Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Olga D, Lopina"'
Autor:
Sergei N. Orlov, Artem M. Tverskoi, Svetlana V. Sidorenko, Larisa V. Smolyaninova, Olga D. Lopina, Nickolai O. Dulin, Elizaveta A. Klimanova
Publikováno v:
Genes and Diseases, Vol 8, Iss 3, Pp 259-271 (2021)
With an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less than 1 nM. During the last 3 decades, the implication of these endogenous
Externí odkaz:
https://doaj.org/article/06ca50ef462249b5824f467527df1996
Autor:
Artem M. Tverskoi, Yuri M. Poluektov, Elizaveta A. Klimanova, Vladimir A. Mitkevich, Alexander A. Makarov, Sergei N. Orlov, Irina Yu. Petrushanko, Olga D. Lopina
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13268 (2021)
Cardiotonic steroids (CTSs) are specific inhibitors of Na,K-ATPase (NKA). They induce diverse physiological effects and were investigated as potential drugs in heart diseases, hypertension, neuroinflammation, antiviral and cancer therapy. Here, we co
Externí odkaz:
https://doaj.org/article/0d43722bfab145909cf5d9a1e94c8612
Autor:
Elizaveta A. Klimanova, Svetlana V. Sidorenko, Polina A. Abramicheva, Artem M. Tverskoi, Sergei N. Orlov, Olga D. Lopina
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7992 (2020)
Stimulus-dependent elevation of intracellular Ca2+ affects gene expression via well-documented calmodulin-mediated signaling pathways. Recently, we found that the addition of extra- and intracellular Ca2+ chelators increased, rather than decreased, t
Externí odkaz:
https://doaj.org/article/0bc8e6e2c2094d6198f6dbea2f547bab
Autor:
Evgeny P. Barykin, Irina Y. Petrushanko, Sergey A. Kozin, Georgy B. Telegin, Alexander S. Chernov, Olga D. Lopina, Sergey P. Radko, Vladimir A. Mitkevich, Alexander A. Makarov
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The triggers of late-onset sporadic Alzheimer’s disease (AD) are still poorly understood. Impairment of protein phosphorylation with age is well-known; however, the role of the phosphorylation in β-amyloid peptide (Aβ) is not studied sufficiently
Externí odkaz:
https://doaj.org/article/9d05c2f30fda491cb02821a30efaacfd
Autor:
Olga D. Lopina, Dmitrii A. Fedorov, Svetlana V. Sidorenko, Olesya V. Bukach, Elizaveta A. Klimanova
Publikováno v:
Biochemistry. Biokhimiia. 87(8)
The maintenance of an uneven distribution of Na+ and K+ ions between the cytoplasm and extracellular medium is the basis for the functioning of any animal cell. Changes in the intracellular ratio of these cations occur in response to numerous stimuli
Autor:
Svetlana V. Sidorenko, E. A. Klimanova, Nickolai O. Dulin, Sergei N. Orlov, Artem M. Tverskoi, Olga D. Lopina, Larisa V. Smolyaninova
Publikováno v:
Genes & Diseases
Genes and Diseases, Vol 8, Iss 3, Pp 259-271 (2021)
Genes and Diseases, Vol 8, Iss 3, Pp 259-271 (2021)
With an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less than 1 nM. During the last 3 decades, the implication of these endogenous
Autor:
Dmitry A. Fedorov, Svetlana V. Sidorenko, Alexander I. Yusipovich, Olesya V. Bukach, Andrey M. Gorbunov, Olga D. Lopina, Elizaveta A. Klimanova
Publikováno v:
Biochemistry. Biokhimiia. 87(6)
Hyperosmotic stimulation of endothelial cells often leads to its dysfunction accompanied, among other things, by proinflammatory response. The mechanisms of this phenomenon are not fully understood. It may arise due to increase in the plasma Na+ conc
Autor:
P A Abramicheva, Svetlana V. Sidorenko, Sergei N. Orlov, E. A. Klimanova, Olga D. Lopina, D A Fedorov
Publikováno v:
Biochemistry (Moscow). 85:507-515
Long-term study on the identification of Na,K-ATPase endogenous inhibitors in mammalian tissues has resulted in the discovery of ouabain, marinobufagenin (MBG), and other cardiotonic steroids (CTS) in the blood plasma. Production of ouabain and MBG i
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 14:54-60
The affinity of rodent Na+,K+-ATPase α1-subunit to cardiotonic steroids (CTS) is known to be approximately 1000-fold less than the affinity of Na+,K+-ATPase α1-subunit from other mammals. The CTS-resistant isoform of Na+,K+-ATPase α1-subunit (α1R
Autor:
Yuri M. Poluektov, Irina Yu. Petrushanko, Olga D. Lopina, E. A. Dergousova, Alexander A. Makarov, Vladimir A. Mitkevich
Publikováno v:
Biochemical and Biophysical Research Communications. 510:86-90
The functioning of the N, K-ATPase depends on the redox status of cells and its activity is inhibited by oxidative stress and hypoxia. We previously found that redox sensitivity of the Na,K-ATPase is mediated by glutathionylation of the α-subunit. A