Zobrazeno 1 - 10
of 400
pro vyhledávání: '"Olga I Lavrik"'
Autor:
Maria V. Sukhanova, Rashid O. Anarbaev, Ekaterina A. Maltseva, Mikhail M. Kutuzov, Olga I. Lavrik
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The formation of nuclear biomolecular condensates is often associated with local accumulation of proteins at a site of DNA damage. The key role in the formation of DNA repair foci belongs to PARP1, which is a sensor of DNA damage and catalyz
Externí odkaz:
https://doaj.org/article/4345651c06e44d94a1015d06dede364d
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190782 (2018)
Replication protein A (RPA) and the xeroderma pigmentosum group A (XPA) protein are indispensable for both pathways of nucleotide excision repair (NER). Here we analyze the interaction of RPA and XPA with DNA containing a flap and different size gaps
Externí odkaz:
https://doaj.org/article/6dcf5505b6414436929e59d5f3fe70f0
Autor:
Ekaterina A Belousova, Inna A Vasil'eva, Nina A Moor, Timofey S Zatsepin, Tatiana S Oretskaya, Olga I Lavrik
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e68576 (2013)
Lesions in the DNA arise under ionizing irradiation conditions or various chemical oxidants as a single damage or as part of a multiply damaged site within 1-2 helical turns (clustered lesion). Here, we explored the repair opportunity of the apurinic
Externí odkaz:
https://doaj.org/article/b00a447fbb75479c8d6acbe835c3a24d
Autor:
Yuliya S. Krasikova, Ekaterina A. Maltseva, Svetlana N. Khodyreva, Alexey N. Evdokimov, Nadejda I. Rechkunova, Olga I. Lavrik
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 814 (2024)
Nucleotide excision repair (NER) is the most universal repair pathway, which removes a wide range of DNA helix-distorting lesions caused by chemical or physical agents. The final steps of this repair process are gap-filling repair synthesis and subse
Externí odkaz:
https://doaj.org/article/173960b440204f52bfbfc23513e3f93f
Autor:
Natalia A. Lebedeva, Rashid O. Anarbaev, Ekaterina A. Maltseva, Maria V. Sukhanova, Nadejda I. Rechkunova, Olga I. Lavrik
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6927 (2024)
Non-membrane compartments or biomolecular condensates play an important role in the regulation of cellular processes including DNA repair. Here, an ability of XRCC1, a scaffold protein involved in DNA base excision repair (BER) and single-strand brea
Externí odkaz:
https://doaj.org/article/b367756275d94f7d868901c96183ce06
Autor:
Emilie Bertrand, Clément Demongin, Ioana Dobra, Juan Carlos Rengifo-Gonzalez, Anastasia S. Singatulina, Maria V. Sukhanova, Olga I. Lavrik, David Pastré, Loic Hamon
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract FUS is an RNA-binding protein involved in familiar forms of ALS and FTLD that also assembles into fibrillar cytoplasmic aggregates in some neurodegenerative diseases without genetic causes. The self-adhesive prion-like domain in FUS generate
Externí odkaz:
https://doaj.org/article/9379e4e83d2b416ebc9af2f57a01912f
Autor:
Kseniya S. Kovaleva, Olga I. Yarovaya, Irina A. Chernyshova, Alexandra L. Zakharenko, Sergey V. Cheresiz, Amirhossein Azimirad, Andrey G. Pokrovsky, Olga I. Lavrik, Nariman F. Salakhutdinov
Publikováno v:
Molbank, Vol 2023, Iss 4, p M1743 (2023)
New imidazolidine-2,4,5-triones with norabietic, nordehydroabietic, and adamantane substituents were synthesized by reacting oxalyl chloride and the corresponding ureas, providing good yields. Bioisosteric replacement of the ureide group with a parab
Externí odkaz:
https://doaj.org/article/762c351df9fd453b962ba98d14d82149
Autor:
Svetlana N. Khodyreva, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Alina S. Kochetkova, Alexandra A. Yamskikh, Ekaterina A. Maltseva, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian, Olga I. Lavrik
Publikováno v:
Cells, Vol 13, Iss 4, p 302 (2024)
Base excision repair (BER) is the predominant pathway for the removal of most forms of hydrolytic, oxidative, and alkylative DNA lesions. The precise functioning of BER is achieved via the regulation of each step by regulatory/accessory proteins, wit
Externí odkaz:
https://doaj.org/article/0983d4f52fdc49359c9bed4462992ed4
Autor:
Oksana V. Salomatina, Tatyana E. Kornienko, Alexandra L. Zakharenko, Nina I. Komarova, Chigozie Achara, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Publikováno v:
Molecules, Vol 29, Iss 3, p 581 (2024)
Deoxycholic acid derivatives containing various heterocyclic functional groups at C-3 on the steroid scaffold were designed and synthesized as promising dual tyrosyl-DNA phosphodiesterase 1 and 2 (TDP1 and TDP2) inhibitors, which are potential target
Externí odkaz:
https://doaj.org/article/f7a6940d786f428597863fdfcc30635e
Autor:
Tatyana E. Kornienko, Arina A. Chepanova, Alexandra L. Zakharenko, Aleksandr S. Filimonov, Olga A. Luzina, Nadezhda S. Dyrkheeva, Valeriy P. Nikolin, Nelly A. Popova, Nariman F. Salakhutdinov, Olga I. Lavrik
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1210 (2024)
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme and one of the causes of tumor resistance to topoisomerase 1 inhibitors such as topotecan. Inhibitors of this Tdp1 in combination with topotecan may improve the effectiveness of
Externí odkaz:
https://doaj.org/article/0d520dedd8ff4561923041ccb75fccda