Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Olga Gorelenkova Miller"'
Autor:
Olga Gorelenkova Miller, Kyle S Cole, Corey C Emerson, Dharmaraja Allimuthu, Marcin Golczak, Phoebe L Stewart, Eranthie Weerapana, Drew J Adams, John J Mieyal
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187991 (2017)
Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits infl
Externí odkaz:
https://doaj.org/article/1946c27c3e7a4148add6193db46da8d3
Autor:
Markus Bachschmid, Olga Gorelenkova Miller, Sandra L. Siedlak, John J. Mieyal, Sirui Jiang, Xiongwei Zhu, Jessica B. Behring, Reiko Matsui
Publikováno v:
Antioxidants & Redox Signaling. 25:967-982
Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcc8b8f24900f0dbbce63f159591d43
https://doi.org/10.1089/ars.2015.6598
https://doi.org/10.1089/ars.2015.6598
Autor:
Amy L. Wilson-Delfosse, Shu G. Chen, Nicole M. Milkovic, John J. Mieyal, Mark A. Wilson, Pierce L. Curran, Kyonghwan Choe, Chen Yao, Ajit Ray, Olga Gorelenkova Miller, Vijayalakshmi Ravindranath, Marcin Golczak, Wenzhang Wang, William M. Johnson, Xiongwei Zhu, Jiusheng Lin
Publikováno v:
Biochemistry. 55:4519-4532
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. Mutations in PARK7 (DJ-1) result in early onset autosomal recessive PD, and oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ddb03c05403e95c7125fa3aa11383f
https://doi.org/10.1021/acs.biochem.5b01132
https://doi.org/10.1021/acs.biochem.5b01132
Publikováno v:
Archives of Toxicology. 89:1439-1467
Posttranslational modifications of cysteine sulfhydryl (-SH) moieties, e.g., S-nitrosylation, S-glutathionylation, or S-sulfuration, play an important role in cellular response to oxidative stress. Reversible cysteine modifications alter protein func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02a1f12ddd67f9888c04cf2fd014c11
https://doi.org/10.1007/s00204-015-1496-7
https://doi.org/10.1007/s00204-015-1496-7
Publikováno v:
Antioxidantsredox signaling. 30(10)
Significance: Glutaredoxin (Grx)1, an evolutionarily conserved and ubiquitous enzyme, regulates redox signal transduction and protein redox homeostasis by catalyzing reversible S-glutathionylation. Grx1 plays different roles in different cell types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dcfafc46afa2cb6a207222b5840acd
https://pubmed.ncbi.nlm.nih.gov/29183158
https://pubmed.ncbi.nlm.nih.gov/29183158
Publikováno v:
Archives of toxicology. 90(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba5fdac42df82a9a713dc9747ccdebc
https://pubmed.ncbi.nlm.nih.gov/27083177
https://pubmed.ncbi.nlm.nih.gov/27083177
Autor:
Marcin Golczak, Eranthie Weerapana, Dharmaraja Allimuthu, John J. Mieyal, Olga Gorelenkova Miller, Corey C. Emerson, Phoebe L. Stewart, Kyle S. Cole, Drew J. Adams
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0187991 (2017)
PLoS ONE, Vol 12, Iss 11, p e0187991 (2017)
Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77404589ba30740781fafe7b2fcade64
https://doi.org/10.1371/journal.pone.0187991
https://doi.org/10.1371/journal.pone.0187991