Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Olga G, Troyanskaya"'
Autor:
Weiguang Mao, Clare M Miller, Venugopalan D Nair, Yongchao Ge, Mary Anne S Amper, Antonio Cappuccio, Mary‐Catherine George, Carl W Goforth, Kristy Guevara, Nada Marjanovic, German Nudelman, Hanna Pincas, Irene Ramos, Rachel S G Sealfon, Alessandra Soares‐Schanoski, Sindhu Vangeti, Mital Vasoya, Dawn L Weir, Elena Zaslavsky, Biobank Team, Vanessa Barcessat, Kevin Tuballes, Diane Marie Del Valle, Kai Nie, Hui Xie, Grace Chung, Manishkumar Patel, Jocelyn Harris, Kimberly Argueta, Jacques Fehr, Barr Gruberg, Nicholas Zaki, Seunghee Kim‐Schulze, Sacha Gnjatic, Miriam Merad, Andrew G Letizia, Olga G Troyanskaya, Stuart C Sealfon, Maria Chikina
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 5, Pp 1-16 (2023)
Abstract DNA methylation comprises a cumulative record of lifetime exposures superimposed on genetically determined markers. Little is known about methylation dynamics in humans following an acute perturbation, such as infection. We characterized the
Externí odkaz:
https://doaj.org/article/4218baf29182454bb07788f37ce0f8e4
Autor:
Zijun Zhang, Natalie Sauerwald, Antonio Cappuccio, Irene Ramos, Venugopalan D. Nair, German Nudelman, Elena Zaslavsky, Yongchao Ge, Angelo Gaitas, Hui Ren, Joel Brockman, Jennifer Geis, Naveen Ramalingam, David King, Micah T. McClain, Christopher W. Woods, Ricardo Henao, Thomas W. Burke, Ephraim L. Tsalik, Carl W. Goforth, Rhonda A. Lizewski, Stephen E. Lizewski, Dawn L. Weir, Andrew G. Letizia, Stuart C. Sealfon, Olga G. Troyanskaya
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 2, Pp 100395- (2023)
Summary: Assays detecting blood transcriptome changes are studied for infectious disease diagnosis. Blood-based RNA alternative splicing (AS) events, which have not been well characterized in pathogen infection, have potential normalization and assay
Externí odkaz:
https://doaj.org/article/5c484ca215b547e3a99a03adad072323
Autor:
Frederique Ruf-Zamojski, Zidong Zhang, Michel Zamojski, Gregory R. Smith, Natalia Mendelev, Hanqing Liu, German Nudelman, Mika Moriwaki, Hanna Pincas, Rosa Gomez Castanon, Venugopalan D. Nair, Nitish Seenarine, Mary Anne S. Amper, Xiang Zhou, Luisina Ongaro, Chirine Toufaily, Gauthier Schang, Joseph R. Nery, Anna Bartlett, Andrew Aldridge, Nimisha Jain, Gwen V. Childs, Olga G. Troyanskaya, Joseph R. Ecker, Judith L. Turgeon, Corrine K. Welt, Daniel J. Bernard, Stuart C. Sealfon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mo
Externí odkaz:
https://doaj.org/article/c782850ef40d4c03ac0d69ac797d06d6
Autor:
Alessandra Soares-Schanoski, Natalie Sauerwald, Carl W. Goforth, Sivakumar Periasamy, Dawn L. Weir, Stephen Lizewski, Rhonda Lizewski, Yongchao Ge, Natalia A. Kuzmina, Venugopalan D. Nair, Sindhu Vangeti, Nada Marjanovic, Antonio Cappuccio, Wan Sze Cheng, Sagie Mofsowitz, Clare M. Miller, Xuechen B. Yu, Mary-Catherine George, Elena Zaslavsky, Alexander Bukreyev, Olga G. Troyanskaya, Stuart C. Sealfon, Andrew G. Letizia, Irene Ramos
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Young adults infected with SARS-CoV-2 are frequently asymptomatic or develop only mild disease. Because capturing representative mild and asymptomatic cases require active surveillance, they are less characterized than moderate or severe cases of COV
Externí odkaz:
https://doaj.org/article/707fabbf40d848cca1029db10b1e25b6
Autor:
Zidong Zhang, Michel Zamojski, Gregory R. Smith, Thea L. Willis, Val Yianni, Natalia Mendelev, Hanna Pincas, Nitish Seenarine, Mary Anne S. Amper, Mital Vasoya, Wan Sze Cheng, Elena Zaslavsky, Venugopalan D. Nair, Judith L. Turgeon, Daniel J. Bernard, Olga G. Troyanskaya, Cynthia L. Andoniadou, Stuart C. Sealfon, Frederique Ruf-Zamojski
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110467- (2022)
Summary: Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and ATAC-seq resource from pediatric, adult, and aged postmortem pituita
Externí odkaz:
https://doaj.org/article/9778f6fbae6c4b3ebc1fa18a2a9f30e3
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Hernandez Moura Silva, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247680 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0237773.].
Externí odkaz:
https://doaj.org/article/21d1f6bb95a349debe03d947808fbc31
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in differ
Externí odkaz:
https://doaj.org/article/d4ab345b9e074e9b86f224c51554c19b
Autor:
Rhonda A. Lizewski, Rachel S. G. Sealfon, Sang Woo Park, Gregory R. Smith, Chad K. Porter, Ana S. Gonzalez-Reiche, Yongchao Ge, Clare M. Miller, Carl W. Goforth, Hanna Pincas, Michael S. Termini, Irene Ramos, Venugopalan D. Nair, Stephen E. Lizewski, Hala Alshammary, Regina Z. Cer, Hua Wei Chen, Mary-Catherine George, Catherine E. Arnold, Lindsay A. Glang, Kyle A. Long, Francisco Malagon, Jan J. Marayag, Edgar Nunez, Gregory K. Rice, Ernesto Santa Ana, Megan A. Schilling, Darci R. Smith, Victor A. Sugiharto, Peifang Sun, Adriana van de Guchte, Zenab Khan, Jayeeta Dutta, Sindhu Vangeti, Logan J. Voegtly, Dawn L. Weir, C. Jessica E. Metcalf, Olga G. Troyanskaya, Kimberly A. Bishop-Lilly, Bryan T. Grenfell, Harm van Bakel, Andrew G. Letizia, Stuart C. Sealfon
Publikováno v:
Epidemiology. 33:797-807
Marine recruits training at Parris Island experienced an unexpectedly high rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, despite preventive measures including a supervised, 2-week, pre-entry quarantine. We characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a55105dccfe8711750749d91362db7
https://doi.org/10.1097/ede.0000000000001523
https://doi.org/10.1097/ede.0000000000001523
Autor:
Jian Zhou, Ignacio E Schor, Victoria Yao, Chandra L Theesfeld, Raquel Marco-Ferreres, Alicja Tadych, Eileen E M Furlong, Olga G Troyanskaya
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008382 (2019)
Comprehensive information on the timing and location of gene expression is fundamental to our understanding of embryonic development and tissue formation. While high-throughput in situ hybridization projects provide invaluable information about devel
Externí odkaz:
https://doaj.org/article/4bfb674b4e21452da6b50074f35ca400
Autor:
Patrick H. Bradley, Patrick A. Gibney, David Botstein, Olga G. Troyanskaya, Joshua D. Rabinowitz
Publikováno v:
mSystems, Vol 4, Iss 1 (2019)
ABSTRACT Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time, suggesting that they contribute to fitness. We developed an unsuper
Externí odkaz:
https://doaj.org/article/09b4afff416e40a2aafd564d6de98d0a