Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Olga Horakova"'
Autor:
Andrea Benova, Michaela Ferencakova, Kristina Bardova, Jiri Funda, Jan Prochazka, Frantisek Spoutil, Tomas Cajka, Martina Dzubanova, Tim Balcaen, Greet Kerckhofs, Wouter Willekens, G. Harry van Lenthe, Arzuv Charyyeva, Glenda Alquicer, Alena Pecinova, Tomas Mracek, Olga Horakova, Roman Coupeau, Morten Svarer Hansen, Martin Rossmeisl, Jan Kopecky, Michaela Tencerova
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose metabolism and bone homeostasis in obesity. However, the impact of omega-3 PUFAs on
Externí odkaz:
https://doaj.org/article/4561b44395d7415182b87647a147ec6e
Autor:
Olga Horakova, Gabriella Sistilli, Veronika Kalendova, Kristina Bardova, Marko Mitrovic, Tomas Cajka, Ilaria Irodenko, Petra Janovska, Karoline Lackner, Jan Kopecky, Martin Rossmeisl
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionNon-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with high-fat diet promoted NAFLD progression in C57BL/6J mice. Due to possible differences
Externí odkaz:
https://doaj.org/article/8f805a1becbe4000a52309d7f53c4d18
Autor:
Petra Janovska, Petr Zouhar, Kristina Bardova, Jakub Otahal, Marek Vrbacky, Tomas Mracek, Katerina Adamcova, Lucie Lenkova, Jiri Funda, Tomas Cajka, Zdenek Drahota, Sara Stanic, Arild C. Rustan, Olga Horakova, Josef Houstek, Martin Rossmeisl, Jan Kopecky
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101683- (2023)
Objective: Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system in response to cold or diet, contributing to both thermal and energy homeostasis. Other mech
Externí odkaz:
https://doaj.org/article/31f0b59f9117425794b61598c518ae9c
Autor:
Andrea Benova, Michaela Ferencakova, Kristina Bardova, Jiri Funda, Jan Prochazka, Frantisek Spoutil, Tomas Cajka, Martina Dzubanova, Tim Balcaen, Greet Kerckhofs, Wouter Willekens, G. Harry van Lenthe, Glenda Alquicer, Alena Pecinova, Tomas Mracek, Olga Horakova, Martin Rossmeisl, Jan Kopecky, Michaela Tencerova
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101598- (2022)
Objective: The use of thiazolidinediones (TZDs) as insulin sensitizers has been shown to have side effects including increased accumulation of bone marrow adipocytes (BMAds) associated with a higher fracture risk and bone loss. A novel TZD analog MSD
Externí odkaz:
https://doaj.org/article/069e2f335a58411aad710c3d1311ce2a
Autor:
Gabriella Sistilli, Veronika Kalendova, Tomas Cajka, Illaria Irodenko, Kristina Bardova, Marina Oseeva, Petr Zacek, Petra Kroupova, Olga Horakova, Karoline Lackner, Amalia Gastaldelli, Ondrej Kuda, Jan Kopecky, Martin Rossmeisl
Publikováno v:
Nutrients, Vol 13, Iss 2, p 437 (2021)
Preclinical evidence suggests that n-3 fatty acids EPA and DHA (Omega-3) supplemented as phospholipids (PLs) may be more effective than triacylglycerols (TAGs) in reducing hepatic steatosis. To further test the ability of Omega-3 PLs to alleviate liv
Externí odkaz:
https://doaj.org/article/6cc4ea4956764e4381f0e749386d6108
Autor:
Kristina Bardova, Jiri Funda, Radek Pohl, Tomas Cajka, Michal Hensler, Ondrej Kuda, Petra Janovska, Katerina Adamcova, Ilaria Irodenko, Lucie Lenkova, Petr Zouhar, Olga Horakova, Pavel Flachs, Martin Rossmeisl, Jerry Colca, Jan Kopecky
Publikováno v:
Nutrients, Vol 12, Iss 12, p 3737 (2020)
Long-chain n-3 polyunsaturated fatty acids (Omega-3) and anti-diabetic drugs thiazolidinediones (TZDs) exhibit additive effects in counteraction of dietary obesity and associated metabolic dysfunctions in mice. The underlying mechanisms need to be cl
Externí odkaz:
https://doaj.org/article/2aca0db9edf94d8ea6987a0e3a46e0f0
Autor:
Petra Kroupova, Evert M. van Schothorst, Jaap Keijer, Annelies Bunschoten, Martin Vodicka, Ilaria Irodenko, Marina Oseeva, Petr Zacek, Jan Kopecky, Martin Rossmeisl, Olga Horakova
Publikováno v:
Nutrients, Vol 12, Iss 7, p 2037 (2020)
Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-contai
Externí odkaz:
https://doaj.org/article/fee2d16b67964438835710c26063ce99
Autor:
Katerina Adamcova, Olga Horakova, Kristina Bardova, Petra Janovska, Marie Brezinova, Ondrej Kuda, Martin Rossmeisl, Jan Kopecky
Publikováno v:
Marine Drugs, Vol 16, Iss 12, p 515 (2018)
We found previously that white adipose tissue (WAT) hyperplasia in obese mice was limited by dietary omega-3 polyunsaturated fatty acids (omega-3 PUFA). Here we aimed to characterize the underlying mechanism. C57BL/6N mice were fed a high-fat diet su
Externí odkaz:
https://doaj.org/article/8d95e460303942f7a0595c5428cd0a1f
Autor:
Olga Horakova, Jana Hansikova, Kristina Bardova, Alzbeta Gardlo, Martina Rombaldova, Ondrej Kuda, Martin Rossmeisl, Jan Kopecky
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155776 (2016)
Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome. Development of obesity is also linked to changes in fatty acid and amino acid metabolism observed in anim
Externí odkaz:
https://doaj.org/article/be63d3d26fbf427f8b8ef7f632a9dcd6
Autor:
Olga Horakova, Dasa Medrikova, Evert M van Schothorst, Annelies Bunschoten, Pavel Flachs, Vladimir Kus, Ondrej Kuda, Kristina Bardova, Petra Janovska, Michal Hensler, Martin Rossmeisl, Rui Wang-Sattler, Cornelia Prehn, Jerzy Adamski, Thomas Illig, Jaap Keijer, Jan Kopecky
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43764 (2012)
Insulin resistance, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. This, in turn, contributes to a further damage of insulin signaling. Effective
Externí odkaz:
https://doaj.org/article/6c369ad1fc064c589162e6d74ea2dcba