Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Olga Buneeva"'
Autor:
Olga Buneeva, Alexei Medvedev
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1303 (2024)
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), also known as Parkinson’s disease protein 5, is a highly expressed protein in the brain. It plays an important role in the ubiquitin–proteasome system (UPS), where it acts as a deubiquitinase (DUB
Externí odkaz:
https://doaj.org/article/ce79d6930e054131bfa0b777ae105ad2
Autor:
Alexei Medvedev, Olga Buneeva
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of th
Externí odkaz:
https://doaj.org/article/2573dd60ad4d464b8121c2126370a23d
Autor:
Olga Buneeva, Arthur Kopylov, Oksana Gnedenko, Marina Medvedeva, Alexander Veselovsky, Alexis Ivanov, Victor Zgoda, Alexei Medvedev
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7634 (2023)
Affinity-based proteomic profiling is widely used for the identification of proteins involved in the formation of various interactomes. Since protein–protein interactions (PPIs) reflect the role of particular proteins in the cell, identification of
Externí odkaz:
https://doaj.org/article/8c89fb40b396425f917593a71641902c
Publikováno v:
Data in Brief, Vol 38, Iss , Pp 107276- (2021)
Fractions of 26S and 20S proteasomes isolated from the rabbit brain by the method of salt fractionation (salt-induced precipitation) contain intrinsic proteasome proteins responsible for assembly of the core particle and regulatory particle of protea
Externí odkaz:
https://doaj.org/article/caf8c71a07a241bba1b6a2628cce34ee
Autor:
Marina Solovieva, Yuri Shatalin, Irina Odinokova, Olga Krestinina, Yulia Baburina, Yana Lomovskaya, Anton Pankratov, Natalia Pankratova, Olga Buneeva, Arthur Kopylov, Alexei Medvedev, Vladimir Akatov
Publikováno v:
Membranes, Vol 12, Iss 9, p 845 (2022)
Disulfiram (DSF) and its derivatives were here investigated as antineoplastic agents, and their important feature is the ability to influence the UPS. We have recently shown that hydroxocobalamin catalyzes the aerobic oxidation of diethyldithiocarbam
Externí odkaz:
https://doaj.org/article/9ee1b52052b143af92f3503c44d85a7d
Autor:
Olga Buneeva, Alexei Medvedev
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3705 (2022)
Ubiquitination (the covalent attachment of ubiquitin molecules to target proteins) is one of the main post-translational modifications of proteins. Historically, the type of polyubiquitination, which involves K48 lysine residues of the monomeric ubiq
Externí odkaz:
https://doaj.org/article/e0a62ec5734e4373881dde077f42a7cb
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 591 (2020)
Mitochondria, the energy stations of the cell, are the only extranuclear organelles, containing their own (mitochondrial) DNA (mtDNA) and the protein synthesizing machinery. The location of mtDNA in close proximity to the oxidative phosphorylation sy
Externí odkaz:
https://doaj.org/article/a0eddd1c69424fe7816c04093e6e705f
Autor:
Valerii Fedchenko, Arthur Kopylov, Nadezhda Kozlova, Olga Buneeva, Alexei Kaloshin, Victor Zgoda, Alexei Medvedev
Publikováno v:
Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 593-603 (2016)
Background/Aims: Renalase is a recently discovered flavoprotein involved in regulation of blood pressure. Altered renalase levels have been found in blood of patients with end stage renal disease. The antihypertensive effect of circulating renalase i
Externí odkaz:
https://doaj.org/article/dc35edf7b0be454e9855a808d1afb7df
Autor:
Alexei Medvedev, Arthur Kopylov, Olga Buneeva, Leonid Kurbatov, Olga Tikhonova, Alexis Ivanov, Victor Zgoda
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4187 (2020)
Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting a wide range of biological and pharmacological activities. At doses of 100 mg/kg and above, isatin is neuroprotective in different experimental models of neurodegeneration. Good evidenc
Externí odkaz:
https://doaj.org/article/27189628fd6944bf8e985bf8a366ce2d
Publikováno v:
Cells, Vol 7, Iss 8, p 91 (2018)
Mitochondria are a crucial target for the actions of neurotoxins, causing symptoms of Parkinson’s disease in various experimental animal models, and also neuroprotectors. There is evidence that mitochondrial dysfunction induced by the neurotoxin 1-
Externí odkaz:
https://doaj.org/article/8283ddb8850c4a72b859ee51afdd9f90