Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Olga Kavetskaia"'
Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
Autor:
Volker Fischer, Olga Kavetskaia, Jens Sydor, Bruce W. Surber, Anthony J. Lee, Sonia M. de Morais, Rajeev M. Menon, Junli Ma, Jianwei Shen, Michael Serby, Prajakta S. Badri
Publikováno v:
Drug Metabolism and Disposition. 44:1148-1157
Ombitasvir (also known as ABT-267) is a potent inhibitor of hepatitis C virus (HCV) nonstructural protein 5A (NS5A), which has been developed in combination with paritaprevir/ritonavir and dasabuvir in a three direct-acting antiviral oral regimens fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a788c77672d9dd09e8c905cc749a880a
https://doi.org/10.1124/dmd.115.067496
https://doi.org/10.1124/dmd.115.067496
Autor:
Kennan C. Marsh, Volker Fischer, Jianwei Shen, Anthony J. Lee, Olga Kavetskaia, Aimee Reed, Xiaomei Zhang, Rajeev M. Menon, Michael Serby, Amit Khatri
Publikováno v:
Drug Metabolism and Disposition. 44:1164-1173
Paritaprevir (also known as ABT-450), a potent NS3-4A serine protease inhibitor [identified by AbbVie (North Chicago, IL) and Enanta Pharmaceuticals (Watertown, MA)] of the hepatitis C virus (HCV), has been developed in combination with ombitasvir an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109ebe4251cae8389a2b6aa1769665d2
https://doi.org/10.1124/dmd.115.067488
https://doi.org/10.1124/dmd.115.067488
Autor:
Jens Sydor, Olga Kavetskaia, Volker Fischer, Marjoleen Nijsen, Daniel A.J. Bow, Jinrong Liu, Sonia M. de Morais, Mohamad Shebley
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(7)
To assess drug-drug interaction (DDI) potential for the three direct-acting antiviral (3D) regimen of ombitasvir, dasabuvir, and paritaprevir, in vitro studies profiled drug-metabolizing enzyme and transporter interactions. Using mechanistic static a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136523a59d2c7e2f8e0e0aaa70b3619d
https://pubmed.ncbi.nlm.nih.gov/28483778
https://pubmed.ncbi.nlm.nih.gov/28483778
Publikováno v:
Biomedical Chromatography. 24:759-767
This paper describes the quantitation of acyl-glucuronide metabolites (M26 and M5) of a cardiovascular-drug (torcetrapib) from monkey urine, in the absence of their reference standards. LC/MS/MS assays for M1 and M4 (aglycones of M26 and M5, respecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4c727d9cbb58e3be08b72b98bdab4c
https://doi.org/10.1002/bmc.1360
https://doi.org/10.1002/bmc.1360
Publikováno v:
Journal of Chromatography B. 863:1-8
Hydrophilic interaction chromatography (HILIC) is an effective technique for retaining and separating polar compounds. This approach offers several advantages for bioanalytical liquid chromatography/mass spectrometry, considering that a majority of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027f5d40eee6f641bad0426dbe65b64c
https://doi.org/10.1016/j.jchromb.2007.11.036
https://doi.org/10.1016/j.jchromb.2007.11.036
Autor:
Honggang Bi, Rachael Leverence, Michael J. Avery, Olga Kavetskaia, Cornelis E.C.A. Hop, Arkady I. Gusev
Publikováno v:
Biomedical Chromatography. 21:1143-1150
This paper presents a study of the signal suppression and enhancement effects in assays based on HPLC-ESI-MS/MS detection. The major focus was to investigate the effect of signal suppression/enhancement of typical co-administered (concomitant) medica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaa6c666ab5ef9b5688576ecab32467
https://doi.org/10.1002/bmc.863
https://doi.org/10.1002/bmc.863
Autor:
Volker Fischer, Anthony J. Lee, Michael Serby, Olga Kavetskaia, Aimee Reed, Xiaomei Zhang, Xia Wan, Rajeev M. Menon, Kennan C. Marsh, Jianwei Shen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(8)
Dasabuvir [also known as ABT-333 or N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide] is a potent non-nucleoside NS protein 5B polymerase inhibitor of the hepatitis C virus (HCV) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac37bb27fa323acbf75b98bc0eb19528
https://pubmed.ncbi.nlm.nih.gov/27179126
https://pubmed.ncbi.nlm.nih.gov/27179126
Publikováno v:
Analytical Chemistry. 78:1331-1336
A novel approach for on-line introduction of internal standard (IS) for quantitative analysis using LC-MS/MS has been developed. In this approach, analyte and IS are introduced into the sample injection loop in different steps. Analyte is introduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e39dd066a18ebac3f44202ca0ecca2
https://doi.org/10.1021/ac051806q
https://doi.org/10.1021/ac051806q
Autor:
Honggang Bi, Olga Kavetskaia, David Waddell, Arkady I. Gusev, Karthik Srinivasan, Yazen Alnouti
Publikováno v:
Journal of Chromatography A. 1080:99-106
A technique using a fully automated on-line solid phase extraction (SPE) system (Symbiosis, Spark Holland) combined with liquid chromatography (LC)–mass spectrometry (MS/MS) has been investigated for fast bioanalytical method development, method va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbe69db103c74845d80005ccdd18d21
https://doi.org/10.1016/j.chroma.2005.04.056
https://doi.org/10.1016/j.chroma.2005.04.056
Publikováno v:
Dried Blood Spots: Applications and Techniques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84e26e1c9d730d8b26af7098a47d7f23
https://doi.org/10.1002/9781118890837.ch20
https://doi.org/10.1002/9781118890837.ch20
