BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

Autor: Alessandro Tancredi, Olga Gusyatiner, Pierre Bady, Michelle C. Buri, Rémy Lomazzi, Davide Chiesi, Mahmoud Messerer, Monika E. Hegi

Publikováno v: Cell Death and Disease, Vol 13, Iss 12, Pp 1-12 (2022)

Abstract Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with smal

Externí odkaz: https://doaj.org/article/f2a9f26c12994f11b4a43ca841fb4d30

Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Autor: Mor Mishkovsky, Olga Gusyatiner, Bernard Lanz, Cristina Cudalbu, Irene Vassallo, Marie-France Hamou, Jocelyne Bloch, Arnaud Comment, Rolf Gruetter, Monika E. Hegi

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable

Externí odkaz: https://doaj.org/article/63f02f86298445728f1acfcb8546e62d

Evolution patterns of glioblastoma from single-cell whole-genome sequencings

Autor: Hyeok Choi, Woo Jong Cho, Olga Gusyatiner, Pierre Bady, Manuel Bueno, Roy Daniel, Keith Harshman, Julien Marquis, Monika Hegi, Leeyoung Park

Publikováno v: WFNOS 2022 Abstract Book.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3190d8197afb1eeb06cdf4cef159d740
https://doi.org/10.14791/btrt.2022.10.f-1262

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Autor: Jean-Philippe Brouland, Cristina Cudalbu, Lijing Xin, Andreas F. Hottinger, Roy Thomas Daniel, Monika E. Hegi, Pierre Bady, Marta Lai, Olga Gusyatiner, Mario Lepore, Marie-France Hamou

Publikováno v: Acta neuropathologica communications, vol. 9, no. 1, pp. 133
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Acta Neuropathologica Communications
BioRxiv

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7278226f5c798527e12857fb894c162
https://serval.unil.ch/notice/serval:BIB_CB8B36AE633E

Hyperpolarized

Autor: Mor, Mishkovsky, Olga, Gusyatiner, Bernard, Lanz, Cristina, Cudalbu, Irene, Vassallo, Marie-France, Hamou, Jocelyne, Bloch, Arnaud, Comment, Rolf, Gruetter, Monika E, Hegi

Publikováno v: Scientific Reports

Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b40eba2d2a1b35e3de8d18ac682a3a09
https://pubmed.ncbi.nlm.nih.gov/33707647