Výsledky vyhledávání - "Olga Caamaño"

Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists

Autor: José Brea, Jhonny Azuaje, Hugo Gutiérrez-de-Terán, Olga Caamaño, Carmen Velando, María Isabel Loza, Xerardo García-Mera, Ana Mallo-Abreu, María Majellaro, Willem Jespers, Rubén Prieto-Díaz, Eddy Sotelo

Publikováno v: Journal of Medicinal Chemistry. 63:7721-7739

A systematic exploration of bioisosteric replacements for furan and thiophene cores in a series of potent A2BAR antagonists has been carried out using the nitrogen-walk approach. A collection of 42 novel alkyl 4-substituted-2-methyl-1,4-dihydrobenzo[

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffeb629a9b8edde0c6e407cce9e5e51f
https://doi.org/10.1021/acs.jmedchem.0c00564

Zobrazit plný text záznamu

Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition

Autor: Xerardo García-Mera, Jhonny Azuaje, Willem Jespers, Olga Caamaño, Hugo Gutiérrez-de-Terán, María Isabel Loza, María Majellaro, Eddy Sotelo, José Brea, Ana Mallo-Abreu

Publikováno v: Journal of Medicinal Chemistry. 62:9315-9330

We report the identification of two subsets of fluorinated nonxanthine A2B adenosine receptor antagonists. The novel derivatives explore the effect of fluorination at different positions of two pyrimidine-based scaffolds. The most interesting ligands

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89b2474a26355933cbaa750412c12bb4
https://doi.org/10.1021/acs.jmedchem.9b01340

Zobrazit plný text záznamu

One-pot Preparation and Characterisation of Five-membered Cyclic Alcohols

Autor: Marcos Garcia, Olga Caamaño, Joana Ferreira da Costa, Xerardo García-Mera

Publikováno v: Letters in Organic Chemistry. 15:546-550

Background: Over the last few years, one of the primary focuses of our research group has been the synthesis and biological evaluation CANs featuring structural and/or configurationally alterations on the carbocyclic moiety. We previously reported an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77caabfa68bcd2a2202e5b1a34fb96a8
https://doi.org/10.2174/1570178614666170710103442

Zobrazit plný text záznamu

(±)-3,5-Bis(substitutedmethyl)pyrrolidines: Application to the Synthesis of Analogues of glycine-L-proline-L-glutamic Acid (GPE)

Autor: J. Q. Ferreira, Olga Caamaño, David Silva, Xerardo García-Mera

Publikováno v: Current Organic Synthesis. 15:230-236

Backiground: Alzheimer's disease is a fatal, complex, neurodegenerative disease over 46 million people live with dementia in the world characterized by the presence of plaques containing β-amyloid and neuronal loss. The GPE acts as a survival factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fd3b4897ed6937ff8ecdee9c62830f8
https://doi.org/10.2174/1570179414666170821115323

Zobrazit plný text záznamu

Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists

Autor: Eddy Sotelo, Johan Åqvist, Vicente Yaziji, Hugo Gutiérrez-de-Terán, Ana Mallo, María Majellaro, María Isabel Cadavid, Willem Jespers, Olga Caamaño, María Isabel Loza, José Brea, Jhonny Azuaje

Publikováno v: Journal of Medicinal Chemistry. 60:7502-7511

We report the first family of 2-acetamidopyridines as potent and selective A3 adenosine receptor (AR) antagonists. The computer-assisted design was focused on the bioisosteric replacement of the N1 atom by a CH group in a previous series of diarylpyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ee66046dc5144fdc2cde2bdb32f199a
https://doi.org/10.1021/acs.jmedchem.7b00860

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání