Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Olga I, Isaeva"'
Autor:
Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok, Esther Koop, Petra M. Nederlof, Mark Opdam, Philip C. Schouten, Sabine Siesling, Charlaine van Steenis, Adri C. Voogd, Willem Vreuls, Roberto F. Salgado, Sabine C. Linn, Marjanka K. Schmidt
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in this population remains unclear. In addition, whether BRCA1-related bio
Externí odkaz:
https://doaj.org/article/ddff242b9c864f39864f3885aee7bad4
Autor:
Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the sys
Externí odkaz:
https://doaj.org/article/b656e036ddb5458b8a3bb50ca339a61b
Autor:
Dora Hammerl, John W. M. Martens, Mieke Timmermans, Marcel Smid, Anita M. Trapman-Jansen, Renée Foekens, Olga I. Isaeva, Leonie Voorwerk, Hayri E. Balcioglu, Rebecca Wijers, Iris Nederlof, Roberto Salgado, Hugo Horlings, Marleen Kok, Reno Debets
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Only a subset of triple negative breast cancer patients respond to immunotherapy. Here, the authors analysed spatial immune contextures, which can be captured by a gene classifier, in relation to genomic alterations, mechanisms of T cell evasion and
Externí odkaz:
https://doaj.org/article/c987387dc5c94a1b93ac3cb4c523d2fd
Autor:
Anastasia Gangaev, Steven L. C. Ketelaars, Olga I. Isaeva, Sanne Patiwael, Anna Dopler, Kelly Hoefakker, Sara De Biasi, Lara Gibellini, Cristina Mussini, Giovanni Guaraldi, Massimo Girardis, Cami M. P. Talavera Ormeno, Paul J. M. Hekking, Neubury M. Lardy, Mireille Toebes, Robert Balderas, Ton N. Schumacher, Huib Ovaa, Andrea Cossarizza, Pia Kvistborg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a respon
Externí odkaz:
https://doaj.org/article/2ce4c1ed10aa40a0a43f6286be3ee6c6
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since the start of the COVID-19 pandemic, mutations have led to the emergence of new SARS-CoV-2 variants, and some of these have become prominent or dominant variants of concern. This natural course of development can have an impact on how protective
Externí odkaz:
https://doaj.org/article/96414d28266d465bb4187ecc8aca15c5
Autor:
Leonie Voorwerk, Olga I. Isaeva, Hugo M. Horlings, Sara Balduzzi, Maksim Chelushkin, Noor A. M. Bakker, Elisa Champanhet, Hannah Garner, Karolina Sikorska, Claudette E. Loo, Inge Kemper, Ingrid A. M. Mandjes, Michiel de Maaker, Jasper J. L. van Geel, Jorianne Boers, Maaike de Boer, Roberto Salgado, Marloes G. J. van Dongen, Gabe S. Sonke, Karin E. de Visser, Ton N. Schumacher, Christian U. Blank, Lodewyk F. A. Wessels, Agnes Jager, Vivianne C. G. Tjan-Heijnen, Carolien P. Schröder, Sabine C. Linn, Marleen Kok
Publikováno v:
Nature Cancer, 4, 535-549. Springer Nature
Nature Cancer, 4(4), 535-549. Nature Research
Nature Cancer, 4(4), 535-549. Nature Research
Invasive lobular breast cancer (ILC) is the second most common histological breast cancer subtype, but ILC-specific trials are lacking. Translational research revealed an immune-related ILC subset, and in mouse ILC models, synergy between immune chec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173e4cc0d70da59f93de91b9372cee78
https://doi.org/10.1038/s43018-023-00542-x
https://doi.org/10.1038/s43018-023-00542-x
Autor:
Olga S, Blomberg, Lorenzo, Spagnuolo, Hannah, Garner, Leonie, Voorwerk, Olga I, Isaeva, Ewald, van Dyk, Noor, Bakker, Myriam, Chalabi, Chris, Klaver, Maxime, Duijst, Kelly, Kersten, Marieke, Brüggemann, Dorien, Pastoors, Cheei-Sing, Hau, Kim, Vrijland, Elisabeth A M, Raeven, Daphne, Kaldenbach, Kevin, Kos, Inna S, Afonina, Paulien, Kaptein, Louisa, Hoes, Willemijn S M E, Theelen, Paul, Baas, Emile E, Voest, Rudi, Beyaert, Daniela S, Thommen, Lodewyk F A, Wessels, Karin E, de Visser, Marleen, Kok
Publikováno v:
Cancer cell.
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::858404ab7e5b5d36c2dd670afa56af35
https://pubmed.ncbi.nlm.nih.gov/36525971
https://pubmed.ncbi.nlm.nih.gov/36525971
Autor:
Krishna Kadaveru, John Hambor, Clarissa Campbell, Alexander Y. Rudensky, Cheryl Mai, Daniel Konstantinovsky, Peter T. McKenney, Ruben J. Ramos, Olga I Isaeva, Chun-Jun Guo, Michail Schizas, Justin R. Cross, Jacob Verter, Wen-Bing Jin, Sara Violante
Publikováno v:
Nature. 581:475-479
Intestinal health relies on the immunosuppressive activity of CD4+ regulatory T (Treg) cells1. Expression of the transcription factor Foxp3 defines this lineage, and can be induced extrathymically by dietary or commensal-derived antigens in a process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ba5447a9b51cd120c59b91735e0d748
https://doi.org/10.1038/s41586-020-2193-0
https://doi.org/10.1038/s41586-020-2193-0
Autor:
Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, Kelly Kersten, Marieke Brüggemann, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth A.M. Raeven, Daphne Kaldenbach, Kevin Kos, Inna S. Afonina, Paulien Kaptein, Louisa Hoes, Willemijn S.M.E. Theelen, Paul Baas, Emile E. Voest, Rudi Beyaert, Daniela S. Thommen, Lodewyk F.A. Wessels, Karin E. de Visser, Marleen Kok
Publikováno v:
CANCER CELL
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad37e511061ec36826986b3010056ea
https://doi.org/10.1016/j.ccell.2022.11.014
https://doi.org/10.1016/j.ccell.2022.11.014
Autor:
Sanne Patiwael, Christian U. Blank, Ton N. Schumacher, Antoni Ribas, John B. A. G. Haanen, Anastasia Gangaev, Daisy Philips, Dirk Schadendorf, Joost H. van den Berg, Maartje W. Rohaan, Bastian Schilling, Elisa A. Rozeman, Pia Kvistborg, Olga I. Isaeva
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) have revolutionized the treatment of melanoma patients. Based on early studies addressing the mechanism of action,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994323e563648a11d8ffa0127b701604
https://doi.org/10.1073/pnas.2102849118
https://doi.org/10.1073/pnas.2102849118