Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Olga Gilicky"'
Autor:
Wu-Yan Zhang, Minsheng He, Chi-Li Chen, Zhijian Zhu, Philip John Hogan, Nicholas Dunwoody, Magnus Ronn, Olga Gilicky
Publikováno v:
Organic Process Research & Development. 21:377-386
Process research, development, and manufacture of TP-808 (1), a key intermediate for the discovery and manufacture of tetracycline analogues, is described. The process used for the preparation of 1 avoids chromatographic purifications and has been su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47609db48039900f2c880bd3b121566e
https://doi.org/10.1021/acs.oprd.7b00003
https://doi.org/10.1021/acs.oprd.7b00003
Autor:
Philip C. Hogan, Olga Gilicky, Zhimin Wang, Magnus Ronn, Danny Lafrance, Chi-Li Chen, John Niu, Wu-Yan Zhang, Nicholas Dunwoody
Publikováno v:
Organic Process Research & Development. 19:1784-1795
A robust, cost-effective, and high yielding manufacturing process for enantiomerically enriched (S)-allylic amine 3, a key intermediate for fully synthetic tetracyclines have been developed. Two novel and scalable asymmetric vinylations resulting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09646552ec175274a3463920d90aac93
https://doi.org/10.1021/acs.oprd.5b00274
https://doi.org/10.1021/acs.oprd.5b00274
Autor:
Wu-Yan Zhang, Zhijian Zhu, Philip C. Hogan, Magnus Ronn, Chi-Li Chen, John Niu, Yonghong Deng, Christopher E. Katz, Roger B. Clark, Xiao-Yi Xiao, Diana K. Hunt, Cuixiang Sun, Minsheng He, Olga Gilicky, Nicholas Dunwoody
Publikováno v:
Organic Process Research & Development. 17:838-845
Process research and development of the first fully synthetic broad spectrum 7-fluorotetracycline in clinical development is described. The process utilizes two key intermediates in a convergent approach. The key transformation is a Michael–Dieckma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8adac5b66737a518fc9a0ca8b62dbae8
https://doi.org/10.1021/op4000219
https://doi.org/10.1021/op4000219
Autor:
Wu-Yan Zhang, Philip C. Hogan, Chi-Li Chen, John Niu, Zhimin Wang, Danny Lafrance, Olga Gilicky, Nicholas Dunwoody, Magnus Ronn
Publikováno v:
Organic Process Research & Development; Nov2015, Vol. 19 Issue 11, p1784-1795, 12p