A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

Autor: Lucía Zhu, Diana Retana, Pedro García‐Gómez, Laura Álvaro‐Espinosa, Neibla Priego, Mariam Masmudi‐Martín, Natalia Yebra, Lauritz Miarka, Elena Hernández‐Encinas, Carmen Blanco‐Aparicio, Sonia Martínez, Cecilia Sobrino, Nuria Ajenjo, Maria‐Jesus Artiga, Eva Ortega‐Paino, Raúl Torres‐Ruiz, Sandra Rodríguez‐Perales, RENACER, Riccardo Soffietti, Luca Bertero, Paola Cassoni, Tobias Weiss, Javier Muñoz, Juan Manuel Sepúlveda, Pedro González‐León, Luis Jiménez‐Roldán, Luis Miguel Moreno, Olga Esteban, Ángel Pérez‐Núñez, Aurelio Hernández‐Laín, Oscar Toldos, Yolanda Ruano, Lucía Alcázar, Guillermo Blasco, José Fernández‐Alén, Eduardo Caleiras, Miguel Lafarga, Diego Megías, Osvaldo Graña‐Castro, Carolina Nör, Michael D Taylor, Leonie S Young, Damir Varešlija, Nicola Cosgrove, Fergus J Couch, Lorena Cussó, Manuel Desco, Silvana Mouron, Miguel Quintela‐Fandino, Michael Weller, Joaquín Pastor, Manuel Valiente, Adolfo de la Lama‐Zaragoza, Lourdes Calero‐Felix, Concepcion Fiaño‐Valverde, Pedro David Delgado‐López, Antonio Montalvo‐Afonso, Mar Pascual‐Llorente, Ángela Díaz‐Piqueras, SH Nam‐Cha, Cristina Barrena López, Gerard Plans Ahicart, Elena Martínez‐Saez, Santiago Ramón y Cajal, Pilar Nicolás

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-29 (2022)

Abstract We report a medium‐throughput drug‐screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metast

Externí odkaz: https://doaj.org/article/192ccb44b2e3449a849f6353de0e50dd

Patients awaiting surgery for neurosurgical diseases during the first wave of the COVID-19 pandemic in Spain: a multicentre cohort study

Autor: Pedro A Gomez, Alfonso Lagares, Ana M Castaño-León, Angel Pérez-Nuñez, Igor Paredes, Pedro González-Leon, Juan Delgado-Fernandez, Daniel García-Pérez, Olga Esteban-Sinovas, Javier Martín-Alonso, Ariel Kaen, Jorge Tirado-Caballero, Ricardo Gil-Simoes, Cristina V Torres, Natalia Frade-Porto, Patricia González-Tarno, Adrian Martin Segura, Miguel Gelabert-Gonzalez, Rebeca Pérez-Alfayate, Carlos Cotúa, Adolfo de la Lama, Fernando Ruiz-Juretschke, Vicente Casitas Hernando, Juan Casado Pellejero, David Fustero De Miguel, Jesus Moles Herbera, Jesús Goncalves-Estella, Laura Ruiz Martín, Daniel Arandia Guzmán, Andoni García Martín, Luis Torres Carretero, Marta Calvo, Pablo Miranda-Lloret, Amparo Roca Barber, Clara Paternain Martin, Marina Fidalgo De la Rosa, Luis Jiménez-Roldán, Carla Eiriz Fernández, Luis M Moreno-Gómez, Pedro D Delgado-López, Marta Ordóñez-Carmona, Francisco Arteaga-Romero, Marta González-Pombo, José F Alén, Marta Navas-García, Guillermo Blasco García de Andoain, Beatriz Menéndez-Cortezón, Brais Rodríguez-Botana, Carla Fernández-García, Borja Ferrández-Pujante, Andres C Vargas-Jiménez, Lourdes Calero Félix, Roberto García-Leal, Marc Valera-Melé, Belén Rivero, Javier Orduna-Martínez, Jorge Díaz Molina, Maria J Castelló-Ruiz, Mario Gomar-Alba, Fernando García-Pérez, Borja J Hernández-García, Jorge J Villaseñor-Ledezma, Álvaro Otero-Rodríguez, Juan J Ailagas de las Heras, Pablo Sousa-Casasnovas, Daniel Pascual-Argente, Juan C Roa Montes de Oca, Alejandra Garrido Ruiz, Miguel Rodríguez-Cadarso, Joan Antón, Arnold Quiroz-Tejada, Guillermo Carbayo-Lozano, Garazi Bermúdez, Pablo De la Fuente Villa, Íñigo L Sistiaga-Gracia, Gorka Zabalo

Publikováno v: BMJ Open, Vol 12, Iss 8 (2022)

Objectives The large number of infected patients requiring mechanical ventilation has led to the postponement of scheduled neurosurgical procedures during the first wave of the COVID-19 pandemic. The aims of this study were to investigate the factors

Externí odkaz: https://doaj.org/article/bd37abd0a42142168f6bb1980b75e28e

Novel CT-based parameters assessing relative cross-sectional area to guide surgical management and predict clinical outcomes in patients with acute subdural hematoma

Autor: Daniel García-Pérez, Ana M. Castaño-León, Luis Miguel Moreno-Gómez, Olga Esteban-Sinovas, Guillermo García-Posadas, Irene Panero-Pérez, Igor Paredes, Pedro A. Gómez-López, Alfonso Lagares

Publikováno v: Neuroradiology. 65:489-501

Acute subdural hematoma (aSDH) is one of the most devastating entities secondary to traumatic brain injury (TBI). Even though radiological computed tomography (CT) findings, such as hematoma thickness (HT), midline shift (MLS), and MLS/HT ratio, have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cf7a14030158b0b711c59f7189ffe4
https://doi.org/10.1007/s00234-022-03087-5

Intracranial Pressure Monitoring in Patients With Severe Traumatic Brain Injury: Extension of the Recommendations and the Effect on Outcome by Propensity Score Matching

Autor: Ana M. Castaño-Leon, Pedro A. Gomez, Luís Jimenez-Roldan, Igor Paredes, Pablo M. Munarriz, Irene Panero Perez, Carla Eiriz Fernandez, Daniel García-Pérez, Luis Miguel Moreno Gomez, Olga Esteban Sinovas, Guillermo Garcia Posadas, Alfonso Lagares

Publikováno v: Neurosurgery. 91(3)

Intracranial pressure (ICP) monitoring is recommended for patients with traumatic brain injury (TBI) with a Glasgow Coma Scale (GCS)9 on admission and revealing space-occupying lesions or swelling on computed tomography. However, previous studies tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28486e8053e56ebae1019592c6bcd55f
https://pubmed.ncbi.nlm.nih.gov/35876668

Patients awaiting surgery for neurosurgical diseases during the first wave of the COVID-19 pandemic in Spain: a multicentre cohort study

Autor: Ana M Castaño-Leon, Igor Paredes, Alfonso Lagares, Pedro A Gomez, Pedro González-Leon, Angel Perez-Nuñez, Luis Jiménez-Roldán, Juan Delgado-Fernández, Carla Eiriz Fernández, Daniel García-Pérez, Luis M Moreno-Gómez, Olga Esteban-Sinovas, Pedro D Delgado-López, Javier Martín-Alonso, Ariel Kaen, Jorge Tirado-Caballero, Marta Ordóñez-Carmona, Francisco Arteaga-Romero, Marta González-Pombo, José F Alén, Ricardo Gil-Simoes, Cristina V Torres, Marta Navas-García, Guillermo Blasco García de Andoain, Natalia Frade-Porto, Patricia González-Tarno, Adrian Martin Segura, Miguel Gelabert-González, Beatriz Menéndez-Cortezón, Brais Rodríguez-Botana, Rebeca Pérez-Alfayate, Carla Fernández-García, Borja Ferrández-Pujante, Andres C Vargas-Jiménez, Carlos Cotúa, Adolfo de la Lama, Lourdes Calero Félix, Fernando Ruiz-Juretschke, Roberto García-Leal, Marc Valera-Melé, Vicente Casitas Hernando, Belén Rivero, Javier Orduna-Martínez, Juan Casado Pellejero, David Fustero De Miguel, Jorge Díaz Molina, Jesús Moles Herbera, Maria J Castelló-Ruiz, Mario Gomar-Alba, Fernando García-Pérez, Borja J Hernández-García, Jorge J Villaseñor-Ledezma, Álvaro Otero-Rodríguez, Juan J Ailagas de las Heras, Jesus Gonçalves-Estella, Pablo Sousa-Casasnovas, Daniel Pascual-Argente, Laura Ruiz Martín, Juan C Roa Montes de Oca, Daniel Arandia Guzmán, Andoni García Martín, Luis Torres Carretero, Alejandra Garrido Ruiz, Marta Calvo, Pablo Miranda-Lloret, Miguel Rodríguez-Cadarso, Joan Antón, Amparo Roca Barber, Arnold Quiroz-Tejada, Guillermo Carbayo-Lozano, Garazi Bermúdez, Clara Paternain Martin, Pablo De la Fuente Villa, Marina Fidalgo De la Rosa, Íñigo L Sistiaga-Gracia, Gorka Zabalo

Publikováno v: BMJ Open
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

ObjectivesThe large number of infected patients requiring mechanical ventilation has led to the postponement of scheduled neurosurgical procedures during the first wave of the COVID-19 pandemic. The aims of this study were to investigate the factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c7c3692b31bf64a1ef65329ad31e86
https://doi.org/10.1136/bmjopen-2022-061208