Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Olga Hrušková"'
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93322 (2014)
Numerous Δ12-, Δ15- and multifunctional membrane fatty acid desaturases (FADs) have been identified in fungi, revealing great variability in the enzymatic specificities of FADs involved in biosynthesis of polyunsaturated fatty acids (PUFAs). Here,
Externí odkaz:
https://doaj.org/article/3671f3506616491aafd2fa2e8ef28636
Autor:
Zuzana Vinterová, Hana Sychrová, Václava Bauerová, Olga Hrušková-Heidingsfeldová, Iva Pichová, Jiří Dostál
Publikováno v:
Journal of Microbiology. 51:336-344
Secreted aspartic proteinase Sapp1p of Candida parapsilosis represents one of the factors contributing to the pathogenicity of the fungus. The proteinase is synthesized as an inactive pre-pro-enzyme, but only processed Sapp1p is secreted into extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbaed0a5f7bf617408b1cda0e9932f5
https://doi.org/10.1007/s12275-013-2422-4
https://doi.org/10.1007/s12275-013-2422-4
Publikováno v:
Canadian Journal of Microbiology. 58:678-681
Vacuoles play an important role in the physiology of pathogenic Candida spp. However, information on Candida albicans vacuolar enzymes, their properties, and regulation is scarce. Expression of the genes APR1 and CPY1 encoding vacuolar aspartic prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18039ae233e3b476839357ecf3d18b76
https://doi.org/10.1139/w2012-030
https://doi.org/10.1139/w2012-030
Autor:
Jiří Dostál, Petr Pachl, Iva Pichová, Jiří Brynda, Pavlina Rezacova, Olga Hrušková-Heidingsfeldová
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 27:160-165
Secreted aspartic proteases (Saps) are extracellular proteolytic enzymes that enhance the virulence of Candida pathogens. These enzymes therefore represent possible targets for therapeutic drug design. Saps are inhibited by nanomolar concentrations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b110de7a36f914e2de0384a379d89670
https://doi.org/10.3109/14756366.2011.627508
https://doi.org/10.3109/14756366.2011.627508
Publikováno v:
Current Enzyme Inhibition. 7:125-129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23734b82f6739508799af43994bdf9ee
https://doi.org/10.2174/157340811796575263
https://doi.org/10.2174/157340811796575263
Autor:
Olga Hrušková-Heidingsfeldová, Jiří Dostál, Jana Havlíková, Filip Majer, Martin Hradilek, Iva Pichová
Publikováno v:
bchm. 390:259-268
Secreted aspartic proteinases (Sap) play a role in the virulence of pathogenic Candida spp. Candida parapsilosis possesses three genes encoding these enzymes: SAPP1, SAPP2, and SAPP3. We analyzed the expression of the SAPP1 and SAPP2 genes and the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7222290868ade4b7e96ebd873ad86a
https://doi.org/10.1515/bc.2009.034
https://doi.org/10.1515/bc.2009.034
Autor:
Petr Hamal, Jiri Dostal, L. Pavlíčková, Tomáš Ruml, Iva Pichová, Olga Hrušková-Heidingsfeldová, Milan Souček
Publikováno v:
Journal of Clinical Microbiology. 41:712-716
The yeasts of the genus Candida are opportunistic pathogens associated with the rising incidence of life-threatening infections in immunocompromised individuals. Secretion of aspartic proteinases has been determined to be one of the virulence factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1d5bcad699215d177e6c5ee3bee0fc
https://doi.org/10.1128/jcm.41.2.712-716.2003
https://doi.org/10.1128/jcm.41.2.712-716.2003
Autor:
Tomáš Ruml, Petr Hamal, Jarmila Pazlarová, Jiří Dostál, Iva Pichová, Olga Hrušková-Heidingsfeldová
Publikováno v:
Collection of Czechoslovak Chemical Communications. 66:1707-1719
Opportunistic pathogens of the genusCandidaproduce secreted aspartic proteinases (Saps) that are considered as one of the virulence factors. While Saps ofC. albicansandC. tropicalishave been studied extensively, information concerning proteinases sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1237ebd942b2ef9dfdfeac78b1e51c43
https://doi.org/10.1135/cccc20011707
https://doi.org/10.1135/cccc20011707
Autor:
Vladimír Havlíček, Olga Hrušková-Heidingsfeldová, Martin Andreansky, Tomáš Ruml, Aleš Zábranský, Iva Pichová, Eric Hunter
Publikováno v:
Virology. 245:250-256
Mason–Pfizer monkey virus (M-PMV) proteinase, released by the autocatalytic cleavage of Gag-Pro and Gag-Pro-Pol polypeptide precursors, catalyzes the processing of viral precursors to yield the structural proteins and enzymes of the virion. In retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f11b605a0ed6be9c77aa28f9e73ef5d
https://doi.org/10.1006/viro.1998.9173
https://doi.org/10.1006/viro.1998.9173
Publikováno v:
Folia microbiologica. 59(6)
Vacuolar hydrolases have been thoroughly characterized in Saccharomyces cerevisiae, but their homologues in the fungal pathogen Candida albicans have received less attention. The genes APR1 and CPY1 of C. albicans encode putative vacuolar aspartic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e49d97e723ba6643c63bb4c439be1ab
https://pubmed.ncbi.nlm.nih.gov/24880249
https://pubmed.ncbi.nlm.nih.gov/24880249