Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Olga Ignatovich"'
Autor:
Nicholas Wilson, Richard Carvajal, Irina Shapiro, Anthony Tolcher, Dhan Chand, Marc Van Dijk, Anna Wijatyk, Jennifer Buell, James Strauss, Claire Galand, Vignesh Venkatraman, Marilyn Marques, Min Lim, Benjamin Morin, Olga Ignatovich, Mark Findeis, Dennis Underwood, Lernik Ohanjanian, David Savitsky
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/91057e4b0fe44f10b2f362fe7939da70
Autor:
Olga Udartseva, Malgorzata Pupecka-Swider, Pilar Garcia-Broncano, Naxin Guo, Spencer Campbell, Elizabeth Klakus, Rebecca Ward, Priyadarshini Iyer, Christine Brittsan, Beth Wensley, Benjamin Morin, Andrew Slee, Dhan Chand, Claire Galand, Olga Ignatovich, Emmanuel Briend, David Savitsky
Publikováno v:
Cancer Research. 82:2906-2906
Background: Ig-Like Transcript 2 (ILT2, LILRB1) is an inhibitory receptor prominently expressed on resting macrophages, monocytes, and dendritic cells (DCs), with variable expression on CD4+ T cells, CD8+ T cells, B cells, NK cells, and NKT cells in
Autor:
Nicholas S. Wilson, Dhan Chand, Min Lim, Dennis J. Underwood, Anthony W. Tolcher, Irina M. Shapiro, Anna Wijatyk, Mark Findeis, David Savitsky, Richard D. Carvajal, Jennifer Buell, Vignesh Venkatraman, Lernik Ohanjanian, James Strauss, Marc Van Dijk, Marilyn Marques, Claire Galand, Olga Ignatovich, Benjamin Morin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background CD137 (4-1BB) represents a costimulatory pathway that promotes T, NK, and dendritic cell effector functions favorable for antitumor immunity. The extracellular domain of CD137, comprised of four cysteine-rich domains (CRD-I, CRD-II, CRD-II
Autor:
Randi Gombos, Matthew Costa, Claire Galand, Nicholas S. Wilson, Olga Ignatovich, Cailin E. Joyce, Dennis J. Underwood, David Savitsky, Benjamin Morin, Vignesh Venkatraman, Cornelia Anne Mundt, Min Lim, Christina Riordan, R.B. Stein, Rebecca M. Ward, Yanping Xiao, Dhan Chand, Mark Findeis, Marc van Dijk
Publikováno v:
Journal of Clinical Oncology. 37:e14005-e14005
e14005 Background: Agonist antibodies targeting CD137 are potent inducers of tumor-reactive T cell proliferation, cytokine production, and cytotoxicity, and have been explored clinically for their ability to enhance immune cell-mediated destruction o
Autor:
Steven Grant, Suzanne J. Suchard, Robert P. Rehfuss, Steven G. Nadler, Kathleen M. Gillooly, Anish Suri, Robert Kuhn, Ruth Brosius, Yifan Zhang, Rathna Ravishankar, Kathy A Mink, Aaron P. Yamniuk, Sandra Rex-Rabe, Jenny Xie, Philip Drew, Luisa Salter-Cid, Kimberly S Waggie, James William Bryson, Olga Ignatovich, Lin Cheng, Laura Price, Xiadi Zhou, Yongmi An, James K. Tamura, Virna Borowski, Xiaoxia Yang, Bozena Abramczyk, Vojkan Susulic
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(9)
CD40–CD40L interactions play a critical role in regulating immune responses. Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrated positive clinical effects in patients with autoimmune diseases; however, incidents of thromboembolism
Publikováno v:
Journal of Molecular Biology. 268:69-77
Sequence diversity in the human antibody repertoire is generated in two steps: by the combinatorial assembly of V gene segments and by somatic hypermutation. Here, we have characterised these processes for the lambda (lambda) light chain using a libr
Autor:
Catherine A. Fleener, Dawn K. Stetsko, Patricia M. Davis, James K. Tamura, Steven G. Nadler, Haiqing Wang, James William Bryson, Ruth Brosius, Plummer Christopher, Steven Grant, Theodora W. Salcedo, Olga Ignatovich, Lumelle A. Schneeweis, Suzanne J. Suchard, Selena Kansal, Zheng Yang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 191(9)
Targeting the CD28-CD80/86 pathway with an anti-CD28 antagonist is a promising alternative to current therapies for autoimmunity. However, attempts at generating conventional anti-CD28 mAbs lacking stimulatory activity has been challenging. In this s
Autor:
Greg Winter, I M Tomlinson, Marie-Paule Lefranc, Jean-Pol Frippiat, Samuel C. Williams, Olga Ignatovich
Publikováno v:
Journal of Molecular Biology. 264:220-232
We recently completed a map of the human immunoglobulin lambda (IGL) locus on chromosome 22q11.2 and showed that the V lambda genes are arranged in three distinct clusters, each containing members of different V lambda families. We have now sequenced
Publikováno v:
Nucleic Acids Research. 23:4616-4619
The protein sequence derived from a cloned yeast gene and partial cDNA has high sequence identity to 40S ribosomal subunit S5 proteins of higher eukaryotic origin. The open reading frame of the gene is flanked by consensus sequence motifs characteris
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 911
This protocol describes a method for creation of a highly diverse and functional synthetic phage-displayed repertoire of fully human domain antibodies (dAbs). The repertoire is based on two human frameworks (one VH and one Vκ) that express well in b