.nlm.nih.gov/10873629